Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Researchers identify new therapeutic targets for kidney fibrosis

Chronic kidney disease is a global health concern, affecting about 10 percent of the world's population--and increasing in prevalence. A final, common pathway in chronic kidney disease is fibrosis.

29 Jan 2019

Binge and heavy drinking may change DNA, resulting in greater desire for alcohol

Binge and heavy drinking may trigger a long-lasting genetic change, resulting in an even greater craving for alcohol, according to a Rutgers-led study in the journal Alcoholism: Clinical & Experimental Research.

29 Jan 2019

EZH2 mutations can be used as marker for diagnosing different types of cancers

Inside the cell, DNA is tightly wrapped around proteins and packed in a complex, 3D structure that we call "chromatin".

29 Jan 2019

NIH grants awarded to Nanoscope to recruit talent and develop optogenetic delivery platforms

Retinal dystrophies such as Age-related macular degeneration (AMD) are a major cause of vision loss in aging populations. National Eye Institute (NEI) estimates that the prevalence of advanced AMD will grow to nearly 3 million by 2020.

29 Jan 2019

New class of antisense oligonucleotide therapeutics tested in humans

A first-in-human study with a new class of antisense oligonucleotide therapeutics showed the ability to target the RNA-silencing drug to the liver, resulting in improved potency and safety at therapeutic doses. The design and results of this trial, conducted in healthy human volunteers are reported in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers.

28 Jan 2019

Stress and paradoxical sleep associated with pathways of brain cell death and survival

The first and most distinct consequence of daily mild stress is an increase in rapid-eye-movement (REM) sleep, a new study in the journal PNAS reports. The research also demonstrated that this increase is associated with genes involved in cell death and survival.

28 Jan 2019

Researchers create synthetic growth factor that offers comparable biological response

Growth factors are ligands that play important roles in the body - they are responsible for tissue regeneration, wound healing, and the maintenance and growth of cells.

28 Jan 2019

Scientists pinpoint mechanism that leads to steroid diabetes

Patients undergoing long-term treatment with steroids may suffer from metabolic side effects. Researchers at the Helmholtz Zentrum München and the Ludwig Maximilians University of Munich, partners in the German Center for Diabetes Research, have now pinpointed a mechanism that leads to so-called steroid diabetes

25 Jan 2019

Discovery could guide future treatments for patients with hypertension

A team of Vanderbilt University Medical Center researchers, working with the U.S. Department of Veteran's Affairs, has discovered genetic associations with blood pressure that could guide future treatments for patients with hypertension.

25 Jan 2019

PET imaging post-HBOT shows improvement in brain metabolism in Alzheimer’s disease

Dr. Paul Harch, Clinical Professor and Director of Hyperbaric Medicine at LSU Health New Orleans School of Medicine, and Dr. Edward Fogarty, Chairman of Radiology at the University of North Dakota School of Medicine, report the first PET scan-documented case of improvement in brain metabolism in Alzheimer's disease in a patient treated with hyperbaric oxygen therapy.

24 Jan 2019

Study sheds new light on male infertility

Hope has emerged for infertile men as scientists at Newcastle University have understood the importance of a gene in regulating the production of fully-functioning sperm.

24 Jan 2019

Ludwig researchers find ways to make resistant melanomas susceptible to immunotherapy

A Ludwig Cancer Research study has uncovered a cellular mechanism by which melanomas that fail to respond to checkpoint blockade may be made susceptible to such immunotherapies.

23 Jan 2019

Scientists have reversed memory loss in a mouse model of Alzheimer’s Disease

Using a new epigenetics-based approach, scientists have managed to reduce memory loss and improve cognitive function in a mouse model of Alzheimer’s disease.

22 Jan 2019

Researchers show how mechanical stress affects bone development

Researchers at Okayama University show how mechanical stress at very early stages of bone development alters expression pattern of the non-collagenous matrix responsible for biological property of the bone.

22 Jan 2019

Mice transmit brain benefits of enriched upbringing to non-enriched offspring

Mice growing up in a basic cage maintain lifelong visual cortex plasticity if their parents were raised in an environment that promoted social interaction and physical and mental stimulation, according to a multigenerational study published in eNeuro.

From Society for Neuroscience 22 Jan 2019

Study describes metabolism of intestinal microbiota in babies for the first time

A research team with the participation of the Institute for Integrative Systems Biology of the University of Valencia, together with FISABIO and CIBERESP, has carried out the first metatranscriptomic study of the gut microbiota of babies, which has allowed to unveil the metabolism of the intestinal bacterial community during the first year of life, with a level of detail unknown until now

22 Jan 2019

Molecular profiling of precancerous lung lesions could lead to early detection and new treatments

The world's first genetic sequencing of precancerous lung lesions could pave the way for very early detection and new treatments, reports a new study led by UCL researchers.

21 Jan 2019

Study reveals new genes and biological pathways linked to osteoarthritis

In the largest genetic study of osteoarthritis, an international team of scientists including researchers from the University of Sheffield, have uncovered 52 new genetic changes linked to the disease, which doubles the number of genetic regions associated with the disabling condition.

21 Jan 2019

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Researchers at A*STAR's Singapore Bioimaging Consortium have discovered that branched-chain amino acids in tumors can be targeted to prevent and treat cancer. Together with collaborators from the United States and National Cancer Centre Singapore, they found that some cancers potently suppress the catabolism (breakdown) of BCAAs.

21 Jan 2019

Study: Male and female differences in fear memory is attributed to Cdk5 gene

In a mouse model of traumatic memory, male mice recall fear-related memories better than female mice, according to a study in Biological Psychiatry. The difference between sexes was attributed to a gene important for creating fear memories and stress behavior, called cyclin dependent kinase 5, which was naturally activated in male but not in female mice.

18 Jan 2019

Gene Expression News and Research

Further Reading

Researchers identify new therapeutic targets for kidney fibrosis

Binge and heavy drinking may change DNA, resulting in greater desire for alcohol

EZH2 mutations can be used as marker for diagnosing different types of cancers

NIH grants awarded to Nanoscope to recruit talent and develop optogenetic delivery platforms

New class of antisense oligonucleotide therapeutics tested in humans

Stress and paradoxical sleep associated with pathways of brain cell death and survival

Researchers create synthetic growth factor that offers comparable biological response

Scientists pinpoint mechanism that leads to steroid diabetes

Discovery could guide future treatments for patients with hypertension

PET imaging post-HBOT shows improvement in brain metabolism in Alzheimer’s disease

Study sheds new light on male infertility

Ludwig researchers find ways to make resistant melanomas susceptible to immunotherapy

Scientists have reversed memory loss in a mouse model of Alzheimer’s Disease

Researchers show how mechanical stress affects bone development

Mice transmit brain benefits of enriched upbringing to non-enriched offspring

Study describes metabolism of intestinal microbiota in babies for the first time

Molecular profiling of precancerous lung lesions could lead to early detection and new treatments

Study reveals new genes and biological pathways linked to osteoarthritis

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Study: Male and female differences in fear memory is attributed to Cdk5 gene

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