Histology News and Research

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Measuring the activity of a mouse brain from a single snapshot

Drs Nicolas Renier and Zhuhao Wu are post-doctoral fellows in the laboratory of Marc Tessier-Lavigne, Carson Family Professor and head of the Laboratory of Brain Development and Repair and President of Rockefeller University in New York. Over recent years, they have co-developed methodologies for new imaging techniques applying light sheet microscopy. Their latest work shows the study of neuronal activity in intact brains.

12 Oct 2016

Study identifies prognostic value of IDH and CIC mutations for grade II/III glioma patients

NRG Oncology investigators have identified two biomarkers that are prognostic of overall and progression-free survival for patients with lower-grade gliomas.

4 Oct 2016

SRS reduces likelihood of local recurrence of brain metastases in cancer patients

Stereotactic radiosurgery (SRS) for cancer patients who receive the treatment for brain metastases decreases the likelihood of local recurrence but shows no positive difference in terms of overall survival (OS) or distant brain metastases (DBMs) rates, when compared to observation alone following surgical resection of brain metastases, according to research presented today at the 58th Annual Meeting of the American Society for Radiation Oncology.

26 Sep 2016

microDimensions to host two compact digital pathology webinars on 11 October, 2016

microDimensions is hosting two compact digital pathology webinars back to back on Oct 11th.

From microDimensions - Bramlage Scientific GmbH 23 Sep 2016

Sanford wins $11.7 million NIH grant to translate laboratory cancer research into clinical trials

The Cancer Biology Research Center at Sanford Research is the recipient of a five-year, nearly $11.7 million grant from the National Institutes of Health to translate laboratory research into clinical trials for head and neck and pediatric cancers.

20 Sep 2016

Advances in brain research since patient HM: an interview with Dr Jacopo Annese

Jacopo Annese, President and CEO of the Institute for Brain and Society, discusses his work on the Human Brain Library.

From Huron Technologies 25 Aug 2016

Added benefit of lung cancer drug not proven, says IQWiG

Afatinib (trade name: Giotrif) has been approved since April 2016 for the treatment of adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) of squamous histology who have already received chemotherapy.

19 Aug 2016

Sleep-disordered breathing promotes progression of pediatric NAFLD to NASH

Studies have shown that obstructive sleep apnea and low nighttime oxygen, which result in oxidative stress, are associated with the progression of non-alcoholic fatty liver disease (NAFLD) in adults.

5 Aug 2016

First-line nivolumab promising in advanced NSCLC

Phase I results published in the Journal of Clinical Oncology suggest that nivolumab, either given alone or alongside platinum-based doublet chemotherapy, could have a role in the first-line treatment of advanced non-small-cell lung cancer.

5 Jul 2016

Pioglitazone effective in diabetes patients with NASH

Pioglitazone may halt the progression of nonalcoholic steatohepatitis in patients with prediabetes or Type 2 diabetes, a randomised trial shows.

28 Jun 2016

Adjuvant chemotherapy use benefits early-stage NSCLC patients

The use of adjuvant chemotherapy in early-stage non-small cell lung cancer (NSCLC) patients improves overall survival (OS) and 5-year OS in patients with tumor sizes ranging from 3 - 7 cm.

14 Jun 2016

Using Spectral Imaging to Study Brain Tumors in 3D

I’m a biophysicist at the University of Bordeaux and I mainly work on bio-imaging methods in the cancer laboratory research facility, mostly for brain cancers.

From Daylight Solutions Inc 13 Jun 2016

Advances in precision diagnostics aid accurate detection of CNS tumors

Thanks to new methods of precision diagnostics, such as DNA sequencing and epigenetic analyses, it is becoming increasingly possible to identify specific central nervous system (CNS) tumors accurately and to provide targeted treatment. The Comprehensive Cancer Center of MedUni Vienna and Vienna General Hospital is one of the top centers in the world for diagnosing and treating this type of tumor.

6 Jun 2016

Multiple cell and gene therapies can enhance cardiac function in mice modeled with MI

Researchers at the University of Utah compared the therapeutic potential of umbilical cord-derived sub-epithelial cells (UC-SECs), bone marrow-derived mesenchymal stem cells (BM-MSCs) and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) -- all derived from human tissue -- along with genes (S100a1 and SDF-1a) and growth factor (VEGF165) to evaluate how injected biologics might enhance cardiac function in mice modeled with myocardial infarction (MI; commonly referred to as heart attack).

2 Jun 2016

LaVison BioTec highlights Nicolas Renier's research on use of UltraMicroscope to study axon rewiring in nervous systems

LaVison BioTec, developers of advanced microscopy solutions for the life sciences, report on the work of Nicolas Renier, a Post-Doctoral Fellow in the laboratory of Marc Tessier-Lavigne at the Rockefeller University in New York where he applies light sheet microscopy to study axon rewiring in adult nervous systems.

12 May 2016

Fast image registration technology patent granted in the US

microDimensions announced today that the United States Patent and Trademark Office has issued the US Patent 2015/0016703 A1 for its method for image registration of sections, in particular of histological sections. The patented technology enables fast and accurate alignment of whole slide and other large images up to the scanned resolution.

From microDimensions - Bramlage Scientific GmbH 10 May 2016

Moffitt study reports that liver metastases have different sensitivities to radiation therapy

Radiation is a commonly used therapeutic option to treat liver metastases, with the majority of tumors maintained under control after one year. However, some patients do not respond as well to radiation treatment, and the factors that predict patient outcomes are unclear. Moffitt Cancer Center researchers report that liver metastases have different sensitivities to radiation therapy based on the location of the primary tumor.

13 Apr 2016

Radiation therapy plus PCV chemotherapy improves survival of low-grade glioma patients

Patients with a low-grade type of brain tumor called glioma who received radiation therapy plus a chemotherapy regimen, including procarbazine, lomustine and vincristine (PCV), experienced a longer progression-free survival and overall survival than patients who received radiation therapy alone, according to the results of the clinical trial, Radiation Therapy Oncology Group 9802 published in the April 7 issue of the New England Journal of Medicine.

7 Apr 2016

Study shows how Down Syndrome gene associated with altered oscillations in the cerebral cortex

Cerebral activity is governed by a fine balance between neuronal excitation and inhibition. Specifically, neurons are activated by excitation mechanisms tightly regulated by inhibition processes. For certain functions, the neuronal network needs to be synchronized.

6 Apr 2016

Novartis announces FDA approval of Afinitor for progressive, nonfunctional neuroendocrine tumors of GI

Novartis today announced that the United States Food and Drug Administration approved Afinitor (everolimus) tablets for the treatment of adult patients with progressive, well-differentiated, nonfunctional neuroendocrine tumors (NET) of gastrointestinal (GI) or lung origin that are unresectable, locally advanced or metastatic.

26 Feb 2016