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De-risking drug development free webinar from Envigo

De-risking represents a relatively new but developing strategy designed to quickly assess if a new drug has a liability. Knowing your compound’s risk for drug-to-drug interactions (DDI), drug induced liver injury (DILI) and metabolites in safety testing (MIST) early on in drug development, leads to greater confidence and added value on your molecule’s journey to market.

18 Nov 2016

Study offers new insight into why some women have difficulty in falling pregnant

Southampton researchers have found new insight into why some women have difficulty falling pregnant.

15 Nov 2016

Researchers lay foundation for improved TB treatment by targeting new enzyme

Researchers at Johns Hopkins report they have laid the foundation to develop novel antibiotics that work against incurable, antibiotic-resistant bacteria like tuberculosis by targeting an enzyme essential to the production and integrity of bacterial cell walls.

10 Nov 2016

NCATS funds collaboration initiative aimed at repurposing antimalarial to combat Ebola virus

The National Center for Advancing Translational Sciences recently awarded $596,533.00 to Collaborations Pharmaceuticals, Inc. to initiate a partnership with Texas Biomedical Research Institute aimed at repurposing an antimalarial for use against the Ebola virus.

10 Nov 2016

Exposure to licorice compound disrupts steroid sex hormone production in ovary

A study of mouse reproductive tissues finds that exposure to isoliquiritigenin, a compound found in licorice, disrupts steroid sex hormone production in the ovary, researchers report.

9 Nov 2016

New research revises scaffold definition for systematic analysis of compound diversity

While the Bemis-Murcko approach to scaffold analysis has remained the go-to definition for computational medicinal chemistry for the past few decades, it is not without its shortcomings.

9 Nov 2016

Protamine may be useful in developing new types of disinfectant solutions for contact lenses

Protamine -- a natural protein with a proven safety record -- may be useful in developing new types of disinfectant solutions for contact lenses, according to a study published in the November issue of Optometry and Vision Science, official journal of the American Academy of Optometry. The journal is published by Wolters Kluwer.

7 Nov 2016

Polysorbate slows toxic effects of E. coli poisoning

Polysorbate, a safe additive found in everything from ice cream to cosmetics, has been proven to slow the toxic effects of E. coli poisoning.

4 Nov 2016

New study finds two olfactory receptors in human lung tissue

It was always thought that olfactory receptors' sole bodily function was to smell, and could only be found inside a nose.

4 Nov 2016

TPU scientists developing bioactive coating for medical implants

A group of young scientists from Tomsk Polytechnic University are developing a bioactive coating for medical implants. Due to its properties, it will be able to "convince" the body not to reject the artificial bones and joints.

2 Nov 2016

Using deep learning to update the drug discovery paradigm: an interview with Professor Jackie Hunter

With the current drug discovery paradigm, it takes up to 15 years to translate an idea, such as hypothesizing a certain protein is important in a disease and testing this with targeting the protein with a drug, all the way through to proof of concept...

2 Nov 2016

New imaging compound could help identify signs of early-stage Alzheimer's disease

By the time unambiguous signs of memory loss and cognitive decline appear in people with Alzheimer's disease, their brains already are significantly damaged, dotted with clumps of a destructive protein known as amyloid beta.

2 Nov 2016

New study to explore therapeutic pill for treatment of concussion

The goal of finding a treatment for concussion may be one step closer due to a new study being launched by University of Miami researchers.

1 Nov 2016

Safe food additive can slow toxic effects of E. coli poisoning

Polysorbate, a safe additive found in everything from ice cream to cosmetics, has been proven to slow the toxic effects of E. coli poisoning.

1 Nov 2016

Researchers develop new way to prevent diseases caused by herpesvirus infections

A new approach has been developed to combat diseases caused by herpesvirus infections, including everything from cold sores to cancer.

1 Nov 2016

Carotenoid pigment compound reduces invasiveness of tumors in mouse models of lung cancer

Beta-cryptoxanthin (BCX), a carotenoid pigment compound found primarily in plants, reduces the number and invasiveness of tumors in mouse and cell models of lung cancer, report scientists from the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

1 Nov 2016

New research identifies mechanism that may lead to treatment of fibrosis in scleroderma

The prognosis for patients diagnosed with scleroderma - an autoimmune disease characterized by fibrosis of the skin - is not typically a rosy one. With limited treatment options available, those suffering from the disorder can face disabling hardening and tightening of their skin.

31 Oct 2016

Researchers identify potential approach for preventing neurological problems caused by blast-related TBI

More than 200,000 U.S. soldiers serving in the Middle East have experienced a blast-related traumatic brain injury, making it a common health problem and concern for that population.

31 Oct 2016

Natural compound slows typical signs of aging in mice

Much of human health hinges on how well the body manufactures and uses energy. For reasons that remain unclear, cells' ability to produce energy declines with age, prompting scientists to suspect that the steady loss of efficiency in the body's energy supply chain is a key driver of the aging process.

27 Oct 2016

Supercomputer simulations of p53 protein could boost future anti-cancer drug discovery

Even though it's almost impossible to see, computational biophysicist Rommie Amaro is using the Stampede supercomputer at the Texas Advanced Computing Center at The University of Texas at Austin to model the largest atomic level system of the tumor suppression protein p53 to date -- over 1.5 million atoms.

27 Oct 2016

Compound News and Research

De-risking drug development free webinar from Envigo

Study offers new insight into why some women have difficulty in falling pregnant

Researchers lay foundation for improved TB treatment by targeting new enzyme

NCATS funds collaboration initiative aimed at repurposing antimalarial to combat Ebola virus

Exposure to licorice compound disrupts steroid sex hormone production in ovary

New research revises scaffold definition for systematic analysis of compound diversity

Protamine may be useful in developing new types of disinfectant solutions for contact lenses

Polysorbate slows toxic effects of E. coli poisoning

New study finds two olfactory receptors in human lung tissue

TPU scientists developing bioactive coating for medical implants

Using deep learning to update the drug discovery paradigm: an interview with Professor Jackie Hunter

New imaging compound could help identify signs of early-stage Alzheimer's disease

New study to explore therapeutic pill for treatment of concussion

Safe food additive can slow toxic effects of E. coli poisoning

Researchers develop new way to prevent diseases caused by herpesvirus infections

Carotenoid pigment compound reduces invasiveness of tumors in mouse models of lung cancer

New research identifies mechanism that may lead to treatment of fibrosis in scleroderma

Researchers identify potential approach for preventing neurological problems caused by blast-related TBI

Natural compound slows typical signs of aging in mice

Supercomputer simulations of p53 protein could boost future anti-cancer drug discovery

Enhancing confidence in chemical ionization spectrometry data eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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