Clinical Trial News and Research

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Study to determine if a DNA-based blood test can help detect cancer predisposition in NF1 patients

The Children’s Tumor Foundation (CTF) has announced a groundbreaking 3-year study, which it will fund for nearly $2 million, to determine if a DNA-based blood test can offer better understanding and ultimately earlier diagnosis of cancer predisposition in neurofibromatosis type 1 (NF1) patients.

16 Dec 2022

Trial results confirm the safety of three different Ebola vaccine regimens

Ebola epidemics occur periodically in various sub-Saharan African countries. While vaccines exist and have already received WHO Prequalification against the Zaire ebolavirus species, it is essential to pursue and intensify efforts to supplement the available data to develop a safe and effective Ebola vaccine strategies in adults and children alike.

16 Dec 2022

Walnut consumption has positive effects on stressed university students

Stressed university students might want to add walnuts to their daily diet in the weeks leading up to their next exam.

16 Dec 2022

Does nirmatrelvir and ritonavir reduce the risk of hospitalization or death among outpatients with early COVID-19?

Researchers investigated the efficacy of ritonavir and nirmatrelvir combination treatment in reducing the risk of COVID-19 severity outcomes such as hospital admissions and deaths when administered during the initial period of SARS-CoV-2 infections.

16 Dec 2022

Experimental therapy shows promise as treatment for metastatic colon cancer in preclinical models

An experimental therapy showed promise as treatment for an aggressively spreading type of colorectal cancer in preclinical models, according to a new study by Weill Cornell Medicine investigators.

16 Dec 2022

Is legislation to safeguard Americans against superbugs a boondoggle or breakthrough?

With time running out in the 2022 congressional session, a bipartisan coalition of lawmakers and infectious disease specialists is scrambling to pass a bill aimed at spurring the development of antibiotics to combat the deadly spread of drug-resistant pathogens.

16 Dec 2022

Imaging method yields highly accurate and precise values of radionuclide organ uptake

Patients with cancer that has spread to the bone are sometimes treated with alpha particle radiation therapy that is delivered into or very close to the tumor.

16 Dec 2022

Walnut consumption may have a protective effect against academic stress in university students

Being a university student is an especially stressful time in life. In fact, eight in 10 university students report experiencing frequent bouts of stress and 61% of university students seek counseling for anxiety, depression or other needs.

15 Dec 2022

Incidence of Parkinson's disease among older adults is 50% higher than current estimates, study reveals

A new study reveals that the annual incidence of Parkinson's disease (PD) among older adults is 50% higher than current estimates of 60,000 diagnoses annually.

15 Dec 2022

Gut-dwelling bacteria can promote the desire to exercise, study shows

Some species of gut-dwelling bacteria activate nerves in the gut to promote the desire to exercise, according to a study in mice that was led by researchers at the Perelman School of Medicine at the University of Pennsylvania.

15 Dec 2022

Study uncovers previously unknown genetic cause of late-onset cerebellar ataxia

A new study published on Dec. 14, 2022 in the New England Journal of Medicine reports the identification of a previously unknown genetic cause of a late-onset cerebellar ataxia, a discovery that will improve diagnosis and open new treatment avenues for this progressive condition.

15 Dec 2022

No benefit of low dose apixaban following acute COVID-19

The HEAL-COVID trial compared the efficacy of Apixaban to standard care in adults who have recently recovered from severe COVID-19.

14 Dec 2022

Updated guidelines seek to improve transparency and utility in clinical trial reporting

In a global study of outcome reporting in clinical trials, a research team at The Hospital for Sick Children (SickKids) has issued updated guidelines on what should be included in all trial protocols and published clinical trial reports, with the goal to improve their transparency and utility.

14 Dec 2022

Study: Exercise, mindfulness training, or both do not improve cognitive performance in seniors

Older adults work with exercise trainers as part of a study to see whether exercise, mindfulness training, or both might improve cognitive performance in seniors.

13 Dec 2022

Study finds bebtelovimab therapy lacks efficacy in patients infected with SARS-CoV-2 Omicron subvariants

Researchers assessed the impact of bebtelovimab (BEB) monoclonal antibody in the treatment of high-risk SARS-CoV-2 Omicron variant-infected patients.

13 Dec 2022

Novel monoclonal antibody therapy shows promising results in patients with moderate to severe atopic dermatitis

Patients with moderate to severe atopic dermatitis who participated in a clinical trial of rocatinlimab - a novel, patient-tailored monoclonal antibody therapy - showed promising results both while taking the drug and up to 20 weeks after the therapy was stopped, Mount Sinai researchers reported in The Lancet.

12 Dec 2022

GOSH delivers world-first base-edited cell therapy for a patient with relapsed T cell leukemia

A patient with relapsed T cell leukemia has been given base-edited T-cells in a world-first use of a base-edited cell therapy, in a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).

12 Dec 2022

Three-drug combination highly effective in patients with high-risk forms of chronic lymphocytic leukemia

A three-drug combination that sent chronic lymphocytic leukemia (CLL) into deep remissions in a broad group of patients in a clinical trial is highly effective in patients with high-risk forms of the disease, a new, phase 2 clinical trial led by Dana-Farber Cancer Institute investigators indicates.

12 Dec 2022

Extra year of chemotherapy lowers the risk of cancer recurrence in children with Ikaros leukemia

Many children with ALL have a good outcome of their disease. After two years of chemotherapy treatment, nine out of ten children are cured. But some children have a more aggressive form of the disease.

12 Dec 2022

Aging influences the diagnosis and treatment of heart attacks in patients over age 75

For people ages 75 and older, age-related changes in general health and in the heart and blood vessels require consideration and likely modifications in how heart attacks and heart disease are treated, according to a new American Heart Association scientific statement published today in the Association's flagship, peer-reviewed journal Circulation.

12 Dec 2022

Clinical Trial News and Research

Study to determine if a DNA-based blood test can help detect cancer predisposition in NF1 patients

Trial results confirm the safety of three different Ebola vaccine regimens

Walnut consumption has positive effects on stressed university students

Does nirmatrelvir and ritonavir reduce the risk of hospitalization or death among outpatients with early COVID-19?

Experimental therapy shows promise as treatment for metastatic colon cancer in preclinical models

Is legislation to safeguard Americans against superbugs a boondoggle or breakthrough?

Imaging method yields highly accurate and precise values of radionuclide organ uptake

Walnut consumption may have a protective effect against academic stress in university students

Incidence of Parkinson's disease among older adults is 50% higher than current estimates, study reveals

Gut-dwelling bacteria can promote the desire to exercise, study shows

Study uncovers previously unknown genetic cause of late-onset cerebellar ataxia

No benefit of low dose apixaban following acute COVID-19

Updated guidelines seek to improve transparency and utility in clinical trial reporting

Study: Exercise, mindfulness training, or both do not improve cognitive performance in seniors

Study finds bebtelovimab therapy lacks efficacy in patients infected with SARS-CoV-2 Omicron subvariants

Novel monoclonal antibody therapy shows promising results in patients with moderate to severe atopic dermatitis

GOSH delivers world-first base-edited cell therapy for a patient with relapsed T cell leukemia

Three-drug combination highly effective in patients with high-risk forms of chronic lymphocytic leukemia

Extra year of chemotherapy lowers the risk of cancer recurrence in children with Ikaros leukemia

Aging influences the diagnosis and treatment of heart attacks in patients over age 75

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