Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Mitochondrial DNA copy number appears to be predictive of sudden cardiac death, heart attacks

Johns Hopkins researchers report that the level, or "copy number," of mitochondrial DNA--genetic information stored not in a cell's nucleus but in the body's energy-creating mitochondria--is a novel and distinct biomarker that is able to predict the risk of heart attacks and sudden cardiac deaths a decade or more before they happen.

11 Oct 2017

Scientists develop new method for monitoring lipolysis by testing person's exhaled breath

Experts advise anyone looking to shed extra kilos to eat less and exercise more. One way is with endurance training, during which the body burns not only carbohydrates such as sugar, but also fat.

10 Oct 2017

Study: Ovarian reserve tests do not appear to predict short-term chances of conception

Tests that estimate ovarian reserve, or the number of a woman's remaining eggs, before menopause, do not appear to predict short-term chances of conception, according to a National Institutes of Health-funded study of women with no history of infertility.

10 Oct 2017

New $7.6 million NIA grant awarded to IU for Longitudinal Early-onset AD Study

Indiana University School of Medicine has been awarded a one-year, $7.6 million grant from the National Institute on Aging to establish a network of sites to study early-onset Alzheimer's disease.

9 Oct 2017

Genetic signature within prostate cancer cells can predict metastatic tumors

Many prostate cancers, which generally are diagnosed in older men, are "indolent," slow-growing tumors that aren't destined to be fatal. But some tumors are prone to becoming aggressive and spreading beyond the prostate, making them difficult to treat and life-threatening.

6 Oct 2017

Study uncovers differences in bacterial composition of healthy vs. cancerous breast tissue

In a newly published study, Cleveland Clinic researchers have uncovered differences in the bacterial composition of breast tissue of healthy women vs. women with breast cancer.

6 Oct 2017

New urine test accurately detects patients at risk for kidney damage after heart surgery

A new, inexpensive urine test accurately identifies patients at risk for kidney damage after open heart surgery, allowing for corrective action before permanent injury occurs, according to research presented today at the 14th Annual Multidisciplinary Cardiovascular and Thoracic Critical Care Conference from The Society of Thoracic Surgeons.

5 Oct 2017

New non-invasive biomarker detects Alzheimer's disease before occurrence of first symptoms

Absence of a prefrontal activation during sensory gating of simple tones detects the Alzheimer's disease (AD) before the occurrence of the first symptoms. Sanja Josef Golubic Ph.D., physicists at the Department of Physics, Faculty of Science, University of Zagreb, reveals the high potential, absolutely non-invasive biomarker of AD pathology in a new study published in the journal Human Brain Mapping. Josef Golubic found a discrete, individual biomarker of AD with "ideal" properties.

3 Oct 2017

Liquid biopsy can reveal response to checkpoint inhibitor-based immunotherapies

In a first-of-its-kind study, University of California San Diego School of Medicine researchers report that a blood sample, or liquid biopsy, can reveal which patients will respond to checkpoint inhibitor-based immunotherapies.

3 Oct 2017

Alterations in circulating tumor DNA associated with response to checkpoint inhibitors

The number of alterations detected in the DNA collected from blood samples (liquid biopsies) of cancer patients treated with immune checkpoint inhibitors was associated with response to the treatment.

3 Oct 2017

Benefits of Biomarkers in Colorectal Cancer Treatment

Biomarkers fall into different categories: diagnostic biomarkers, are used to identify a disease; prognostic biomarkers, help clinicians to determine, for example, whether you're more likely to die or have problems with a disease; and there are some that can be used to inform treatment, to determine whether one therapy would be more successful than another.

2 Oct 2017

Blood test may predict treatment outcomes for patients with localized NSCLC

A new study demonstrates that a blood test to detect cancer may predict treatment outcomes for patients with localized non-small cell lung cancer (NSCLC) and afford physicians additional lead time to personalize treatment for recurrent disease.

28 Sep 2017

Study identifies potential biomarker for onset, progression of MS

An article published in Experimental Biology and Medicine identifies Opioid Growth Factor (OGF) as a novel biomarker for the onset and progression of multiple sclerosis (MS).

27 Sep 2017

Prescription drug linked to marked slowing of stomach emptying and weight loss

Liraglutide injection, a prescription medication used to treat type-2 diabetes and obesity is associated with marked slowing of stomach emptying and is an effective weight loss therapy. These are the findings of a randomized, double-blind, placebo-controlled study by Mayo Clinic researchers published today in The Lancet Gastroenterology & Hepatology.

26 Sep 2017

Novel assay shows potential to detect circulating cancer biomarkers in blood samples

Future Science Group today announced the publication of an article in Future Science OA presenting early data from a novel assay for the non-invasive detection of PD-L1 and other biomarkers in patient blood samples.

22 Sep 2017

Researchers identify new genetic test to help predict cancer recurrence

Researchers have discovered a new genetic test which could help predict cancer recurrence - paving the way for more precise, personalized treatments.

21 Sep 2017

Novel technology holds promise for improving accuracy of type 1 diabetes tests

Researchers from the Johns Hopkins University School of Medicine, Stanford University and the University of Florida report the development of a novel antibody detection technology that holds promise for improving the accuracy of diagnostic tests for type 1 diabetes in young children and making populationwide screening practical.

13 Sep 2017

Nanoparticle bling could increase sensitivity of test strips for better cancer detection

The most common test strip people might think of for diagnosis is a home pregnancy test. Pregnant women have steadily increasing levels of the biomarker human chorionic gonadotropin (hCG), which is easily detectable in urine and a thin, colorful strip of antibodies will appear when hCG is present.

13 Sep 2017

‘Nanoswitches’ could be key to faster, more sensitive tests for detection of biomarkers

Engineered strands of DNA -- nanoscale tools called "nanoswitches" -- could be the key to faster, easier, cheaper and more sensitive tests that can enable high-fidelity detection of biomarkers indicating the presence of different diseases, viral strains and even genetic variabilities as subtle as a single-gene mutation.

12 Sep 2017

Antibody therapy found effective in subgroup of patients with treatment-resistant COPD

An antibody treatment reduces the rate of flare-ups by nearly 20 percent in patients with a subgroup of treatment-resistant chronic obstructive pulmonary disease (COPD), according to the results of two large international trials presented today at the European Respiratory Society International Congress in Milan, Italy, and simultaneously published in the New England Journal of Medicine.

12 Sep 2017

Biomarker News and Research

Further Reading

Mitochondrial DNA copy number appears to be predictive of sudden cardiac death, heart attacks

Scientists develop new method for monitoring lipolysis by testing person's exhaled breath

Study: Ovarian reserve tests do not appear to predict short-term chances of conception

New $7.6 million NIA grant awarded to IU for Longitudinal Early-onset AD Study

Genetic signature within prostate cancer cells can predict metastatic tumors

Study uncovers differences in bacterial composition of healthy vs. cancerous breast tissue

New urine test accurately detects patients at risk for kidney damage after heart surgery

New non-invasive biomarker detects Alzheimer's disease before occurrence of first symptoms

Liquid biopsy can reveal response to checkpoint inhibitor-based immunotherapies

Alterations in circulating tumor DNA associated with response to checkpoint inhibitors

Benefits of Biomarkers in Colorectal Cancer Treatment

Blood test may predict treatment outcomes for patients with localized NSCLC

Study identifies potential biomarker for onset, progression of MS

Prescription drug linked to marked slowing of stomach emptying and weight loss

Novel assay shows potential to detect circulating cancer biomarkers in blood samples

Researchers identify new genetic test to help predict cancer recurrence

Novel technology holds promise for improving accuracy of type 1 diabetes tests

Nanoparticle bling could increase sensitivity of test strips for better cancer detection

‘Nanoswitches’ could be key to faster, more sensitive tests for detection of biomarkers

Antibody therapy found effective in subgroup of patients with treatment-resistant COPD

Event guide: 15th World Clinical Biomarkers & CDx Europe eBook

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