Antibody News and Research

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An antibody is a blood protein that is produced in response to and counteracts an antigen. Antibodies are produced in response to disease and help the body fight against the particular disease. In this way, antibodies help the body develop an immunity to disease.

Broad neutralization of SARS-CoV-2 spike protein by an unconventional antibody fragment

A new preprint research paper posted to the bioRxiv* server examines the nature and effects of the spike mutations and identifies a vulnerable point that could help develop broad-spectrum protection against circulating variants.

21 Dec 2021

Early administration of SARS-CoV-2 convalescent plasma reduces outpatient hospitalizations

The results of a nationwide, multicenter clinical trial led by Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health provides solid evidence for the use of plasma from convalescent patients — those who have recovered from the disease and whose blood contains antibodies against SARS-CoV-2, the virus that causes COVID-19 — as an early treatment.

21 Dec 2021

Comparison of point-of-care SARS-CoV-2 diagnostic kits

A multinational group of scientists investigates the performance characteristics of several point-of-care diagnostic kits for SARS-CoV-2.

21 Dec 2021

What are the long-term effects of COVID-19 on mental health?

Researchers determine the long-term adverse mental health symptoms associated with COVID-19 by estimating acute infection severity.

21 Dec 2021

Molecular mechanism of SARS-Cov-2-induced thrombosis

Researchers demonstrate that the exposure of platelets to the SARS-CoV-2 spike protein promotes their activation and adhesion.

21 Dec 2021

Booster doses offer broader protection in SARS-CoV-2 infected and vaccinated individuals

Researchers determined IgG titers of vaccinated healthcare workers 11 months following primary COVID-19 vaccination.

21 Dec 2021

Severe COVID-19 found to be associated with disrupted intestinal Peyer’s patches

A new study demonstrates significantly altered structure and cellularity of Peyer’s patches in deceased COVID-19 patients.

21 Dec 2021

Effect of T cell reactivity in COVID-19 infection and vaccination

Researchers recently developed an immunodiagnostic T cell assay to classify T cell immune responses of the subjects based on their coronavirus disease 2019 infection and vaccination history.

21 Dec 2021

Identifying a recurring pattern in broadly neutralizing antibodies that can target an epitope on SARS-CoV-2

Interesting research decrypts a recurring sequence in antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) and identifies it to be a board neutralizing antibody that targets a conserved epitope on the SARS-CoV-2 receptor-binding domain (RBD) of the spike protein.

21 Dec 2021

$Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma$

Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma

Early results from an Alliance for Clinical Trials in Oncology randomized clinical trial of adults with multiple myeloma relapsing on frontline lenalidomide therapy showed that adding ixazomib (Ninlaro®) to pomalidomide and dexamethasone as part of second line therapy extended the length of time patients lived before their disease worsened (progression-free survival) compared with patients who received pomalidomide and dexamethasone.

21 Dec 2021

Study focuses on inherited Alzheimer’s up to 25 years before expected dementia onset

Washington University School of Medicine in St. Louis is launching an international clinical trial aimed at preventing Alzheimer's disease in people genetically destined to develop the illness at a young age. Unlike most other Alzheimer's prevention trials, this one will enroll people before the disease has taken hold - up to 25 years before the expected onset of dementia.

21 Dec 2021

Booster shots improve CD8+ T cell response to SARS-CoV-2 in animal model

In a new study, published on the bioRxiv* preprint server, scientists showed in a mice model that three doses of the same synthetic peptide vaccine, eliciting an exclusive CD8+ T cell response against one SARS-CoV-2 Spike epitope, protected against lethal SARS-CoV-2 infection, in the absence of neutralizing antibodies. Researchers also showed that the third dose resulted in superior generation of effector-memory T cells in the circulation and tissue-resident memory T (TRM) cells.

20 Dec 2021

An Omicron wave predicted for England from December 2021 to April 2022

A study, published on the medRxiv* preprint server, focuses on the interaction between Omicron variants and public health interventions in England that promote immunity.

20 Dec 2021

New study suggests most monoclonal antibody treatments are ineffective against Omicron SARS-CoV-2 variant

The arrival of the Omicron (B.1.1.529) variant has brought into question the effectiveness of current COVID-19 treatments in preventing infection and death. New research published in the preprint bioRxiv* server suggests the efficacy of most monoclonal antibody treatments are ineffective against Omicron.

20 Dec 2021

Scientists develop first photo-electrochemical aptasensor to detect SARS-CoV-2 virus in saliva

Scientists at the Universidad Carlos III de Madrid (UC3M) have developed the first photo-electrochemical aptasensor that detects the SARS-CoV-2 virus in a saliva sample.

20 Dec 2021

New Omicron variant may be better at evading vaccine-induced antibodies, research shows

The Omicron variant of SARS-CoV-2 may be significantly better than previous variants at evading vaccine-induced antibodies, according to new research from Cambridge - but preliminary evidence suggests it is less likely to cause severe COVID-19 illness in the lungs.

20 Dec 2021

Antibody News and Research

Further Reading

Broad neutralization of SARS-CoV-2 spike protein by an unconventional antibody fragment

Early administration of SARS-CoV-2 convalescent plasma reduces outpatient hospitalizations

Comparison of point-of-care SARS-CoV-2 diagnostic kits

What are the long-term effects of COVID-19 on mental health?

Molecular mechanism of SARS-Cov-2-induced thrombosis

Booster doses offer broader protection in SARS-CoV-2 infected and vaccinated individuals

Severe COVID-19 found to be associated with disrupted intestinal Peyer’s patches

Effect of T cell reactivity in COVID-19 infection and vaccination

Identifying a recurring pattern in broadly neutralizing antibodies that can target an epitope on SARS-CoV-2

Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma

Study focuses on inherited Alzheimer’s up to 25 years before expected dementia onset

Booster shots improve CD8+ T cell response to SARS-CoV-2 in animal model

An Omicron wave predicted for England from December 2021 to April 2022

New study suggests most monoclonal antibody treatments are ineffective against Omicron SARS-CoV-2 variant

Scientists develop first photo-electrochemical aptasensor to detect SARS-CoV-2 virus in saliva

New Omicron variant may be better at evading vaccine-induced antibodies, research shows

Omicron variant of SARS-CoV-2 exhibits striking antibody evasion

Reduced antibody-mediated neutralization by the SARS-CoV-2 Omicron variant

Computational analysis of the effect of SARS-CoV-2 Omicron variant spike protein mutations

A test to identify antibody effectiveness against COVID-19 variants

Using single B cell screening to boost antibody discovery eBook

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