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Research provides a comprehensive map of exercise-induced signaling molecules present in the tissues

It is well established that exercise improves health, and recent research has shown that exercise benefits the body in different ways, depending on the time of day. But scientists still do not know why the timing of exercise produces these different effects.

17 Jan 2022

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

A new study, published in the journal Cell Chemical Biology, has reported the discovery of acriflavine (ACF), an effective inhibitor of SARS-CoV-2. This drug is a mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinium chloride) and proflavine (3,6-diaminoacridine).

16 Jan 2022

Virus-like particles as delivery vehicles for gene-editing

Scientists deliver gene-editing proteins through the use of engineered virus-like particles, which mediated efficient base editing both in vitro and in vivo.

13 Jan 2022

Role of leptin in immune modulation and pathophysiology of COVID-19

A recent review paper in the journal Frontiers in Physiology discusses the role of leptins in infection with SARS-CoV-2 that triggered the ongoing COVID-19 pandemic.

13 Jan 2022

Using lab-grown stomachs to shed light on the symptoms of COVID-19

Could lab-grown 'mini-stomachs' be used to look at COVID-19 symptoms in children? In this interview, we speak to Paolo De Coppi to find out more.

13 Jan 2022

ASTRO provides new guidance on the use of external beam radiation therapy for primary liver cancers

A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides guidance on the use of radiation therapy to treat adult patients with primary liver cancers using external beam radiation therapy (EBRT).

12 Jan 2022

Ketamine plus psychological therapy can help people stay off alcohol for longer time

People with severe alcohol disorder were able to stay off alcohol for longer when they were treated with low doses of ketamine combined with psychological therapy in a clinical trial.

11 Jan 2022

Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

Biliary atresia is a rare disease that occurs when a delicate tree-like set of ducts that carry bile from the liver to the intestine becomes scarred and blocked. While some treatments can slow the damage, most children who develop biliary atresia will die without a liver transplant.

10 Jan 2022

SARS-CoV-2 Delta sublineage AY.4.2 shows no increase in cell entry or antibody evasion

Researchers from Germany, in their recent study published in the journal Cellular & Molecular Immunology, have evaluated the mutations in the S protein of one such SARS-CoV-2 strain, a Delta sublineage AY.4.2, which is currently expanding in the UK, and have found that it neither contains any potential for increased cell entry nor antibody escape.

10 Jan 2022

Engineering hairy cellulose nanocrystals to capture chemotherapy drugs

Millions of people around the globe are affected by cancer each year; more than 39% of men and women are diagnosed with cancer during their lifetime.

7 Jan 2022

Booster mRNA vaccination effective in reviving anti-SARS-CoV-2 antibody titers among the elderly

A new study found that a booster dose vaccination against COVID-19 was successful in taking binding. and neutralizing antibodies to levels higher than those observed after the initial double-dose regimen.

7 Jan 2022

Association of obstructive sleep apnea with hospitalization due to COVID-19

Researchers report that OSA is an independent risk factor for severe COVID-19.

7 Jan 2022

New research may help better understand the causes of human diseases

New University of Gloucestershire research aims to increase our understanding of the causes of human diseases, potentially leading to the design of better treatments in the future.

7 Jan 2022

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

An experimental immunotherapy can temporarily reprogram patients' immune cells to attack a specific target via only a single injection of messenger RNA (mRNA), similar to the mRNA-based COVID-19 vaccines, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

6 Jan 2022

New engineered nanomaterials help capture chemotherapy drugs to avoid tissue damage

Standard chemotherapies may efficiently kill cancer cells, but they also pose significant risks to healthy cells, resulting in secondary illness and a diminished quality of life for patients. To prevent the previously unavoidable damage, researchers, led by Penn State, have developed a new class of nanomaterials engineered to capture chemotherapy drugs before they interact with healthy tissue.

6 Jan 2022

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

The LIVE-AIR phase 3 clinical trial is associated with early treatment of hyperinflammatory response with the humanized monoclonal antibody lenzilumab in COVID-19 patients with decreased oxygen saturation. The study results are posted to the medRxiv* preprint server.

6 Jan 2022

Liver News and Research

Research provides a comprehensive map of exercise-induced signaling molecules present in the tissues

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

Virus-like particles as delivery vehicles for gene-editing

Role of leptin in immune modulation and pathophysiology of COVID-19

Using lab-grown stomachs to shed light on the symptoms of COVID-19

ASTRO provides new guidance on the use of external beam radiation therapy for primary liver cancers

Ketamine plus psychological therapy can help people stay off alcohol for longer time

Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

SARS-CoV-2 Delta sublineage AY.4.2 shows no increase in cell entry or antibody evasion

Engineering hairy cellulose nanocrystals to capture chemotherapy drugs

Booster mRNA vaccination effective in reviving anti-SARS-CoV-2 antibody titers among the elderly

Association of obstructive sleep apnea with hospitalization due to COVID-19

New research may help better understand the causes of human diseases

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

New engineered nanomaterials help capture chemotherapy drugs to avoid tissue damage

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

New gene therapy addresses primary cellular deficit associated with limb-girdle muscular dystrophy 2B

Both symptomatic and asymptomatic COVID-19 associated with increased risk of cardiovascular events

New Better Health marketing campaign highlights six benefits of losing excess weight

Olfactory receptor gene may play a role in breast cancer metastasis to the brain

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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