Clinical Trial News and Research

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Study reviews mechanistic data on new methods of allergy prevention and treatment

In a recent article published in Science Translational Medicine, researchers reviewed the cause and the underlying pathophysiology of allergic diseases.

23 Jan 2023

New research evaluates clinical trials investigating post-acute COVID-19 syndrome treatment

In a recent article published in Clinical Microbiology and Infection, researchers reviewed all registered trials currently investigating potential treatment options for post-acute coronavirus disease 2019 (COVID-19) syndrome (PACS).

23 Jan 2023

What was the prevalence of adverse events following first and second dose COVID-19 vaccinations in England?

A recent Eurosurveillance study focused on estimating the incidence of a prespecified list of adverse events following the first and second doses of the COVID-19 vaccination.

23 Jan 2023

Using motion capture technology and AI to monitor the progression of movement disorders

A multi-disciplinary team of researchers has developed a way to monitor the progression of movement disorders using motion capture technology and AI.

23 Jan 2023

Scientists reveal why common anti-depressants cause emotional ‘blunting’ in users

Scientists have worked out why common anti-depressants cause around a half of users to feel emotionally 'blunted'.

23 Jan 2023

Phase I trial results from AdaptVac's COVID capsid virus-like particle vaccine

In a recent study published in The Lancet Microbe journal, researchers described the effectiveness of a modular capsid virus-like coronavirus disease 2019 (COVID-19) vaccination.

22 Jan 2023

Four-drug chemotherapy regimen provides longer overall survival for metastatic pancreatic ductal adenocarcinoma

A four-drug chemotherapy regimen provided longer overall survival than a two-drug combination in a Phase 3 clinical trial for metastatic pancreatic ductal adenocarcinoma.

20 Jan 2023

Addition of nab-paclitaxel to gemcitabine/cisplatin does not improve overall survival of patients with advanced biliary tract cancers

Adding nab-paclitaxel to a standard treatment of gemcitabine plus cisplatin does not significantly extend median overall survival (OS) time for patients with advanced biliary tract cancers, although it may provide a benefit for subsets of patients with locally advanced disease or gallbladder adenocarcinoma.

20 Jan 2023

Researchers create the first 'living medicine' to treat drug-resistant lung infections

Researchers have designed the first 'living medicine' to treat lung infections. The treatment targets Pseudomonas aeruginosa, a type of bacteria which is naturally resistant to many types of antibiotics and is a common source of infections in hospitals.

19 Jan 2023

Team-oriented approach improves the risk of acquiring post-procedural acute kidney injury

Findings from a new study published in The Clinical Journal of the American Society of Nephrology, involving a collaborative effort between researchers at Dartmouth's Geisel School of Medicine, Vanderbilt, and Veteran's Affairs (VA) medical centers, show that an implementation science approach using team-based coaching and automated surveillance reporting significantly improves the risk of acquiring post-procedural acute kidney injury (AKI) when compared to other interventions.

19 Jan 2023

Vaccinated women well protected against severe COVID-19 symptoms, complications during pregnancy

The global network led by the Oxford Maternal and Perinatal Health Institute (OMPHI) at the University of Oxford has today published, in the Lancet, the results of the '2022 INTERCOVID Study' conducted in 41 hospitals across 18 countries.

19 Jan 2023

New scan reliably detects primary aldosteronism, a common cause of hypertension

In a recent article, researchers performed a prospective within-patient clinical trial, Is Metomidate superior to AVS in predicting ouTComes from adrenalectomy in primary Hyperaldosteronism (MATCH) in the United Kingdom (UK) in primary aldosteronism (PA) patients. These patients suffered from high blood pressure caused by a steroid hormone, aldosterone.

19 Jan 2023

Group-based CBT relieves psychological distress, improves quality of life in younger heart patients

Group therapy relieves psychological distress, improves quality of life and results in fewer readmissions for heart problems, according to a study published today in European Heart Journal, a journal of the European Society of Cardiology.

18 Jan 2023

Investigational vaccine regimen safe but did not provide protection against HIV acquisition

An investigational HIV vaccine regimen tested among men who have sex with men (MSM) and transgender people was safe but did not provide protection against HIV acquisition, an independent data and safety monitoring board (DSMB) has determined.

18 Jan 2023

What does the future of clinical trials and evidence-based medicine look like?

In a recent perspective published in Nature Medicine, the researcher shared his vision and future perspectives for the domains of clinical research and evidence-based therapeutics.

18 Jan 2023

The efficacy of low-dose fluvoxamine compared with placebo for treating mild to moderate COVID-19 in the US

Researchers evaluated the efficacy of low-dosage fluvoxamine (50 mg two times a day) over 10 days in the management of mild and moderate-SARS-CoV-2 infections in the US.

18 Jan 2023

Probiotic diminishes S. aureus bacterial colonization, Phase 2 trial shows

A promising approach to control Staphylococcus aureus bacterial colonization in people - using a probiotic instead of antibiotics - was safe and highly effective in a Phase 2 clinical trial.

17 Jan 2023

Study finds no difference in the survival benefit of two diuretics for heart failure patients

Two drugs widely used to treat adults with heart failure – furosemide and torsemide – showed no difference in their ability to improve patient survival when compared, according to findings from a clinical trial supported by the National Institutes of Health.

17 Jan 2023

Simple nasal spray effective at easing sleep-disordered breathing in children

A simple nasal spray significantly reduced snoring and breathing difficulties in children and halved the number needing to have their tonsils removed, according to a new study.

17 Jan 2023

Brain-computer interfaces' safety is similar to other implanted neurologic devices, study shows

For people with paralysis caused by neurologic injury or disease - such as ALS (also known as Lou Gehrig's disease), stroke, or spinal cord injury - brain-computer interfaces (BCIs) have the potential to restore communication, mobility, and independence by transmitting information directly from the brain to a computer or other assistive technology.

16 Jan 2023

Clinical Trial News and Research

Study reviews mechanistic data on new methods of allergy prevention and treatment

New research evaluates clinical trials investigating post-acute COVID-19 syndrome treatment

What was the prevalence of adverse events following first and second dose COVID-19 vaccinations in England?

Using motion capture technology and AI to monitor the progression of movement disorders

Scientists reveal why common anti-depressants cause emotional ‘blunting’ in users

Phase I trial results from AdaptVac's COVID capsid virus-like particle vaccine

Four-drug chemotherapy regimen provides longer overall survival for metastatic pancreatic ductal adenocarcinoma

Addition of nab-paclitaxel to gemcitabine/cisplatin does not improve overall survival of patients with advanced biliary tract cancers

Researchers create the first 'living medicine' to treat drug-resistant lung infections

Team-oriented approach improves the risk of acquiring post-procedural acute kidney injury

Vaccinated women well protected against severe COVID-19 symptoms, complications during pregnancy

New scan reliably detects primary aldosteronism, a common cause of hypertension

Group-based CBT relieves psychological distress, improves quality of life in younger heart patients

Investigational vaccine regimen safe but did not provide protection against HIV acquisition

What does the future of clinical trials and evidence-based medicine look like?

The efficacy of low-dose fluvoxamine compared with placebo for treating mild to moderate COVID-19 in the US

Probiotic diminishes S. aureus bacterial colonization, Phase 2 trial shows

Study finds no difference in the survival benefit of two diuretics for heart failure patients

Simple nasal spray effective at easing sleep-disordered breathing in children

Brain-computer interfaces' safety is similar to other implanted neurologic devices, study shows

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