Preclinical News and Research

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Device uses light to treat overactive bladder

Researchers have developed an implantable device that could one day treat overactive bladder.

2 Jan 2019

Genetically diverse mouse models improves usability for precision medicine for Alzheimer's

Incorporating genetic diversity into a mouse model of Alzheimer's disease resulted in greater overlap with the genetic, molecular and clinical features of this pervasive human disease, according to a study funded by the National Institute on Aging, part of the National Institutes of Health.

28 Dec 2018

Researchers review applications, properties, and pharmacological potentials of rose hip

The genus Rosa from family Rosaceae is one of the most widespread species from the family. One species, rose hip, is known as a good source of different types of micronutrients and phytochemicals such as phenolic acids, tannins, and flavonoids. It is known as a traditional treatment in folk medicine.

28 Dec 2018

MUSC researchers link higher levels of AGEs to ER-positive breast cancer risk

Poor diet and lack of exercise are associated with cancer development, but the underlying biology is not well understood. Advanced glycation end products could offer a biological link to help us understand how certain lifestyle behaviors increase cancer risk or lessen the likelihood that an anti-cancer therapy will be effective.

28 Dec 2018

New review focuses on the structure-activity relationships of flavonoids

ABCB1 in the ABC transporter family also termed as P-glycoprotein, grants the simultaneous resistance of metastatic cancer cells towards various anti-cancer drugs with different targets and diverse chemical structures.

27 Dec 2018

Genetic testing can help personalize diagnosis and treatment of kidney disease, study shows

A new study has found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and identifying the responsible gene has a direct impact on treatment for most of these patients.

26 Dec 2018

Simple protocol rescues stressed liver cells

Isolated human hepatocytes are essential tools in preclinical and clinical liver research, but cell quality is highly variable. Now, researchers from Uppsala University have devised a simple protocol that improves hepatocyte quality and enables cells from a wider quality spectrum to be used in standard and advanced cell culture. The findings are published in Archives of Toxicology.

21 Dec 2018

Experts in Parkinson's research propose roadmap for drug trials targeting alpha-synuclein

A recently discovered protein, alpha-synuclein, has become one of the most attractive targets for developing new drugs with the potential to slow down or arrest the progression of Parkinson's disease

20 Dec 2018

Study finds how pyruvate helps improve cardiac output in pediatric patients with LCOS

Can pyruvate, the end product of glycolysis, help improve cardiovascular function in children who have cardiopulmonary bypass surgery and suffer from low cardiac output syndrome? This question is one that Rafael Jaimes, Ph.D., a staff scientist at Children's National Heart Institute, a division of Children's National Health System, is studying, thanks to a two-year grant from the American Heart Association.

19 Dec 2018

MUSC researchers identify potential therapeutic target for lung fibrosis

In an article published online by Frontiers in Endocrinology, researchers at the Medical University of South Carolina report that they have identified a potential therapeutic target for lung fibrosis or scarring.

19 Dec 2018

New therapy for childhood blindness shows 'very promising' results

A new therapy aimed at improving the sight of people with one of the most common forms of childhood blindness, has shown 'very promising' initial results, according to a study involving UCL researchers.

18 Dec 2018

Researchers identify link between mucus in the small airways and pulmonary fibrosis

A team of investigators led by members of the University of Colorado School of Medicine faculty at CU Anschutz Medical Campus has identified a connection between mucus in the small airways and pulmonary fibrosis.

18 Dec 2018

Research identifies nerve-signaling pathway behind sustained pain after injury

A toddler puts her hand on a hot stove and swiftly withdraws it. Alas, it's too late--the child's finger has sustained a minor burn. To soothe the pain, she puts the burned finger in her mouth.

13 Dec 2018

Study investigates attitudes toward implementation of 'sex as a biological variable' policy

In 2016, the National Institutes of Health implemented a policy which requires grant applicants to "consider sex as a biological variable" in vertebrate animal and human studies. A new study surveyed NIH study section members in 2016 and 2017 regarding their attitudes toward the policy and found that a majority of respondents thought that it was important to consider SABV in the experimental design and that considering SABV would improve the rigor and reproducibility of NIH-funded preclinical research.

13 Dec 2018

A positive uptake regarding new sex-inclusion policy in biomedical research

The good news: An increasing number of scientists are including female animals in their experimental designs and analyses for preclinical studies, as required by the National Institutes of Health (NIH) in January 2016, reports a new Northwestern Medicine study.

13 Dec 2018

Virginia Tech and UC San Diego researchers team up to develop nonopioid drug for chronic pain

Researchers from the Virginia Tech School of Neuroscience are teaming with the University of California San Diego and the U.S. National Institutes of Health to develop a drug -- now in its earliest stages -- that can treat certain types of chronic pain without the addictive consequences of opioids.

12 Dec 2018

New collaborative partnership in quest of novel antibiotics

The Global Antibiotic Research and Development Partnership, Eisai Co., Ltd. and Takeda Pharmaceutical Company Limited have signed an agreement for GARDP to access and screen components of Eisai and Takeda's chemical libraries.

12 Dec 2018

Integral Molecular and Merus collaborate to develop bispecific antibody therapeutics

Integral Molecular, the industry leader in the discovery of monoclonal antibodies against membrane proteins, and Merus N.V., a clinical-stage immuno-oncology company developing innovative bispecific antibody therapeutics, announced that they have entered into a collaboration on multiple undisclosed targets.

12 Dec 2018

Study could lead to a potential new way of treating sepsis

Australian emergency doctors are at the forefront of a large clinical study to assess how clinicians are treating sepsis.

11 Dec 2018

Ezogabine treatment reduces motor neuron excitability in ALS patients, study shows

Brian Wainger, MD, PhD, of the Healey Center for ALS at Massachusetts General Hospital presented initial, top-level results of a recently completed phase 2 clinical trial of ezogabine (also called retigabine) on December 9 at the Motor Neurone Disease Association annual meeting in Glasgow, Scotland.

11 Dec 2018

Preclinical News and Research

Device uses light to treat overactive bladder

Genetically diverse mouse models improves usability for precision medicine for Alzheimer's

Researchers review applications, properties, and pharmacological potentials of rose hip

MUSC researchers link higher levels of AGEs to ER-positive breast cancer risk

New review focuses on the structure-activity relationships of flavonoids

Genetic testing can help personalize diagnosis and treatment of kidney disease, study shows

Simple protocol rescues stressed liver cells

Experts in Parkinson's research propose roadmap for drug trials targeting alpha-synuclein

Study finds how pyruvate helps improve cardiac output in pediatric patients with LCOS

MUSC researchers identify potential therapeutic target for lung fibrosis

New therapy for childhood blindness shows 'very promising' results

Researchers identify link between mucus in the small airways and pulmonary fibrosis

Research identifies nerve-signaling pathway behind sustained pain after injury

Study investigates attitudes toward implementation of 'sex as a biological variable' policy

A positive uptake regarding new sex-inclusion policy in biomedical research

Virginia Tech and UC San Diego researchers team up to develop nonopioid drug for chronic pain

New collaborative partnership in quest of novel antibiotics

Integral Molecular and Merus collaborate to develop bispecific antibody therapeutics

Study could lead to a potential new way of treating sepsis

Ezogabine treatment reduces motor neuron excitability in ALS patients, study shows

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