Clinical Trial News and Research

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Researchers receive PCORI funding to study the effectiveness of individualized model of hemodialysis

The Patient-Centered Outcomes Research Institute (PCORI) recently awarded researchers at Wake Forest University School of Medicine $10.2 million to study the effectiveness of an individualized model of hemodialysis, a procedure in which the blood is cleaned by a dialysis machine.

9 Mar 2023

Nirogacestat shows promising results in patients with desmoid tumors

When Dana Avellino, now 36, first noticed a lump near her groin in the summer of 2018, she thought it was related her recent cesarean section. Her younger daughter was only 2 months old at the time.

9 Mar 2023

Researchers develop a 100%-effective mRNA vaccine for deadly bacteria

For the first time in the world: a team of researchers from Tel Aviv University and the Israel Institute for Biological Research have developed an mRNA-based vaccine that is 100% effective against a type of bacteria that is lethal to humans.

9 Mar 2023

Early outpatient treatment of COVID-19 with metformin could reduce the risk of developing long COVID

In a recent study posted to Preprints with The Lancet*, a team of researchers from the United States investigated whether early outpatient treatment of coronavirus disease 2019 (COVID-19) patients with fluvoxamine, ivermectin, or metformin could prevent long coronavirus disease (long COVID).

9 Mar 2023

Ingestion of waterborne nitrate could be a risk factor for prostate cancer

The nitrate ingested over the course of a person's adult lifetime through the consumption of tap water and bottled water could be a risk factor for prostate cancer, particularly in the case of aggressive tumors and in younger men.

9 Mar 2023

Study suggests a new approach for treating metastatic breast cancers

Metastatic breast cancer has no cure and has proven stubbornly resistant to one of the most innovative and promising new cancer treatments: immunotherapy.

8 Mar 2023

Investigating treat-to-target low-density lipoprotein-cholesterol versus high-intensity statins for coronary artery disease

In a recent study published in JAMA, researchers investigated whether treat-to-target (TTT) low-density lipoprotein-cholesterol (LDL-C) therapy was inferior to administering statins of high intensity for clinical outcomes in the long term among coronary artery disease (CAD) patients.

8 Mar 2023

Study identifies a potential new treatment approach for acute myeloid leukemia

A team of researchers has discovered a potential therapeutic that can synergize with existing drugs to more effectively kill certain leukemia cells.

8 Mar 2023

Breakthrough drug works against all the main types of primary bone cancer

Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer.

8 Mar 2023

Typically developing infants perceive audio-video synchrony better than children at risk for autism

Rutgers research that may eventually enable far earlier autism diagnoses shows that typically developing infants perceive audio-video synchrony better than high-risk for autism infants.

7 Mar 2023

Virtual care team strategy found to be safe and effective in improving treatment for heart failure patients

Recent studies have provided strong evidence that patients with heart failure can benefit from medical therapies that can reduce risk of worsening symptoms and extend patients' lives.

7 Mar 2023

Denosumab may benefit postmenopausal patients with hormone receptor-negative breast tumors and RANK protein expression

The drug denosumab is currently used to treat osteoporosis and bone metastases. For more than a decade, its potential therapeutic benefit in the treatment of breast cancer has also been studied.

7 Mar 2023

The safety of short-course compared to long-course antibiotic therapy for ventilator-associated pneumonia

Researchers performed a meta-analysis of randomized controlled trials to evaluate the safety of short-course antibiotic treatment versus long-course antibiotic treatment for ventilator-associated pneumonia.

7 Mar 2023

Study: Women have higher risk of dying after coronary artery bypass surgery than men

Compared with men, women continue to have a roughly 30-40 percent higher risk of dying following coronary artery bypass surgery, according to a large study led by investigators at Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center.

6 Mar 2023

Physical activity and motivational support have no long-term effects on smoking cessation

Promoting physical activity and other behavioral support can help people wanting to reduce their smoking to quit in the short-term.

6 Mar 2023

Yale Cancer Center receives funding to increase access to early phase clinical trials

Yale Cancer Center is pleased to announce collaborative funding to support and increase access to early phase clinical trials for patients at community sites for cancer care in Connecticut.

6 Mar 2023

Study examines the relationship between exclusive human milk consumption and gut microbiota in preterm infants

Researchers examine the impact of an exclusive human milk diet on the infant gut microbiome.

6 Mar 2023

High-dose anticoagulation can reduce deaths, intubations in hospitalized COVID-19 patients

High-dose anticoagulation can reduce deaths by 30 percent and intubations by 25 percent in hospitalized COVID-19 patients who are not critically ill when compared to the standard treatment, which is low-dose anticoagulation.

6 Mar 2023

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

MK-0616, an experimental oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, met its primary endpoint and substantially reduced levels of low-density lipoprotein (LDL) cholesterol in people with high cholesterol and/or heart disease related to clogged arteries, in a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

A clinical trial testing a freeze-dried, temperature-stable experimental tuberculosis (TB) vaccine in healthy adults found that it was safe and stimulated both antibodies and responses from the cellular arm of the immune system.

6 Mar 2023

Clinical Trial News and Research

Researchers receive PCORI funding to study the effectiveness of individualized model of hemodialysis

Nirogacestat shows promising results in patients with desmoid tumors

Researchers develop a 100%-effective mRNA vaccine for deadly bacteria

Early outpatient treatment of COVID-19 with metformin could reduce the risk of developing long COVID

Ingestion of waterborne nitrate could be a risk factor for prostate cancer

Study suggests a new approach for treating metastatic breast cancers

Investigating treat-to-target low-density lipoprotein-cholesterol versus high-intensity statins for coronary artery disease

Study identifies a potential new treatment approach for acute myeloid leukemia

Breakthrough drug works against all the main types of primary bone cancer

Typically developing infants perceive audio-video synchrony better than children at risk for autism

Virtual care team strategy found to be safe and effective in improving treatment for heart failure patients

Denosumab may benefit postmenopausal patients with hormone receptor-negative breast tumors and RANK protein expression

The safety of short-course compared to long-course antibiotic therapy for ventilator-associated pneumonia

Study: Women have higher risk of dying after coronary artery bypass surgery than men

Physical activity and motivational support have no long-term effects on smoking cessation

Yale Cancer Center receives funding to increase access to early phase clinical trials

Study examines the relationship between exclusive human milk consumption and gut microbiota in preterm infants

High-dose anticoagulation can reduce deaths, intubations in hospitalized COVID-19 patients

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

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