Liver Disease News and Research

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The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.

New drug approved for treating endometriosis

Drug manufacturer Pfizer announced today that the U.S. Food and Drug Administration (FDA) has given approval for the release of depo-subQ provera 104 to be prescribed for the management of pain associated with endometriosis, a gynecological condition that affects one in ten women of reproductive age.

30 Mar 2005

Patients with Hepatitis C have a significant decrease in their health-related quality-of-life

Patients with Hepatitis C virus (HCV) have a significant decrease in their health-related quality-of-life (HRQOL), although treatment success can mitigate this negative effect.

28 Mar 2005

Statins appear to be safe for people with fatty liver disease

Statins appear to be safe for people with fatty liver disease who could benefit from their cholesterol-lowering capabilities, concludes a review paper published in the April 2005 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD).

28 Mar 2005

Three risk factors have the greatest impact on patient and graft survival rates for liver transplantation

Three risk factors: donor age; the length of time an organ is cooled between procurement and transplantation; and how urgently the recipient needs the transplant; have the greatest impact on patient and graft survival rates for liver transplantation, according to an article in the March issue of Archives of Surgery.

22 Mar 2005

Alcohol relapse adversely affects liver transplant survival

A new study on how alcohol relapse affects survival rates after liver transplants found that it adversely affected survival rates only after 10 years. The decrease in survival rates may, however, be due to other alcohol-related diseases.

22 Mar 2005

Patients can now swallow pill-sized, disposable cameras to help diagnose diseases of the esophagus

Patients can now swallow pill-sized, disposable cameras to help gastroenterologists diagnose and evaluate diseases of the esophagus, or swallowing tube. This new diagnostic tool is a further modification of capsule endoscopy, which has been used clinically since late 2001 to examine the small intestines.

15 Mar 2005

New hepatitis drug wins approval by FDA

An experimental hepatitis B drug has earned the praise of US health experts for its effectiveness and has been recommended by the US Food and Drug Administration (FDA) advisory panel to treat the liver disease in adults.

14 Mar 2005

Diabetic patients run three times the risk of developing liver cancer

The researchers trawled a surveillance database used for patients in receipt of Medicare funding for health care, to identify patients aged 65 and older, who had been diagnosed with liver cancer.

7 Mar 2005

New therapeutic targets in liver diseases

Many patients with liver diseases often encounter difficulties with therapy and ultimately require liver transplant to survive. Since many acute and chronic liver diseases are driven by immune-mediated mechanisms, there is a necessity to find new therapies that can inhibit these immune-based triggers and block liver damage.

6 Mar 2005

Pfizer acquires Idun Pharmaceuticals

Pfizer today announced that it has entered into an agreement to acquire Idun Pharmaceuticals, a biopharmaceutical company focused on the discovery and development of therapies to control apoptosis, a process of cell death that occurs in a broad range of diseases.

24 Feb 2005

Scientists have replicated hepatitis C virus (HCV) in the laboratory

For the first time, scientists have replicated hepatitis C virus (HCV) in the laboratory. The ability to replicate HCV in cell culture will allow researchers to better study the life cycle and biology of this virus and to test potential antiviral compounds, which may lead to new therapies for the liver disease that results from infection with HCV.

22 Feb 2005

Pitt researcher presents findings on when to accept organ transplants

A transplant is the only option for someone with end-stage liver disease, but patients face difficult questions when choosing the best time to receive a transplant.

20 Feb 2005

Biochemical marker aids prognosis in liver transplant patients

A new study on whether the model used to identify patients most in need of a liver transplant can be improved upon found that measuring serum sodium in potential transplant patients helps to better predict those with a poor prognosis.

20 Feb 2005

Nonsurgical microspheres an option for liver cancer patients

A study in February’s Journal of Vascular and Interventional Radiology found that patients undergoing liver cancer treatment with Theraspheres?, radioactive microspheres containing Yittrium-90, can tolerate a 150 Gy single dose or 268 Gy repeated dose without risk of radiation-induced liver disease.

17 Feb 2005

Eleventh Edition of the Report on Carcinogens

The Department of Health and Human Services released its Eleventh Edition of the Report on Carcinogens today, adding seventeen substances to the growing list of cancer-causing agents, bringing the total to 246.

31 Jan 2005

VCU Gastroenterology research papers ranked 4th in most cited papers

Virginia Commonwealth University’s School of Medicine has been ranked fourth among federally funded U.S. universities based on the average number of citations per research paper published in indexed journals of gastroenterology and hepatology between 1999 and 2003.

26 Jan 2005

Severity of liver disease not a reliable indicator of quality of life

A new study on the determination of how livers are allocated for transplants examined the relationship between liver disease severity and quality of life, and found that the commonly used model for liver allocation is not a reliable indicator of general quality of life.

24 Jan 2005

Role of ethnicity in nonalcoholic fatty liver disease

The first study to examine nonalcoholic fatty liver disease (NAFLD) among different ethnic and racial groups in the United States finds that Hispanics may be at a higher risk of developing the condition. The study is published in Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc., Hepatology is available online via Wiley InterScience.

19 Jan 2005

Sildenafil restores cognitive function in rats after liver failure

A study involving rats reveals the mechanism responsible for learning impairment due to liver failure and shows that sildenafil restores cognitive function.

19 Jan 2005

Major partnership with National Institute of Allergy and Infectious Diseases for Narhex Life Sciences

Australian drug specialist Narhex Life Sciences, has announced a partnership with one of the world’s foremost US medical research centres to evaluate its protease inhibitor Nar DG 35 Prodrug for its activity against Hepatitis C and SARS viruses.

12 Jan 2005