Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Idiopathic pulmonary fibrosis study points to survival as key endpoint in future actimmune studies

InterMune, Inc. today announced that CHEST, the journal of the American College of Chest Physicians, published an important analysis of variables that measure clinical outcomes in patients with idiopathic pulmonary fibrosis (IPF), a deadly and debilitating lung disease.

10 Jan 2005

Core promoter mutants of Hepatitis B Virus e Antigen associated with development of fulminant hepatitis and liver cancer

Scientists in Brown Medical School, Providence, USA, have found that core promoter mutants of Hepatitis B Virus e Antigen replicate at up to 10-fold higher levels in transfected human hepatoma cells than the wild-type virus.

9 Jan 2005

New hope for millions of patients suffering from liver damage (cirrhosis)

Millions of patients suffering from liver damage (cirrhosis) and failure may benefit from research by the Universities of Edinburgh and Southampton which may lead to new life-saving treatments. There is currently no cure for liver cirrhosis and a patient's only hope of survival is to receive a liver transplant.

5 Jan 2005

Patient safety measures work at children’s hospitals

In recent years, children's hospitals have joined in the national push to improve patient safety and avoid preventable problems. But it has been hard to measure progress, because of uncertainty about whether standard patient safety measurement tools apply to their patients, who are younger, smaller and on average sicker than those at other hospitals.

4 Jan 2005

£2.5 million to support further research into gene therapy for cystic fibrosis

The funding commitment was made in the Genetics White Paper, 'Our Inheritance, Our Future: Realising the potential of genetics in the NHS' and will help to ensure that those with cystic fibrosis benefit as soon as possible from the latest advances in genetic knowledge and technologies.

4 Jan 2005

Australia leads the way in new screening technology for babies

Australia is one of the first countries in the world to implement new screening technology across all States that will help detect an increased number of diseases in newborns.

21 Dec 2004

Researchers discover clues to cirrhosis

Researchers at the University of Essex have found new biochemical indicators of cirrhosis in blood plasma which could help detect the disease in its early stages.

20 Dec 2004

Trimming fat overcomes one of the major obstacles to drug design

Biochemists at Ohio State University and their colleagues have overcome one of the major obstacles to drug design, by trimming some of the fat from a molecular sponge that scientists use to study proteins.

8 Dec 2004

Resveratrol antioxidant found in red wine may benefit heart tissue

New research on rat heart cells suggests that a well-known antioxidant found in red wine, called resveratrol, may benefit heart tissue by limiting the effects of a condition called cardiac fibrosis.

8 Dec 2004

Transplanted bone marrow cells reduce liver fibrosis in mice

Transplanted bone marrow cells can reduce carbon tetrachloride-induced liver fibrosis in mice and significantly improve their survival rates, according to a new study

8 Dec 2004

Research shows that even bacteria don't put their eggs in one basket

Diversification helps reduce overall risk by putting your eggs in more than one basket and is a strategy that strengthens groups of all kinds -- from forests challenged with environmental stress to stock market portfolios in uncertain times. Findings from University of Iowa researchers show that even bacteria have learned this important lesson.

16 Nov 2004

Discovery of new compounds that may treat mucus build-up associated with cystic fibrosis

Preliminary studies show these compounds improve the flow of mucus through the respiratory tract, allowing airways to clear more quickly and efficiently.

14 Nov 2004

Caspase levels associated with liver injury

Caspase activity in the sera of patients with chronic hepatitis C infection (HCV) may be a more sensitive measure of liver injury than conventional surrogate markers like aminotransferases, according to a new study published in the November 2004 issue of Hepatology.

8 Nov 2004

Treatment to control gastroesophageal reflux disease in children found to be ineffective

According to a study published in the American Gastroenterological Association (AGA) journal Clinical Gastroenterology and Hepatology, more than 60 percent of the children who received surgical fundoplication to control gastroesophageal reflux disease (GERD) had recurring symptoms of the disease months following surgery.

4 Nov 2004

Possible treatment for the fatal lung disease idiopathic pulmonary fibrosis

They found that the anti-cancer drug imatinib mesylate — commercially known as Gleevec and produced by Novartis Pharmaceuticals — can target a gene critical to controlling the disease process. Previously, there had been no treatment and patients usually did not survive beyond three years of diagnosis. Now the treatment is undergoing clinical trials at Mayo Clinic.

2 Nov 2004

New approaches for the treatment of chronic hepatitis C

Data from two ongoing studies testing new approaches for the treatment of chronic hepatitis C was presented at the annual meeting of the American Association for the Study of Liver Diseases (AASLD) this afternoon.

1 Nov 2004

Genetic evidence to support an inherited tendency to retain salt

Researchers at the University of Chicago have found genetic evidence to support the sodium-retention hypothesis, a controversial 30-year-old theory that the high rate of hypertension in certain ethnic groups is caused, in part, by an inherited tendency to retain salt.

29 Oct 2004

Some people who chew betel nut may be genetically more prone to mouth cancer

The nut of the betel or areca palm tree contains a mild, central nervous system stimulant called arecoline. Chewing the nut on its own or with a mixture of tobacco, lime and betel leaf is a popular habit in Asian countries and among British Asians.

12 Oct 2004

Innovative help for parents of autistic children

In 1997, the Pennsylvania Department of Education held a focus group of parents with autistic children throughout the state to learn more about their needs. George Shadie of Luzerne County was one of those parents.

11 Oct 2004

A new study shows that sick children can go home from the hospital more quickly

A new study shows that sick children can go home from the hospital more quickly, less expensively and with less chance of a repeat visit if children's hospitals use a unique source of national data to check their performance against other children's hospitals and show them where they can improve.

5 Oct 2004