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Distribution of c-Myc protein during asymmetric cell division influences fate, roles of activated T cells

The fates of immune cells can be decided at the initial division of a cell. Researchers at St. Jude Children's Research Hospital have discovered that the production of daughter cells with different roles in the immune system is driven by the lopsided distribution of the signaling protein c-Myc. Nudging c-Myc in one direction or the other could make vaccines more effective or advance immunotherapies for cancer treatment. The research appears online today in the scientific journal Nature.

12 Apr 2016

Advances in NMR metabolomics: an interview with Professor Tone F. Bathen

The main objective of our research is to improve and individualize cancer diagnostics and cancer treatment. We try to achieve this through the integrated use of MR technology and the development of data-driven tools to analyze tumors on both a functional and molecular level.

From Bruker BioSpin Group 11 Apr 2016

Study finds how tumour cells grow through scavenging bad cholesterol

Several studies have recognized a link between obesity and cancer. Richard Lehner, professor of Pediatrics and investigator at the University of Alberta's Faculty of Medicine & Dentistry, has taken his research further to understand how tumour cells grow through scavenging very low-density lipoproteins (VLDL) and low-density lipoproteins (LDL), commonly known as the "bad cholesterol", and what mechanisms can be used to reduce the malignant cells' growth.

11 Apr 2016

Simple blood test rapidly detects key genetic mutations in non-small cell lung tumors

A simple blood test can rapidly and accurately detect mutations in two key genes in non-small cell lung tumors, researchers at Dana-Farber Cancer Institute and other institutions report in a new study - demonstrating the test's potential as a clinical tool for identifying patients who can benefit from drugs targeting those mutations.

11 Apr 2016

AstraZeneca, MedImmune to present new clinical trial and scientific data on lung cancer treatments at ELCC 2016

AstraZeneca and its global biologics research and development arm, MedImmune, will report new clinical trial and scientific data from their industry-leading lung cancer franchise of marketed and pipeline medicines at the European Lung Cancer Conference in Geneva, Switzerland, 13 -16 April 2016.

11 Apr 2016

Breast cancer medication letrozole could increase ovulation in women with PCOS

A medicine used in breast cancer treatment is now considered the best option for treating the most common cause of infertility.

6 Apr 2016

U of S-led researchers develop novel class of compounds for effective cancer treatment

A novel class of compounds developed by a University of Saskatchewan-led research team could yield more effective and less toxic chemotherapy drugs to treat cancer.

2 Apr 2016

HDAC inhibitors could improve activity of immunotherapeutic antibodies in lung cancer patients

Several new immunotherapeutic antibodies that inhibit checkpoint receptors on T cells to restimulate the immune system to target tumors have been approved to treat advanced stage lung cancer and melanoma; however, only 20 percent of lung cancer patients show a response to these agents.

2 Apr 2016

Fertility 'reassurance' for most chemotherapy-treated female childhood cancer survivors

Both female and male chemotherapy-treated survivors of childhood cancer have an increased risk of impaired fertility, but results suggest that the risk in women is limited to those given specific chemotherapy drugs.

31 Mar 2016

Scientists develop triple-stage 'cluster bomb' system to deliver cisplatin drug through nanoparticles

Scientists have devised a triple-stage "cluster bomb" system for delivering the chemotherapy drug cisplatin, via tiny nanoparticles designed to break up when they reach a tumor.

30 Mar 2016

Low-oxygen conditions spur growth of breast cancer stem cells

Working with human breast cancer cells and mice, scientists at The Johns Hopkins University say new experiments explain how certain cancer stem cells thrive in low oxygen conditions. Proliferation of such cells, which tend to resist chemotherapy and help tumors spread, are considered a major roadblock to successful cancer treatment.

29 Mar 2016

Gleevec could be novel therapeutic agent for type 2 diabetes

The cancer treatment drug Imatinib, otherwise known as Gleevec is approved to treat various forms of cancer, mostly notably chronic myeloid leukemia (CML). However, researchers have stumbled onto another possible use for it, curing type 2 diabetes.

28 Mar 2016

Wnt secretion inhibitors may reduce renal fibrosis

Renal fibrosis or the scarring of kidneys, following an injury, reduces their function and can cause kidney disease to progressively worsen.

25 Mar 2016

Self-repairing cancer cells: A new pathway for cancer treatment

With narrow bodies and no collarbones, mice are able to squeeze through holes as small as a quarter-inch in diameter. Cancer cells similarly are able to migrate through extremely tight quarters but with a major difference: The journey often comes at a price - the deformation and, in some cases, rupture of the outer lining of a cell's nucleus. While deformation and rupture can sometimes lead to cell death, the cell - about 90 percent of the time - also has the ability to repair itself.

25 Mar 2016

Microneedle-embedded patch delivers cancer immunotherapy directly to melanoma

Biomedical engineering researchers at North Carolina State University and the University of North Carolina at Chapel Hill have developed a technique that uses a patch embedded with microneedles to deliver cancer immunotherapy treatment directly to the site of melanoma skin cancer. In animal studies, the technique more effectively targeted melanoma than other immunotherapy treatments.

25 Mar 2016

TSRI scientists develop new process to synthesize naturally occurring compound phorbol

In a landmark feat of chemical synthesis, scientists at The Scripps Research Institute have developed a 19-step process for making the naturally occurring compound phorbol in the laboratory, in quantities that are useful for pharmaceutical research.

24 Mar 2016

Women who have survived childhood cancer can become pregnant, shows study

For women who have survived childhood cancer, the impact of modern chemotherapy regimens on the likelihood of becoming pregnant is generally small, and most have a good chance of conceiving, according to one of the largest studies of its kind published in The Lancet Oncology.

24 Mar 2016

Mount Sinai Hospital uses M1 LUMI Bead loaded with doxorubicin for liver cancer treatment

An innovative cancer treatment made of luminescent chemotherapy-filled beads injected into tumors through the wrist is now available for patients with inoperable and difficult-to-treat liver cancer.

23 Mar 2016

Targeted therapies suppress T cell activity that could actually help fight tumors

In many cases, targeted therapies for cancer are preferred as treatments over chemotherapy and surgery because they attack and kill cancer cells with specific tumor-promoting mutations while sparing healthy, normal cells that do not express these mutations.

23 Mar 2016

Tiny gel slivers open way to personalised cancer treatment targeting particular tumour

They look like small, translucent gems but these tiny 'gel' slivers hold the world of a patient's tumour in microcosm ready for trials of anti-cancer drugs to find the best match between treatment and tumour.

22 Mar 2016

Cancer Treatment News and Research

Distribution of c-Myc protein during asymmetric cell division influences fate, roles of activated T cells

Advances in NMR metabolomics: an interview with Professor Tone F. Bathen

Study finds how tumour cells grow through scavenging bad cholesterol

Simple blood test rapidly detects key genetic mutations in non-small cell lung tumors

AstraZeneca, MedImmune to present new clinical trial and scientific data on lung cancer treatments at ELCC 2016

Breast cancer medication letrozole could increase ovulation in women with PCOS

U of S-led researchers develop novel class of compounds for effective cancer treatment

HDAC inhibitors could improve activity of immunotherapeutic antibodies in lung cancer patients

Fertility 'reassurance' for most chemotherapy-treated female childhood cancer survivors

Scientists develop triple-stage 'cluster bomb' system to deliver cisplatin drug through nanoparticles

Low-oxygen conditions spur growth of breast cancer stem cells

Gleevec could be novel therapeutic agent for type 2 diabetes

Wnt secretion inhibitors may reduce renal fibrosis

Self-repairing cancer cells: A new pathway for cancer treatment

Microneedle-embedded patch delivers cancer immunotherapy directly to melanoma

TSRI scientists develop new process to synthesize naturally occurring compound phorbol

Women who have survived childhood cancer can become pregnant, shows study

Mount Sinai Hospital uses M1 LUMI Bead loaded with doxorubicin for liver cancer treatment

Targeted therapies suppress T cell activity that could actually help fight tumors

Tiny gel slivers open way to personalised cancer treatment targeting particular tumour

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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