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Damage to DNA in sperm is significantly higher in older men

Damage to DNA in sperm is significantly higher in older men than in those who are younger, according to research presented today (Tuesday 21 June 2005) at the 21st annual conference of the European Society of Human Reproduction and Embryology.

20 Jun 2005

Most common form of lung cancer may begin in a group of newly isolated lung stem cells

Working in a mouse model, the researchers isolated a novel type of lung cell that can divide into fresh copies of itself and into the two more specialized kinds of cells deep in the lung.

16 Jun 2005

Nanotechnology used to smuggle a powerful chemotherapeutic drug inside tumor cells

University of Michigan scientists have created the nanotechnology equivalent of a Trojan horse to smuggle a powerful chemotherapeutic drug inside tumor cells - increasing the drug's cancer-killing activity and reducing its toxic side effects.

15 Jun 2005

New technology developed at Cornell University could make it just as easy to identify genes

A supermarket checkout computer can identify thousands of different items by scanning the tiny barcode printed on the package. New technology developed at Cornell University could make it just as easy to identify genes, pathogens, illegal drugs and other chemicals of interest by tagging them with color-coded probes made out of synthetic tree-shaped DNA.

14 Jun 2005

Fundamental insights in how amyloid fibers form

Amyloid fibers are best known as the plaque that gunks up neurons in people with neurodegenerative illnesses such as Alzheimer's and Creutzfeldt-Jacob disease--the human analog of mad cow disease.

9 Jun 2005

New study shows tiny RNAs intimately associated with cancer

In discoveries that may open a new chapter in understanding and diagnosing cancer, Howard Hughes Medical Institute (HHMI) investigators and their colleagues have established that tiny microRNAs provide a novel genetic route to the initiation of some forms of cancer.

9 Jun 2005

Several minute intermediate stage in virus-cell fusion may represent a window of opportunity for drug development

To ignite a life-threatening infection in the body, a virus such as HIV invades body cells by first merging, or fusing, with the cell's outer membrane. Once inside the cell, the invading microbe's genetic material takes over, turning the 'host' cell into a factory to produce more copies of the virus, which then spill out to invade other cells in the body.

8 Jun 2005

Technology for analyzing gene expression must be standardized

Technology for analyzing gene expression must be standardized among laboratories and across platforms around the world to support this age of human genome exploration, an Oregon Health & Science University researcher says.

29 May 2005

Discovery may lead to therapies to treat the neurological disease

Opening a window to understand the molecular basis of a hereditary ataxia, Dartmouth Medical School researchers have identified an enzyme activity that is inactivated in all reported mutant forms of a disease protein. The discovery may lead to therapies to treat the neurological disease.

29 May 2005

Fluorescence device to diagnose atherosclerosis and tumors

In a presentation at the Conference on Lasers and Electro-Optics (CLEO), researchers from Cedars-Sinai Medical Center's Biophotonics Research and Technology Development Laboratory described recent progress on a device that stimulates, collects and measures light emissions from body tissues to diagnose critical atherosclerotic plaques (vulnerable plaques) and aggressive brain tumors.

29 May 2005

Tiny fluorescent crystals barely visible to the human eye that could revolutionise cancer diagnosis

Scientists funded by the Association for International Cancer Research have developed tiny fluorescent crystals barely visible to the human eye that could revolutionise cancer diagnosis and treatment in a big way.

26 May 2005

Scientists watch agents of brain-wasting diseases invade and move within brain cells

Scientists for the first time have watched agents of brain-wasting diseases, called transmissible spongiform encephalopathies (TSE), as they invade a nerve cell and then travel along wire-like circuits to points of contact with other cells.

25 May 2005

New insight into the machinery cells use to internalize cell surface receptors

Using state of the art imaging technology a team from Yale School of Medicine has glimpsed one of the cell's most important 'nano-machines' in action. The work, performed in collaboration with English and French scientists, provides new insight into the machinery cells use to internalize cell surface receptors.

22 May 2005

Embryonic body wash controls left-right development

Humans and other animals may appear to be symmetrical on the outside, but symmetry is only skin deep. Many body organs, such as the stomach, the heart and the liver, are tipped to the right or left side. So how does the developing embryo distinguish left from right?

20 May 2005

Mosaic Analysis with Double Markers (MADM) - A powerful new tool to study diseases and genetics

A powerful laboratory technique used by fruit fly geneticists for more than a decade is now available to scientists studying genes and diseases in mice.

5 May 2005

Two-photon imaging gives real-time video of cells in living tissue

Biologists have a new tool to track and videotape cells moving about inside living tissue.

3 May 2005

Study identifies possible marker for efficacy of gefitinib in lung cancer patients

Patients with advanced non–small-cell lung cancer (NSCLC) whose tumor cells contain extra copies of the epidermal growth factor receptor (EGFR) gene may be more likely to respond to the drug gefitinib (Iressa), and this high gene copy number may be an effective predictor of gefitinib efficacy, according to a new study in the May 4 issue of the Journal of the National Cancer Institute.

3 May 2005

Pulsating ultrasound enhances gene therapy for tumors

High-intensity focused ultrasound emitted in short pulses is a promising, non-invasive procedure for enhancing gene delivery to cancerous cells without destroying healthy tissue, according to a study in the May issue of the journal Radiology.

26 Apr 2005

New strategy to identify differences between non-metastatic and highly metastatic breast cancer cells

Researchers at the University of California, San Diego have used a new strategy to identify differences between non-metastatic and highly metastatic breast cancer cells. The article by Valerie Montel et al., "Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model," appears in the May 2005 issue of The American Journal of Pathology and is accompanied by a commentary.

22 Apr 2005

First time video capture of chemical signals that traverse human cells messaging

Researchers at UCSD and UC Irvine have captured on video for the first time chemical signals that traverse human cells in response to tiny mechanical jabs, like waves spreading from pebbles tossed into a pond. The scientists released the videos and technical details that explain how the visualization effect was created as part of a paper published in the April 21 issue of Nature.

21 Apr 2005

Fluorescence News and Research

Damage to DNA in sperm is significantly higher in older men

Most common form of lung cancer may begin in a group of newly isolated lung stem cells

Nanotechnology used to smuggle a powerful chemotherapeutic drug inside tumor cells

New technology developed at Cornell University could make it just as easy to identify genes

Fundamental insights in how amyloid fibers form

New study shows tiny RNAs intimately associated with cancer

Several minute intermediate stage in virus-cell fusion may represent a window of opportunity for drug development

Technology for analyzing gene expression must be standardized

Discovery may lead to therapies to treat the neurological disease

Fluorescence device to diagnose atherosclerosis and tumors

Tiny fluorescent crystals barely visible to the human eye that could revolutionise cancer diagnosis

Scientists watch agents of brain-wasting diseases invade and move within brain cells

New insight into the machinery cells use to internalize cell surface receptors

Embryonic body wash controls left-right development

Mosaic Analysis with Double Markers (MADM) - A powerful new tool to study diseases and genetics

Two-photon imaging gives real-time video of cells in living tissue

Study identifies possible marker for efficacy of gefitinib in lung cancer patients

Pulsating ultrasound enhances gene therapy for tumors

New strategy to identify differences between non-metastatic and highly metastatic breast cancer cells

First time video capture of chemical signals that traverse human cells messaging

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