Exhaustion News and Research

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Lactate may have a previously unrecognized role in fighting cancer

A new study by UT Southwestern's Simmons Cancer Center scientists suggests that lactate, a metabolic byproduct produced by cells during strenuous exercise, can rejuvenate immune cells that fight cancer.

6 Sep 2022

Immune cells beyond CAR-T cells affect the durability of response to BCMA CAR T therapy in myeloma

Patients with myeloma whose tumor immune microenvironments had a more diverse baseline T-cell repertoire, fewer markers of immune cell exhaustion, and distinct changes to immune cell populations were more likely to have longer progression-free survival (PFS) after treatment with BCMA-targeted T-cell therapy.

30 Aug 2022

New advice aims to reduce the cardiac side effects of cancer treatment

The first European Society of Cardiology Guideline on cardio-oncology is published online today in European Heart Journal.

26 Aug 2022

Researchers provide comprehensive review of human monkeypox infections

In a new study, researchers reviewed the various aspects of human monkeypox infections.

19 Aug 2022

ER physician shows how empathy, creativity, and imagination are the cornerstones of clinical care

To be an emergency room doctor is to be a professional listener to stories. Each patient presents a story; finding the heart of that story is the doctor's most critical task. More technology, more tests, and more data won't work if doctors get the story wrong.

16 Aug 2022

Researchers develop wearable technology to measure key brain mechanisms through the skin

Researchers at NYU Tandon have reached a key milestone in their quest to develop wearable technology that manages to measure key brain mechanisms through the skin.

9 Aug 2022

Terminally exhausted T cells may remain competent for transcription, researchers say

During a battle with cancer, T cells can become exhausted and are no longer able to function properly. The early phase of exhaustion can sometimes be reversed with immunotherapy drugs, but once T cells become too exhausted, it had been thought that this state was irreversible. However, new insights from University of Pittsburgh and UPMC researchers suggest that even the most fatigued T cells can be revived.

8 Aug 2022

Children are less fit and more obese than ever before, study says

Record levels of obesity and physical inactivity among children mean they are set to bear the brunt of poorer health effects from rising global temperatures – that's the stark warning in a new comprehensive review of current studies on the topic.

5 Aug 2022

‘Children are not little adults’ and need special protection during heat waves

After more than a week of record-breaking temperatures across much of the country, public health experts are cautioning that children are more susceptible to heat illness than adults are — even more so when they're on the athletic field, living without air conditioning, or waiting in a parked car.

4 Aug 2022

The aging human brain

Researchers describe alterations at the molecular and cellular levels that underly brain aging in otherwise healthy elderly adults.

3 Aug 2022

Study highlights impaired ketogenesis as a potential confounder of severe COVID-19

In severe Covid-19 patients, the metabolism produces insufficient amounts of certain energy-rich compounds called ketone bodies. However, these energy carriers are needed by two important cell types in the immune system in order to fight the virus effectively.

28 Jul 2022

How prepared are we for a widespread monkeypox outbreak?

In a new study, researchers summarized the epidemiology, etiology, clinical presentation, diagnosis and prevention and treatment strategies for monkeypox (MPX) caused by the monkeypox virus (MPXV).

25 Jul 2022

Scientists explore COVID-19-associated pulmonary aspergillosis

Researchers computationally investigated the causes of coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA).

25 Jul 2022

Can COVID-19 vaccination cause menstrual bleeding changes?

A recent study examined changes in menstrual bleeding following vaccination against SARS-CoV-2 among ethnically and gender-diverse pre-and postmenopausal women.

20 Jul 2022

Analyzing whether SARS-CoV-2 nucleocapsid and spike proteins stimulate dendritic or γδ T cells

Researchers showed that the SARS-CoV-2 nucleocapsid (N) and spike (S) proteins did not activate γδ T cells and dendritic cells (DCs).

18 Jul 2022

Survey explores the experiences of individuals with long COVID

Researchers explored the experiences of individuals with post-acute sequelae of COVID-19, also known as long COVID.

18 Jul 2022

As Big Pharma loses interest in new antibiotics, infections are only growing stronger

Forget covid-19, monkeypox, and other viruses for the moment and consider another threat troubling infectious disease specialists: common urinary tract infections, or UTIs, that lead to emergency room visits and even hospitalizations because of the failure of oral antibiotics.

15 Jul 2022