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Defective DNA repair mechanism linked to Huntington's disease progression

Researchers with McMaster University have discovered that the protein mutated in patients with Huntington's Disease doesn't repair DNA as intended, impacting the ability of brain cells to heal themselves.

27 Sep 2024

Study reveals rising pharmaceutical industry sponsored clinical trials in the U.S.

Researchers at Fred Hutch Cancer Center identified a substantial increase over the past decade in the proportion of patients with cancer in the U.S. who participate in pharmaceutical industry sponsored clinical trials compared to those conducted with federal government support.

27 Sep 2024

A randomized trial of mexiletine and lamotrigine in adults with non-dystrophic myotonia

The study, published in Lancet Neurology, detailed the "head-to-head" trial implemented by the researchers to test two drugs, mexiletine and lamotrigine, on people with the condition.

27 Sep 2024

Global leaders unite to tackle drug-resistant bacteria

World leaders meeting in New York have backed a new set of goals and pledged to find US$100 million in funding to address the problem of drug-resistant bacteria, a global crisis that is all the more acute in the poorest countries.

27 Sep 2024

'Treating Naturally Occurring Disease’, explained by Founder, Professor Noel Fitzpatrick

Humanimal Trust advocates for studying naturally occurring diseases in animals to advance cancer and osteoarthritis treatments for both humans and animals.

27 Sep 2024

Digital games show promise for improving ADHD and depression in youth, but anxiety remains a challenge

A meta-analysis reveals gamified digital mental health interventions effectively reduce depression and ADHD in youth, highlighting engagement in treatment.

27 Sep 2024

TxGNN improves drug repurposing by predicting treatments for rare diseases with no approved therapies

A new model, TxGNN, revolutionizes zero-shot drug repurposing by predicting treatments for diseases with no known therapies, offering improved accuracy and trust via interpretable AI explanations.

27 Sep 2024

Hormone hepcidin identified as potential trigger for psoriasis

Scientists may have uncovered the root cause of psoriasis, a chronic and sometimes debilitating skin disease that affects 2-3% of the global population. The condition is characterized by red, scaly patches that impact the quality of a patient's life and can sometimes be life-threatening.

26 Sep 2024

New insights into serine hydroxymethyltransferase aid cancer drug design

In just two neutron experiments, scientists discovered remarkable details about the function of an enzyme that can aid drug design for aggressive cancers.

26 Sep 2024

New drug MED6-189 shows promise against drug-resistant malaria

In 2022, nearly 619,000 global deaths due to malaria were caused by Plasmodium falciparum, the most virulent, prevalent, and deadly human malaria parasite.

26 Sep 2024

Review highlights evolving role of endovascular therapy in treating ischemic stroke

Stroke related to large vessel occlusion (LVO) is a leading cause of disability and death worldwide. Endovascular therapy (minimally invasive procedures like catheterization done inside the blood vessels) has transformed the management of these patients.

26 Sep 2024

Patient-derived gut organoids reveal new insights into Crohn's disease subtypes

Crohn's disease - an autoimmune disorder - is characterized by chronic inflammation of the digestive tract, resulting in a slew of debilitating gastrointestinal symptoms that vary from patient to patient.

26 Sep 2024

Antiviral drug molnupiravir linked to new mutations in SARS-CoV-2

Molnupiravir, an antiviral drug used to treat patients with COVID-19, appears to be driving SARS-CoV-2 to mutate and evolve, with some of these new viruses being transmitted onwards, a new study has shown.

26 Sep 2024

Nursing aides plagued by PTSD after ‘nightmare’ covid conditions, with little help

One evening in May, nursing assistant Debra Ragoonanan's vision blurred during her shift at a state-run Massachusetts veterans home.

26 Sep 2024

High impulsivity linked to increased stress response during boring tasks

Research at the University of Portsmouth has explored the relationship between high impulsivity and boredom, in an effort to find out what drives rash and sometimes unhealthy decisions.

26 Sep 2024

Targeted therapy improves pregnancy outcomes

Amongst women who experience recurrent pregnancy loss, around 20% test positive for a specific antibody that targets the mother's own body. A Kobe University-led research team now found a treatment that drastically increases these women's chances of carrying to full-term without complications.

26 Sep 2024

Drugs News and Research

Defective DNA repair mechanism linked to Huntington's disease progression

Study reveals rising pharmaceutical industry sponsored clinical trials in the U.S.

A randomized trial of mexiletine and lamotrigine in adults with non-dystrophic myotonia

Global leaders unite to tackle drug-resistant bacteria

'Treating Naturally Occurring Disease’, explained by Founder, Professor Noel Fitzpatrick

Digital games show promise for improving ADHD and depression in youth, but anxiety remains a challenge

TxGNN improves drug repurposing by predicting treatments for rare diseases with no approved therapies

Hormone hepcidin identified as potential trigger for psoriasis

New insights into serine hydroxymethyltransferase aid cancer drug design

New drug MED6-189 shows promise against drug-resistant malaria

Review highlights evolving role of endovascular therapy in treating ischemic stroke

Patient-derived gut organoids reveal new insights into Crohn's disease subtypes

Antiviral drug molnupiravir linked to new mutations in SARS-CoV-2

Nursing aides plagued by PTSD after ‘nightmare’ covid conditions, with little help

High impulsivity linked to increased stress response during boring tasks

Targeted therapy improves pregnancy outcomes

Researchers explore new metabolic pathway to fight cancer

New pipeline of drug candidates offers hope for effective MASLD treatments

Concerns raised over safety and effectiveness of donanemab for Alzheimer’s treatment

Study sheds light on mechanisms behind liver fibrosis and potential therapies

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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