Preclinical News and Research

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Proteins in the eye may be potential source for cost-effective test to predict Alzheimer's disease

Low levels of amyloid-β and tau proteins, biomarkers of Alzheimer's disease, in eye fluid were significantly associated with low cognitive scores, according to a new study published in the Journal of Alzheimer's Disease.

19 Mar 2019

Preclinical data shows combination immunotherapy could suppress tumor growth in the liver

Even as overall cancer incidence and mortality decrease in the United States, the number of people diagnosed with liver cancer is on the rise.

14 Mar 2019

Antibody-drug conjugate effectively targets surface protein in childhood neuroblastomas

Physician-scientists in the Cancer Center at Children's Hospital of Philadelphia have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing cancer cells.

14 Mar 2019

Harmless purple bacteria can visualize aspects of tumor heterogeneity

Cancer presents an ongoing challenge for physicians, particularly in the diagnosis and treatment of the disease. This is, amongst other things, due to tumor heterogeneity.

14 Mar 2019

New, quantitative method for assessment of molecular biomarker for osteoarthritis

For the first time, scientists at Wake Forest Baptist Medical Center have been able to measure a specific molecule indicative of osteoarthritis and a number of other inflammatory diseases using a newly developed technology.

13 Mar 2019

“Fail Fast, But More Confidently”: Developing Organoids for Drug Development and Discovery

Richard Eglen discusses the use of organoids in drug discovery, including the screening of candidate compounds for efficacy, toxicity, and pharmacokinetics.

From Corning Life Sciences 13 Mar 2019

Cancer imaging technique can help detect preeclampsia in pregnancy

An imaging technique used to detect some forms of cancer can also help detect preeclampsia in pregnancy before it becomes a life-threatening condition, a new Tulane study says.

13 Mar 2019

Study unravels how cancer medication works in brains of Parkinson's patients

Laboratory analysis from the first arm of a phase II clinical trial testing the use of nilotinib in patients with Parkinson's disease demonstrates precisely how the agent increases levels of dopamine in the brains of study participants, says a research team at Georgetown University Medical Center. Symptoms of Parkinson's, such as motor dysfunction, are a result of a dopamine loss.

13 Mar 2019

Parkinson's disease: Servier and Oncodesign announce research and drug development partnership

Servier and Oncodesign have announced a strategic partnership for the research and development of potential drug candidates for Parkinson's disease.

12 Mar 2019

Brain stimulation reduces depression symptoms, shows study

With a weak alternating electrical current sent through electrodes attached to the scalp, UNC School of Medicine researchers successfully targeted a naturally occurring electrical pattern in a specific part of the brain and markedly improved depression symptoms in about 70 percent of participants in a clinical study.

12 Mar 2019

Researchers find how common oral bacteria accelerates growth of colon cancer

Researchers at the Columbia University College of Dental Medicine have determined how F. nucleatum -- a common oral bacteria often implicated in tooth decay -- accelerates the growth of colon cancer. The study was published online in the journal EMBO Reports.

4 Mar 2019

Lipid-filled particle plays role in immune function and metabolism

Researchers have discovered that fat tissue releases a lipid-filled particle that has a role in immune function and metabolism. The study, in mice, was published online in the journal Science.

1 Mar 2019

MR Solutions to showcase latest multi-modality MRI systems at EMIM 2019

MR Solutions’ latest compact preclinical, multi-modality MRI systems will be on display at the 14th European Molecular Imaging Meeting (EMIM 2019) being held at the Scottish Event Campus in Glasgow on 19 to 22 March, 2019.

From MR Solutions 28 Feb 2019

Researchers are developing and testing novel gene therapy to cure Crigler-Najjar syndrome

Crigler-Najjar syndrome affects about one in a million people at birth. Because of a defective gene, these individuals lack an essential enzyme in their liver to eliminate bilirubin, a toxic bile pigment that accumulates in all body tissues causing jaundice and potentially leading to irreversible and lethal neurological damage.

28 Feb 2019

Existing drug for rare kidney disease could benefit patients with mitochondrial disorders

New preclinical findings from extensive cell and animal studies suggest that a drug already used for a rare kidney disease could benefit patients with some mitochondrial disorders--complex conditions with severe energy deficiency for which no proven effective treatments exist.

27 Feb 2019

Key to treat deadly cancers could lie deep within complex machinery of human cell

Buried deep within the dazzlingly intricate machinery of the human cell could lie a key to treating a range of deadly cancers, according to a team of scientists at Florida State University.

27 Feb 2019

Study findings can help develop new drugs for ischemia

Russian scientists investigated the role of opioid receptors in protecting the heart from coronary disease: the lack of its blood supply.

25 Feb 2019

Mitochondrial proteotoxicity appears to be epicentre of molecular pathogenesis

Researchers at the University of Helsinki uncovered the mechanisms for a novel cellular stress response arising from the toxicity of newly synthesized proteins.

22 Feb 2019

Innovative compound offers a new therapeutic approach to treat multiple sclerosis

Multiple sclerosis is an autoimmune disease that affects more than 2.3 million people worldwide. This debilitating condition periodically shutters communication between the brain and other parts of the body, resulting in symptoms that range from numbness and tingling in the arms and legs to blindness and paralysis.

22 Feb 2019

Sustained smoking cessation can lower risk of seropositive RA

Smoking is an important risk factor for developing the most common form of rheumatoid arthritis and other inflammatory diseases, but a critical question remains: Can those who quit smoking delay or prevent RA or have they permanently and irrevocably altered their risk of the disease? A new study by investigators from Brigham and Women's Hospital leverages data from the Nurses' Health Studies to find out.

21 Feb 2019

Preclinical News and Research

Proteins in the eye may be potential source for cost-effective test to predict Alzheimer's disease

Preclinical data shows combination immunotherapy could suppress tumor growth in the liver

Antibody-drug conjugate effectively targets surface protein in childhood neuroblastomas

Harmless purple bacteria can visualize aspects of tumor heterogeneity

New, quantitative method for assessment of molecular biomarker for osteoarthritis

“Fail Fast, But More Confidently”: Developing Organoids for Drug Development and Discovery

Cancer imaging technique can help detect preeclampsia in pregnancy

Study unravels how cancer medication works in brains of Parkinson's patients

Parkinson's disease: Servier and Oncodesign announce research and drug development partnership

Brain stimulation reduces depression symptoms, shows study

Researchers find how common oral bacteria accelerates growth of colon cancer

Lipid-filled particle plays role in immune function and metabolism

MR Solutions to showcase latest multi-modality MRI systems at EMIM 2019

Researchers are developing and testing novel gene therapy to cure Crigler-Najjar syndrome

Existing drug for rare kidney disease could benefit patients with mitochondrial disorders

Key to treat deadly cancers could lie deep within complex machinery of human cell

Study findings can help develop new drugs for ischemia

Mitochondrial proteotoxicity appears to be epicentre of molecular pathogenesis

Innovative compound offers a new therapeutic approach to treat multiple sclerosis

Sustained smoking cessation can lower risk of seropositive RA

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