Clinical Trial News and Research

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Parents represent a promising resource in preventing HIV among gay and bisexual male youth

A first of a kind study published today suggests that parents can be taught to communicate with their gay or bisexual sons about safe sex.

10 Nov 2022

Men and women respond similarly and positively to heart failure treatment with dapagliflozin

When it comes to heart failure (HF), sex differences are known to impact everything from risk factors to clinical presentation to response to treatment, making sex a key factor to consider in studies of emerging pharmacotherapies.

9 Nov 2022

Duke scientists join team involved in the first use of fetal therapy for Pompe disease

Experts at Duke Health were among a multi-national team involved in treating a fetus for infantile-onset Pompe disease using an enzyme replacement therapy - a first in the world.

9 Nov 2022

Neurotechnology shows potential for future medical interventions in humans

Neurotechnology - the combination of neuroscience and technology - has the potential to both "decode" and shape brain activity, with important implications for future interventions in humans.

9 Nov 2022

AI-powered system can predict healing of venous leg ulcers

A thermal-imaging tool to screen for chronic wounds could enable nurses to identify these hard-to-heal sores during the first assessment at a person's home.

9 Nov 2022

New program leverages digital solutions to improve patients' blood pressure and cholesterol levels

Heart disease is the leading cause of death in the United States and around the world. Lowering high blood pressure and cholesterol could help to reduce morbidity and mortality, but frequent in-person visits to measure and manage these readouts can be a burden for patients.

9 Nov 2022

MHRA grants approval for second Pfizer/Biontech bivalent Covid-19 booster vaccine

Approval has today been granted by the Medicines and Healthcare products Regulatory Agency (MHRA) for a Pfizer/BioNTech 'bivalent' Covid vaccine that targets both the Original strain of SARS-CoV-2 and the Omicron BA.4 and BA.5 sub-variants.

9 Nov 2022

Does fenofibrate improve clinical outcomes in patients with COVID-19?

Researchers assessed the effect of fenofibrate on acute COVID-19.

9 Nov 2022

Study: Fenofibrate not a useful strategy for decreasing COVID-19 severity

After showing promise in early laboratory research, the cholesterol-lowering drug fenofibrate had no significant effect on COVID-19 outcomes in a multicenter international randomized clinical trial led by Penn Medicine scientists.

8 Nov 2022

Mindfulness may offer a novel way to improve blood pressure control

A customized mindfulness program that taught participants to apply those skills to have healthy relationships with their diet, physical activity, alcohol use, medication adherence and stress, led to notably lower systolic (top number) blood pressure measures six months after participating in the mindfulness program, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2022.

7 Nov 2022

Administering steroids during heart surgery does not improve post-operative outcomes in infants

The largest clinical trial ever conducted in infants younger than age 1 undergoing heart surgery with cardiopulmonary bypass found that administering steroids during surgery did not improve post-operative outcomes compared to placebo, according to preliminary late-breaking research to be presented at the American Heart Association's Scientific Sessions 2022.

7 Nov 2022

Early use of ECMO devices to support adults with cardiogenic shock did not improve clinical outcomes

The immediate use of veno-arterial mechanical circulatory extracorporeal membrane oxygenation (ECMO) devices to support adults with rapidly deteriorating or severe cardiogenic shock was feasible but did not improve clinical outcomes compared to people who received early conservative therapy, according to late-breaking clinical trial results presented today at the American Heart Association's Scientific Sessions 2022.

7 Nov 2022

National study sheds light on how to more effectively treat atrial fibrillation

A national study led by UBC researchers at the Centre for Cardiovascular Innovation is shedding light on how to more effectively treat atrial fibrillation (AF) – a common heart rhythm problem associated with increased risk of stroke and heart failure.

7 Nov 2022

Rosuvastatin vastly superior to six common heart health supplements

Six widely used dietary supplements often advertised to promote heart health are actually ineffective at lowering cholesterol levels.

7 Nov 2022

Study reveals the extent of aggression towards caregivers in Parkinson's disease

Caregivers already dealing with the stress of looking after a loved one diagnosed with Parkinson's disease often have another concern to contend with - aggressive behavior directed toward them from the Parkinson's patient.

7 Nov 2022

Open bypass surgery results in better outcomes for specific patients with severe form of peripheral artery disease

Performing open bypass surgery to restore circulation for people with a severe form of peripheral artery disease (PAD) – a condition that limits blood flow to the legs and feet – resulted in better outcomes for specific patients compared to a less-invasive procedure, a National Institutes of Health-supported clinical research trial has found.

7 Nov 2022

Psilocybin could be a promising therapeutic strategy for people with treatment-resistant depression

Researchers at Trinity College Dublin have participated in the largest and most rigorous clinical trial to date of psilocybin (a psychoactive ingredient in magic mushrooms), pointing to the possibility that COMP360 psilocybin with psychological support could be a beneficial therapeutic strategy for people with treatment-resistant depression (TRD).

7 Nov 2022

Early head-and-neck cooling after sports concussion results in shorter time to return-to-play

Early head-and-neck cooling in concussed ice hockey players resulted in shorter time to return-to-play. This expanded study of Swedish ice hockey teams, in which the median time to initiate head-neck cooling following a concussion was 10 minutes, is published in the peer-reviewed Journal of Neurotrauma.

7 Nov 2022

New risk analysis strategy benefits chest pain patients compared to the usual testing approach

A study comparing two approaches for diagnosing heart disease found that a risk analysis strategy is superior to the usual approach of immediately performing functional tests or catheterization for low- to intermediate-risk patients with new-onset chest pain.

6 Nov 2022

Novel drug lowers triglycerides, does not reduce cardiovascular events

Levels of triglycerides are routinely measured as part of a preventive cardiology work-up and lowering triglycerides with several classes of drugs is common medical practice.

6 Nov 2022

Clinical Trial News and Research

Parents represent a promising resource in preventing HIV among gay and bisexual male youth

Men and women respond similarly and positively to heart failure treatment with dapagliflozin

Duke scientists join team involved in the first use of fetal therapy for Pompe disease

Neurotechnology shows potential for future medical interventions in humans

AI-powered system can predict healing of venous leg ulcers

New program leverages digital solutions to improve patients' blood pressure and cholesterol levels

MHRA grants approval for second Pfizer/Biontech bivalent Covid-19 booster vaccine

Does fenofibrate improve clinical outcomes in patients with COVID-19?

Study: Fenofibrate not a useful strategy for decreasing COVID-19 severity

Mindfulness may offer a novel way to improve blood pressure control

Administering steroids during heart surgery does not improve post-operative outcomes in infants

Early use of ECMO devices to support adults with cardiogenic shock did not improve clinical outcomes

National study sheds light on how to more effectively treat atrial fibrillation

Rosuvastatin vastly superior to six common heart health supplements

Study reveals the extent of aggression towards caregivers in Parkinson's disease

Open bypass surgery results in better outcomes for specific patients with severe form of peripheral artery disease

Psilocybin could be a promising therapeutic strategy for people with treatment-resistant depression

Early head-and-neck cooling after sports concussion results in shorter time to return-to-play

New risk analysis strategy benefits chest pain patients compared to the usual testing approach

Novel drug lowers triglycerides, does not reduce cardiovascular events

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