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Some drug combinations may be more effective than others for schizophrenic patients

Patients with schizophrenia are often treated with more than one type of psychiatric medication, but a new study suggests that some combinations may be more effective than others.

21 Feb 2019

University of Dundee partners with Takeda to develop new treatments for tau pathology

The University of Dundee Drug Discovery Unit has announced a partnership with Takeda, Japan's largest pharmaceutical company, to develop possible new therapeutic treatments for tau pathology, an underlying feature in several forms of neurodegeneration, including Alzheimer's disease.

20 Feb 2019

Novel preclinical model mimics persistent interneuron loss seen in preterm infants

Research-clinicians at Children's National Health System have created a novel preclinical model that mimics the persistent interneuron loss seen in preterm human infants, identifying interneuron subtypes that could become future therapeutic targets to prevent or lessen neurodevelopmental risks, the team reports Jan. 31, 2019, in eNeuro.

20 Feb 2019

T-cells play key role in how the body fights follicular lymphoma

Healthy white blood cells, called "T-cells," play a crucial role in how the body fights follicular lymphoma. That's according to the results of a study led by Mayo Clinic hematologists Zhi Zhang Yang, M.D., and Stephen Ansell, M.D., Ph.D., that was published in Cell Reports.

20 Feb 2019

Study reveals how helper T cells support memory cells to function optimally

The immune system's killer T cells are crucial in fighting viral infections. A fraction of them, called 'memory cells', live on once infection is controlled in order to fight re-infection by the same virus. They are of great interest as the basis of T cell-based vaccination and immunotherapies.

20 Feb 2019

Study suggests new treatment strategy for deadly brain cancer

In a study of mice and human brain tumors researchers at the University of the Michigan, Ann Arbor, searched for new treatments by exploring the reasons why some patients with gliomas live remarkably longer than others.

19 Feb 2019

Combination of PARP inhibitor and immunotherapy results in tumor regression in SCLC mouse models

Researchers at The University of Texas MD Anderson Cancer Center have discovered that a combination of immune checkpoint blockade and targeted therapies that block normal DNA damage repair achieved significant tumor regression in mouse models of small cell lung cancer, suggesting a promising new approach for treating patients with this aggressive cancer.

18 Feb 2019

Columbia researchers unravel why some glioblastomas respond to immunotherapy

Columbia researchers have learned why some glioblastomas--the most common type of brain cancer--respond to immunotherapy. The findings could help identify patients who are most likely to benefit from treatment with immunotherapy drugs and lead to the development of more broadly effective treatments.

17 Feb 2019

MUSC researchers discover new mechanism for a class of anti-cancer drugs

Researchers at the Medical University of South Carolina reveal a novel binding site for a class of anti-cancer drugs known as E1 inhibitors. This finding could lead to the design of more efficient E1 inhibitors.

15 Feb 2019

Newly developed stem cell technologies show promise for treating PD patients

Cell replacement may play an increasing role in alleviating the motor symptoms of Parkinson's disease (PD) in future. Writing in a special supplement to the Journal of Parkinson's Disease, experts describe how newly developed stem cell technologies could be used to treat the disease and discuss the great promise, as well as the significant challenges, of stem cell treatment.

15 Feb 2019

New therapeutic molecules show promise in reversing memory loss related to depression, aging

New therapeutic molecules developed at Toronto's Centre for Addiction and Mental Health show promise in reversing the memory loss linked to depression and aging.

15 Feb 2019

Cannabis use among adolescents linked with increased risk of depression in adulthood

While there has been a lot of focus on the role of cannabis use in psychosis, there has been less attention on whether cannabis use is associated with an increased risk of common mental health disorders, such as depression and anxiety.

13 Feb 2019

VA pushing research, inventions into commercial markets to improve public health

The U.S. Department of Veterans Affairs announced on Monday a new effort to improve public health by pushing its research and inventions into commercial markets.

12 Feb 2019

Study reveals how exercise may protect against Alzheimer's disease

Athletes know a vigorous workout can release a flood of endorphins: "feel-good" hormones that boost mood. Now there's evidence that exercise produces another hormone that may improve memory and protect against Alzheimer's disease, according to a study co-led by Ottavio Arancio, MD, PhD, a researcher at Columbia University's Vagelos College of Physicians and Surgeons and Taub Institute for Research on Alzheimer's Disease and the Aging Brain.

11 Feb 2019

Therapy derived from parasitic worms helps protect against one of chemotherapy's side effects

A therapy derived from the eggs of parasitic worms helps to protect against one of chemotherapy's debilitating side effects by significantly downregulating major proinflammatory pathways and reducing inflammation, indicates the first transcriptome-wide profiling of the bladder during ifosfamide-induced hemorrhagic cystitis.

8 Feb 2019

New simulations offer insights on vital atomic-scale drug-cardiac cells interactions

To unravel the mysterious mechanisms of drug potency for the treatment of cardiac arrhythmias, a group of researchers at UC Davis have developed novel simulations that provide insights on vital atomic-scale drug-cardiac cells interactions.

8 Feb 2019

Compounds found in fish oil may prevent pregnancy complications, finds study

Compounds found in fish oil prevent pregnancy complications, including preterm birth, neonatal death, and stillbirth, in mice when the complications are caused by a common oral bacteria, according to research published today in the journal JCI Insight.

8 Feb 2019

Preclinical News and Research

Some drug combinations may be more effective than others for schizophrenic patients

University of Dundee partners with Takeda to develop new treatments for tau pathology

Novel preclinical model mimics persistent interneuron loss seen in preterm infants

T-cells play key role in how the body fights follicular lymphoma

Study reveals how helper T cells support memory cells to function optimally

Study suggests new treatment strategy for deadly brain cancer

Combination of PARP inhibitor and immunotherapy results in tumor regression in SCLC mouse models

Columbia researchers unravel why some glioblastomas respond to immunotherapy

MUSC researchers discover new mechanism for a class of anti-cancer drugs

Newly developed stem cell technologies show promise for treating PD patients

New therapeutic molecules show promise in reversing memory loss related to depression, aging

Cannabis use among adolescents linked with increased risk of depression in adulthood

VA pushing research, inventions into commercial markets to improve public health

Study reveals how exercise may protect against Alzheimer's disease

Therapy derived from parasitic worms helps protect against one of chemotherapy's side effects

New simulations offer insights on vital atomic-scale drug-cardiac cells interactions

Compounds found in fish oil may prevent pregnancy complications, finds study

Bruker launches new SKYSCAN 1273 benchtop 3D X-ray microscope

New breakthrough study can impact drug development and personalized medicine

Researchers move a step closer to developing new pneumonia vaccine

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