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Potential treatment strategies for patients suffering long-term COVID-19 symptoms

A new paper in Oxford Open Immunology, published by Oxford University Press, examines prior findings in the field of neuroimmunology that suggest potential treatment strategies for patients suffering long-term symptoms from COVID-19.

10 Feb 2021

Pancreatic β cells secrete miR-29 in response to high levels of free fatty acids

In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output.

9 Feb 2021

Higher blood pressure from childhood may put Black people at risk for congestive heart failure

Starting with early childhood, otherwise healthy Black people show signs of slightly diminished heart muscle strength and a slightly higher blood pressure than their white counterparts, factors which may put them on a course for early development of congestive heart failure, researchers report.

8 Feb 2021

Scientists find link between developmental coordination disorder risk and difficulties with time perception

Neuroscientists at McMaster University have found a link between children who are at risk for developmental coordination disorder (DCD), a common condition that can cause clumsiness, and difficulties with time perception such as interpreting changes in rhythmic beats.

7 Feb 2021

FDA permits marketing of new prescription only device to reduce snoring and mild sleep apnea

Today, the U.S. Food and Drug Administration authorized marketing of a new prescription only device intended to reduce snoring and mild obstructive sleep apnea.

5 Feb 2021

Study uncovers link between T cell-mediated inflammation and cardiac dysfunction

Inflammation is supposed to help protect us - it's part of an immune response to fight off pathogens and clear infections. But patients with cardiac disease often have chronic inflammation that damages their hearts, even with no infection present.

5 Feb 2021

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Senescent cells accumulate in organs during aging, promote tissue dysfunction, and cause numerous aging-related diseases like cancer. The cells arise through a process called "cellular senescence," a permanent cell cycle arrest resulting from multiple stresses.

5 Feb 2021

Greater muscle strength associated with lower risk of COVID-19 hospitalization

A new preprint research paper posted to the medRxiv* server discusses the results of a study exploring the relationship between increased muscle strength and hospitalization for severe COVID-19.

4 Feb 2021

Researchers call for trials of rapamycin to treat COVID-19

Researchers in the United States, China, and the UK have called for immediate large-scale clinical trials of an antibiotic called rapamycin as a prophylactic and treatment approach to coronavirus disease 2019 (COVID-19) in older individuals.

4 Feb 2021

Race may play an important role in children's food allergies

Black children have significantly higher rates of shellfish and fish allergies than White children, in addition to having higher odds of wheat allergy, suggesting that race may play an important role in how children are affected by food allergies, researchers at Ann & Robert H. Lurie Children's Hospital of Chicago, Rush University Medical Center and two other hospitals have found.

4 Feb 2021

Russia's Sputnik V COVID-19 shown to have 91.6 percent efficacy

The phase 3 human trial is the last stage of clinical evaluation, showing how effective and safe a drug or vaccine is. In this case, the Gam- Sputnik V showed a consistent strong protective effect across all participant age groups.

3 Feb 2021

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Pompe disease is a hereditary genetic disorder caused by a deficiency of acid alpha-glucosidase leading to build-up of glycogen in the lyosomes, which then causes cell damage in various tissues, in particular the heart, the muscles, the liver and the nervous system.

3 Feb 2021

Scientists unravel the workings of a mysterious protein implicated in movement disorders

Scientists at Scripps Research have clarified the workings of a mysterious protein called Gαo, which is one of the most abundant proteins in the brain and, when mutated, causes severe movement disorders.

3 Feb 2021

Study gives new clues to how muscle wasting occurs on a cellular level

Muscle wasting, or the loss of muscle tissue, is a common problem for people with cancer, but the precise mechanisms have long eluded doctors and scientists. Now, a new study led by Penn State researchers gives new clues to how muscle wasting happens on a cellular level.

3 Feb 2021

Intensity of physical training does not seem to matter during cancer treatment

People receiving treatment for cancer are known to feel better with physical training. But does it make any difference how vigorously they exercise?

3 Feb 2021

Study: Brain hormones could improve metabolism and fight obesity

A mitochondrial hormone expressed by cells deep in the brain appears to play a role in improving metabolism and fighting off obesity, according to a new study in mice.

3 Feb 2021

New process separates beneficial glucocorticoids from unwanted side-effects

A collaboration led by Scripps Research has developed a way to separate the beneficial anti-inflammatory properties of a group of steroids called glucocorticoids from some of their unwanted side-effects, through an optimization process they named "ligand class analysis."

3 Feb 2021

Previous SARS-CoV-2 infection may negate need for two vaccine doses

Researchers in the United States have shown that two doses of vaccine may not be necessary to protect against coronavirus disease 2019 (COVID-19) among people who have already been infected with the causative agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2 Feb 2021

Scientists discover potential drug target for Hutchinson-Gilford progeria syndrome

New study describes a potential drug target for Hutchinson-Gilford progeria syndrome that may aid in the development of more effective treatments.

2 Feb 2021

Lower diagnostic threshold for fever in older people may help detect COVID-19 cases earlier

Researchers have explored heritable factors, age and body mass on temperature variation between humans. One notable finding is that the current threshold for detecting fever in older adults may be too high, precluding the ability to detect COVID-19 early on

2 Feb 2021

Muscle News and Research

Potential treatment strategies for patients suffering long-term COVID-19 symptoms

Pancreatic β cells secrete miR-29 in response to high levels of free fatty acids

Higher blood pressure from childhood may put Black people at risk for congestive heart failure

Scientists find link between developmental coordination disorder risk and difficulties with time perception

FDA permits marketing of new prescription only device to reduce snoring and mild sleep apnea

Study uncovers link between T cell-mediated inflammation and cardiac dysfunction

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Greater muscle strength associated with lower risk of COVID-19 hospitalization

Researchers call for trials of rapamycin to treat COVID-19

Race may play an important role in children's food allergies

Russia's Sputnik V COVID-19 shown to have 91.6 percent efficacy

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Scientists unravel the workings of a mysterious protein implicated in movement disorders

Study gives new clues to how muscle wasting occurs on a cellular level

Intensity of physical training does not seem to matter during cancer treatment

Study: Brain hormones could improve metabolism and fight obesity

New process separates beneficial glucocorticoids from unwanted side-effects

Previous SARS-CoV-2 infection may negate need for two vaccine doses

Scientists discover potential drug target for Hutchinson-Gilford progeria syndrome

Lower diagnostic threshold for fever in older people may help detect COVID-19 cases earlier

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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