Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Dietary adjustments may help control prostate cancer in men undergoing active surveillance

A new study led by UCLA Health Jonsson Comprehensive Cancer Center investigators offers new evidence that dietary changes may help reduce cancer cell growth in patients undergoing active surveillance, a treatment approach that involves regular monitoring of the cancer without immediate intervention.

14 Dec 2024

Machine learning model predicts CDK4/6 inhibitor effectiveness in metastatic breast cancer

A machine learning (ML) model incorporating both clinical and genomic factors outperformed models based solely on either clinical or genomic data in predicting which patients with hormone receptor (HR)-positive, HER2-negative metastatic breast cancer would have better outcomes from adding CDK4/6 inhibitors to endocrine therapy as first-line treatment, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.

14 Dec 2024

AI revolutionizes cancer research with advanced tools

Significant advancements in understanding the molecular and cellular mechanisms of tumor progression have been made, yet challenges remain.

13 Dec 2024

Metastatic breast cancer rates surge across U.S. women, exposing disparities and pandemic impacts

Metastatic breast cancer diagnoses are rising in U.S. women, especially in younger age groups and racial minorities, as revealed by SEER data from 2004–2021. The study highlights disparities and COVID-19's impact, urging systemic changes to improve early detection and healthcare equity.

12 Dec 2024

Exosomes: A double-edged sword in hepatocellular carcinoma

The TIME is a dynamic network composed of cancer cells, immune cells, and stromal components. During the early stages of tumorigenesis, the TIME attempts to eliminate abnormal cells through immune surveillance.

11 Dec 2024

Study provides the first evidence of genetic predisposition to breast cancer metastasis

Ninety percent of cancer deaths are due to the spread of cancer, not complications from the original tumor.

9 Dec 2024

Bacterial toxin may fuel colorectal cancer metastasis

A toxin in the bacteria that's one of the most common causes of foodborne illness accelerates the spread of colorectal tumors to other parts of the body, a study led by UF Health Cancer Center researchers and international collaborators has found.

6 Dec 2024

Extracellular vesicle DNA regulates immune responses and suppresses liver metastasis

The study highlights how EV-DNA packaging influences immune responses and its promise as a biomarker for assessing colorectal cancer metastasis risk.

6 Dec 2024

New insights into survival of breast cancer cells in the bone marrow

A study from researchers at the University of Michigan and the University of California San Diego has shed light on a previously poorly understood aspect of breast cancer recurrence: how cancer cells survive in bone marrow despite targeted therapies.

4 Dec 2024

Tumor secreted DNA triggers immune response against liver metastasis Special...

Specially packaged DNA secreted by tumor cells can trigger an immune response that inhibits the metastatic spread of the tumor to the liver, according to a study led by researchers at Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and Korea's Yonsei University.

4 Dec 2024

Novel single-cell genomics analysis approach provides direct insights into cell cycle and proliferation

By inferring proliferation rates from single-cell genomics, SPRINTER enhances understanding of tumor evolution and identifies key clones in cancer progression.

4 Dec 2024

Study shows lasting benefits of anti-hormonal therapy in postmenopausal women

Today, women with estrogen-sensitive breast cancer receive anti-hormonal therapy. Researchers now show that postmenopausal women with low-risk tumors have a long-term benefit for at least 20 years, while the benefit was more short-term for younger women with similar tumor characteristics who had not yet gone through the menopause.

3 Dec 2024

Phase 1 study finds serine- and glycine-free diet boosts immune response in colorectal cancer

Findings indicate a serine/glycine-free diet can reduce colorectal cancer growth and enhance immune response, offering insights for immunotherapy strategies.

29 Nov 2024

STAG2 loss linked to increased aggression in Ewing sarcoma

Ewing sarcoma is a tumor of the bones and soft tissues that occurs in children and young people. Like all childhood cancers, it is rare – 9 to 10 cases per million inhabitants per year – but it is very aggressive. 25% of patients do not respond well to regular therapy and they often experience relapses.

29 Nov 2024

Targeting intracellular checkpoints to enhance NK cell immunotherapy

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

27 Nov 2024

Researchers discover key protein interaction driving skin cancer growth

LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer.

22 Nov 2024

AI-designed drug ISM5939 granted IND clearance for cancer clinical trials

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announced that it has received IND clearance from FDA for ISM5939, a potential best-in-class oral small molecule inhibitor targeting ENPP1 for the treatment of solid tumors.

22 Nov 2024

Metastasis News and Research

Further Reading

Dietary adjustments may help control prostate cancer in men undergoing active surveillance

Machine learning model predicts CDK4/6 inhibitor effectiveness in metastatic breast cancer

AI revolutionizes cancer research with advanced tools

Metastatic breast cancer rates surge across U.S. women, exposing disparities and pandemic impacts

Exosomes: A double-edged sword in hepatocellular carcinoma

Study provides the first evidence of genetic predisposition to breast cancer metastasis

Bacterial toxin may fuel colorectal cancer metastasis

Extracellular vesicle DNA regulates immune responses and suppresses liver metastasis

New insights into survival of breast cancer cells in the bone marrow

Tumor secreted DNA triggers immune response against liver metastasis Special...

Novel single-cell genomics analysis approach provides direct insights into cell cycle and proliferation

Study shows lasting benefits of anti-hormonal therapy in postmenopausal women

Phase 1 study finds serine- and glycine-free diet boosts immune response in colorectal cancer

STAG2 loss linked to increased aggression in Ewing sarcoma

Targeting intracellular checkpoints to enhance NK cell immunotherapy

Researchers discover key protein interaction driving skin cancer growth

AI-designed drug ISM5939 granted IND clearance for cancer clinical trials

Small brain-penetrating molecule offers hope for treating aggressive brain tumors

Deep learning AI model outperforms humans in identifying pathologies

Innovative urine test could improve pancreatic cancer survival rates

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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