Oxidative Stress News and Research

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Oxidative Stress is a condition in which antioxidant levels are lower than normal. Antioxidant levels are usually measured in blood plasma.

Mitochondrial metabolite glutathione plays key role in breast cancer metastasis

The mitochondria may be the powerhouse of the cell, but mounting evidence suggests this organelle is also a driving force behind cancer.

18 Aug 2025

Targeting mitochondrial biogenesis to improve outcomes in acute kidney injury

Acute kidney injury (AKI) remains a significant global health challenge, with high mortality rates and the potential for progression to chronic kidney disease.

18 Aug 2025

New therapies for acute kidney injury show promise

Acute kidney injury (AKI) is a severe renal disorder affecting approximately 10%-15% of hospitalized patients and up to 50% in intensive care units (ICUs). Its pathogenesis involves complex inflammatory regulatory mechanisms. As core components of the cytokine network, interleukins (ILs) exert pleiotropic effects in AKI development, extensively participating in inflammation, fibrosis, tissue injury repair, and remote organ damage.

18 Aug 2025

Can ginger help diabetes? Major review says yes, it lowers blood sugar and inflammation effectively

A new systematic review of five meta-analyses confirms that ginger significantly reduces inflammation, lowers blood sugar and HbA1c in type 2 diabetes, and improves antioxidant status. It also effectively reduces nausea in pregnancy, though its impact on vomiting is less consistent.

17 Aug 2025

Eating over 60g of almonds a day may protect DNA and cut oxidative damage

A meta-analysis of eight clinical trials found that almond supplementation, especially at doses above 60 g/day, significantly reduced oxidative DNA and lipid damage and improved antioxidant enzyme activity in adults. The benefits varied by biomarker and were influenced by dose, preparation, and participant characteristics.

14 Aug 2025

Systems biology identifies sentinel biomarkers bridging ankylosing spondylitis and myocardial infarction

Ankylosing spondylitis (AS) is increasingly recognized as an independent risk factor for premature myocardial infarction (MI), yet the molecular bridge linking chronic axial inflammation to acute coronary events remains poorly mapped.

14 Aug 2025

Targeting ferroptosis to eliminate therapy-resistant cancer stem cells

Recent advancements in cancer research are shedding light on a novel therapeutic strategy aimed at overcoming the formidable challenge of cancer stem cells (CSCs).

14 Aug 2025

Prenatal acetaminophen linked to higher risk of autism and ADHD

Researchers at the Icahn School of Medicine at Mount Sinai have found that prenatal exposure to acetaminophen may increase the risk of neurodevelopmental disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD), in children.

14 Aug 2025

Curcumin activates SIRT3 to protect bone structure in diabetic mice

In a new Scientific Reports study, curcumin protected bone-forming cells from high-glucose damage by activating the SIRT3/FoxO3a/NRF2 antioxidant pathway and restoring mitochondrial health. In diabetic mice, curcumin improved bone density and oxidative balance, highlighting its potential in osteoporosis prevention.

13 Aug 2025

New compound shows promise against aromatase inhibitor-resistant breast cancer

A new research paper was published in Volume 16 of Oncotarget on July 29, 2025, titled "PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion."

13 Aug 2025

Study investigates aging-related mechanisms in idiopathic pulmonary fibrosis using AI approaches

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized by the excessive accumulation of extracellular matrix components, leading to a gradual decline in lung function and, ultimately, respiratory failure.

13 Aug 2025

Light-activated therapy boosts effectiveness of antifungal drugs against Candida albicans

Researchers at the Optics and Photonics Research Center (CePOF) have succeeded in increasing the susceptibility of the fungus Candida albicans to drug treatment through light-activated therapy.

12 Aug 2025

Nudibranchs (sea slugs) emerge as a promising source of cancer drugs

Researchers reviewed the antitumor potential of bioactive compounds from nudibranchs, marine mollusks that acquire or synthesize potent chemical defenses. These compounds, often sourced from their diet, show promising cancer-fighting activity through mechanisms like DNA damage, oxidative stress, and apoptosis.

12 Aug 2025

Polyphenols and exercise show promise in fighting gliomas

A new review in Food Science & Nutrition highlights how combining dietary polyphenols with structured exercise can enhance brain function, regulate epigenetics, and support glioma management. The authors outline mechanisms, patient-centered strategies, and research gaps for turning this synergy into clinical practice.

12 Aug 2025

Understanding the multifactorial causes of spina bifida

Spina bifida is among the most common and debilitating neural tube defects, affecting approximately 1 in every 2,875 newborns in the United States.

11 Aug 2025

Lauric acid could be a key cancer-fighting compound in coconut oil

Virgin coconut oil and lauric acid show promise in inhibiting cancer cell growth and mitigating chemotherapy toxicity, paving the way for future therapies.

11 Aug 2025

Gut bacteria may connect pregnancy diet to childhood autism

Unhealthy maternal diets may alter gut microbes, impacting brain development and increasing autism risk in offspring. Study the microbiome's influence.

8 Aug 2025

Scientists link brain lithium loss to early Alzheimer’s changes

Researchers have discovered that naturally occurring lithium in the brain is depleted early in Alzheimer’s disease, especially in the prefrontal cortex, and that restoring physiological levels with lithium orotate in mice can prevent brain damage and memory loss. The findings suggest lithium deficiency may be a modifiable risk factor for Alzheimer’s.

7 Aug 2025