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New tool will help identify the most promising protein molecules for drug development

A cutting-edge digital tool that will make it cheaper, safer and faster for pharmaceutical companies to predict protein stability - a vital step in the development of new medicines - is being rolled out by scientists from the UK's University of Bath through their spin-out company, BLOC Labs.

28 May 2021

New microbial genes responsible for bile acid conversion is a major step forward for gut health

As the owner of a human body, you're carrying trillions of microbes with you everywhere you go. These microscopic organisms aren't just hitching a ride; many of them perform essential chemical reactions that regulate everything from our digestion to our immune system to our moods.

27 May 2021

Melatonin prevents kidney damage caused by metabolic complications of obesity

Scientists from the University of Granada (UGR), the Hospital Universitario La Paz (Madrid), and the University of Texas (USA) have taken an important step in the fight against kidney damage and its progression towards kidney failure, which is closely related to diabesity (obesity and its type 2 diabetes) and its complications.

27 May 2021

New favipiravir derivative is a potent SARS-CoV-2 inhibitor

In a new study recently published in Chemical Papers by Dr. Amgad Rabie (May 16th, 2021), a high potency derivative of favipiravir towards SARS-CoV-2 is engineered and investigated.

27 May 2021

Oligo DNA improves differentiation of skeletal muscles exacerbated by diabetes

Skeletal muscle is the largest organ in the body that accounts for 30 to 40% of body weight and is responsible for multiple functions such as energy metabolism and heat production.

27 May 2021

Light-controlled on/off switch helps control biological clock in cultured cells, explanted tissue

The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally.

27 May 2021

Researchers identify structure of agent that causes Alzheimer's and Parkinson's diseases

Alzheimer's disease - also called dementia - where memory and cognitive functions gradually decline due to deformation and death of neurons, and Parkinson's disease that causes tremors in hands and arms impeding normal movement are major neurodegenerative diseases.

26 May 2021

Could GRP78 be a therapeutic target against COVID-19?

A new study by a team of researchers at the Keck School of Medicine, University of Southern California, USA, reports a potentially important therapeutic target in the form of a molecule called GRP78 that promotes the entry and protein production by many viruses. The team's paper has been published in the Journal of Biological Chemistry.

26 May 2021

Researchers synthesize potential drugs with anti-cancer effects

New effective compounds, which can be endogenous donors of a signaling molecule - hydrogen sulfide in the body, were synthesized by SUSU scientists. Due to this property, the obtained compounds are potential drugs with a cancer-preventing effect.

26 May 2021

Scientists propose new strategies to find drugs that neutralize critical enzymes

Scientists from the University of Bath explore racemases and propose strategies for finding drugs that target these important enzymes.

26 May 2021

NFCR announces winners of 2021 Salisbury Award Competition

The National Foundation for Cancer Research (NFCR) announced winners of the 2021 Salisbury Award Competition for Entrepreneurial Translational Research, selected from among eight semi-finalists after pitch presentations in front of a judging committee consisting of prominent cancer research scientists, clinicians, early-stage investors and business leaders.

26 May 2021

Human T cells can target more than 1,400 sites on SARS-CoV-2 virus

In a new paper, scientists from La Jolla Institute for Immunology (LJI) bring together research findings from COVID-19 researchers around the world.

25 May 2021

New study may pave way for novel therapeutic strategies for COVID-19

An international and multidisciplinary team led by researchers at the University of Oxford, University of Glasgow, and University of Heidelberg, has uncovered the interactions that SARS-CoV-2 RNA establishes with the host cell, many of which are fundamental for infection.

25 May 2021

Newly identified small molecule can be used to rejuvenate the brain, counteract memory loss

Alzheimer's disease is the main cause of dementia and current therapeutic strategies cannot prevent, slow down or cure the pathology.

25 May 2021

Next-generation SARS-CoV-2 subunit vaccine candidate elicits powerful immunity in preclinical trials

New research – by scientists at the University of Chicago, Johns Hopkins School of Medicine and the University of Iowa in the USA – describes a novel COVID-19 vaccine candidate that has achieved impressive immunologic results in mouse studies.

25 May 2021

New technique using "soft" X-rays offers a simpler way to gain insight into nanocarriers

Before the huge potential of tiny nanocarriers for highly targeted drug delivery and environmental clean-up can be realized, scientists first need to be able to see them.

25 May 2021

The potential therapeutic value of CDK6 inhibitors in critical COVID-19

While drug repurposing has been explored in the context of the current coronavirus disease 2019 (COVID-19) pandemic, the success of this strategy has been limited so far. A new study, released as a preprint on the medRxiv* server, describes a new method of identifying a promising hit among drugs already in use.

24 May 2021

Novel natural compounds may help treat COVID-19, study suggests

A new study in the journal Chemistry Europe reports two natural compounds identified by virtual screening and computational modeling as having great promise for the development of drugs against SARS-CoV-2.

24 May 2021

STING agonist diABZI shows promise against SARS-CoV-2 variants

COVID-19 vaccines are the most effective way to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. For people who are already infected, new research suggests the small molecule stimulator of interferon genes (STING) agonist-1, diABZI, may be effective in controlling SARS-CoV-2 infection — including those caused by variants.

23 May 2021

Computationally designed peptide blocks the entry of SARS-CoV, SARS-CoV-2, and MERS-CoV

In order to develop effective antiviral drugs, scientists design active molecules based on their structures that can prevent or disrupt the specific viral-receptor binding - this is an effective strategy to prevent the virus from entering the host.

23 May 2021

Molecule News and Research

New tool will help identify the most promising protein molecules for drug development

New microbial genes responsible for bile acid conversion is a major step forward for gut health

Melatonin prevents kidney damage caused by metabolic complications of obesity

New favipiravir derivative is a potent SARS-CoV-2 inhibitor

Oligo DNA improves differentiation of skeletal muscles exacerbated by diabetes

Light-controlled on/off switch helps control biological clock in cultured cells, explanted tissue

Researchers identify structure of agent that causes Alzheimer's and Parkinson's diseases

Could GRP78 be a therapeutic target against COVID-19?

Researchers synthesize potential drugs with anti-cancer effects

Scientists propose new strategies to find drugs that neutralize critical enzymes

NFCR announces winners of 2021 Salisbury Award Competition

Human T cells can target more than 1,400 sites on SARS-CoV-2 virus

New study may pave way for novel therapeutic strategies for COVID-19

Newly identified small molecule can be used to rejuvenate the brain, counteract memory loss

Next-generation SARS-CoV-2 subunit vaccine candidate elicits powerful immunity in preclinical trials

New technique using "soft" X-rays offers a simpler way to gain insight into nanocarriers

The potential therapeutic value of CDK6 inhibitors in critical COVID-19

Novel natural compounds may help treat COVID-19, study suggests

STING agonist diABZI shows promise against SARS-CoV-2 variants

Computationally designed peptide blocks the entry of SARS-CoV, SARS-CoV-2, and MERS-CoV

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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