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Defective ASTN1 gene linked to developmental delay and neurological disorders

Nearly 30 years ago, researchers began studying the gene Astn1, which encodes the cell adhesion protein astrotactin 1 in mice, and its role in brain development.

10 Feb 2026

Researchers uncover mechanisms of three mismatch repair deficient high-grade glioma subtypes

Researchers have uncovered the mechanisms behind three unique subtypes of mismatch repair deficient high-grade gliomas.

10 Feb 2026

New spatial omics platform advances biomedical research in Spain

Spatial omics is a new generation of technologies that allow scientists to study cells in their original location within tissues (without isolating or moving them from their environment).

9 Feb 2026

Influenza viruses can directly impair heart function

Mount Sinai researchers have identified a cellular mechanism linking infections from influenza A viruses (IAVs) to cardiovascular disease, providing critical insights on how influenza can damage the heart and increase the risk of a heart attack or other major cardiovascular event.

9 Feb 2026

Study reveals DNA methylation score that better detects alcohol intake than standard biomarkers

A Mediterranean cohort study evaluated a DNA methylation biomarker of alcohol intake and compared it with conventional indicators such as GGT. The epigenomic score correlated with alcohol exposure, linked to telomere shortening and epigenetic aging markers, but findings remain observational and population-specific.

9 Feb 2026

Cholesterol transporter ABCA1 boosts macrophage-driven cancer immunity

In recent years, cancer researchers have made major breakthroughs by using the body's immune system to fight cancer. One of the most promising approaches, known as immune checkpoint blockade, works by releasing molecular "brakes" on T cells.

7 Feb 2026

New analysis reveals hidden complexity in the vaginal microbiome

For decades, gynecological tests have relied on a simplified view of the vaginal microbiome, categorizing bacteria as either "good" or "bad."

6 Feb 2026

Rapid malaria resistance evolution in Sudanese Coptic populations

The study published in PNAS sets out how, in just 1,500 years, the Copts have acquired a genetic variant that protects them from contracting malaria after mixing with other Sudanese populations.

6 Feb 2026

Computational method clarifies microbial signals in tumor sequencing

When scientists sequence tumor DNA, they typically find small amounts of genetic code from bacteria, viruses and fungi – microorganisms that, if actually present in tumor tissues, could influence how they grow, evade immunity or respond to treatment.

5 Feb 2026

New workflow boosts nuclear delivery for safer gene therapy

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus.

5 Feb 2026

Next-generation sequencing expands possibilities for newborn screening

Every year, millions of newborns undergo routine screening as a preventive strategy to detect inherited disorders before symptoms emerge.

4 Feb 2026

Five mutation patterns shape how cancers evade immunity

Cancer cells carry thousands of mutations, but not all mutations are created equal. Some make tumors highly visible to the immune system, while others help cancers hide.

4 Feb 2026

Burn injuries may have driven key human evolutionary traits

Humans' exposure to high temperature burn injuries may have played an important role in our evolutionary development, shaping how our bodies heal, fight infection, and sometimes fail under extreme injury, according to new research.

4 Feb 2026

Ohio faces Lyme disease risk comparable to endemic regions

The risk for being bitten by a tick infected with bacteria that cause Lyme disease is as high in Ohio as it is for those living in Northeast states that have dealt with Lyme disease for over 50 years, according to a new study.

3 Feb 2026

Six years after COVID-19: Lessons learned and pandemic preparedness

Six years ago, the Director-General of the World Health Organization sounded the highest global alarm available under international law at the time, declaring the outbreak of a new coronavirus disease (later known as COVID-19) a Public Health Emergency of International Concern (PHEIC).

3 Feb 2026

New liquid biopsy detects early cancers through epigenetic instability

Researchers at the Johns Hopkins Kimmel Cancer Center have developed a novel liquid biopsy approach to identify early-stage cancers by measuring the random variation in DNA methylation patterns, rather than the absolute level of those patterns as in other liquid biopsies.

2 Feb 2026

Oxybutynin shows promise in managing hot flashes for prostate cancer patients

A national clinical trial led by the Alliance for Clinical Trials in Oncology has found that oxybutynin, a drug often used to treat overactive bladder symptoms, reduces hot flashes compared to the placebo in men receiving hormone therapy for prostate cancer.

2 Feb 2026

Overlooked animal viruses slipping past global disease surveillance

The study on Influenza D and Canine Coronavirus HuPn-2018 underscores urgent needs for targeted surveillance and diagnostics in infectious disease research.

2 Feb 2026

Genetic ancestry influences tumor biology and survival in head and neck cancers

Genetic ancestry plays a key role in determining the behavior of head and neck tumors and may help explain why African-American patients survive for half as long as their counterparts of European ancestry, according to a new review study led by researchers from the University of Maryland School of Medicine's (UMSOM) Institute for Genome Sciences (IGS) and the University of Maryland Greenebaum Comprehensive Cancer Center (UMGCCC).

31 Jan 2026

New diagnostic framework addresses challenges of rapidly-mutating RNA viruses

The rapid evolutionary dynamics of RNA viruses, driven by high mutation rates and the consequent formation of complex quasispecies populations, present a formidable obstacle to conventional molecular diagnostic approaches.

30 Jan 2026