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Common chemotherapy supplement weakens the pancreatic cancer's defenses in mice

The fight against cancer is an arms race, and one of the most effective weapons in clinicians' arsenals is immunotherapy. Immune checkpoint therapy has become the standard for treating several types of cancer.

27 Aug 2024

Public voices often ignored in states’ opioid settlement money decisions

The conversation wasn't sounding good for Kensington residents on June 20. The Philadelphia neighborhood is a critical center of the nation's opioid crisis, and the city had decided to spend $7.5 million in opioid settlement money to improve the quality of life there.

27 Aug 2024

New method uncovers hidden cancer targets

Fighting cancer effectively often involves stopping cancer cells from multiplying, which requires understanding the proteins that the cells rely on to survive.

27 Aug 2024

A novel approach to photosynthetic production of high-value compounds

Using evolution as a guiding principle, researchers have successfully engineered bacteria-yeast hybrids to perform photosynthetic carbon assimilation, generate cellular energy and support yeast growth without traditional carbon feedstocks like glucose or glycerol. By engineering photosynthetic cyanobacteria to live symbiotically inside yeast cells, the bacteria-yeast hybrids can produce important hydrocarbons, paving new biotechnical pathways to non-petroleum-based energy, other synthetic biology applications, and the experimental study of evolution.

27 Aug 2024

Study warns of high Medicare costs for semaglutide even with restrictive CVD definition

If Medicare Part D narrowly defines cardiovascular disease, the majority of patients would remain ineligible while new federal spending could still exceed $10 billion

27 Aug 2024

Stem cell study identifies unique glial contributions to multiple sclerosis

A team of scientists from The New York Stem Cell Foundation (NYSCF) Research Institute and Case Western Reserve University has created the largest reported collection of stem cell models from multiple sclerosis (MS) patients and used them to identify unique ways in which glia – integral support cells in the brain – contribute to the disease.

26 Aug 2024

Renewed interest in psychedelics as potential addiction therapies

After years of being seen as dangerous "party drugs," psychedelic substances are receiving renewed attention as therapies for addiction -- but far more research is needed, according to a new special series of articles in the Journal of Studies on Alcohol and Drugs, published at Rutgers University.

26 Aug 2024

University of Oklahoma researcher receives NIH grant to explore natural cancer treatments

Today, about 25% of drugs approved to treat cancer are derived from nature – from the bark of a tree to marine life to bacteria in the soil.

26 Aug 2024

GLP-1 therapy boosts visceral fat metabolism, driving weight loss

Researchers discuss the role of enhanced visceral adipose tissue metabolism in mediating weight loss by glucagon-like peptide-1 drugs.

26 Aug 2024

Clarification urgently needed for detected signal of semaglutide-linked suicidal ideation

Researchers investigate the potential link between the obesity drugs semaglutide and liraglutide and suicidal or self-injurious adverse drug reactions.

26 Aug 2024

GPePV neurons identified as key players in controlling cocaine addiction behaviors

Researchers examine how GPePV cells regulate cocaine-induced behaviors through interactions with ventral tegmental area dopamine cells.

25 Aug 2024

New method determines optimal timing for cancer treatment based on circadian rhythm

How effective medications are depends on various factors, including the time of day when they are administered.

23 Aug 2024

Strength training triggers key mechanisms for cellular waste clearance

The elimination of damaged cell components is essential for the maintenance of the body's tissues and organs.

23 Aug 2024

New $5.8 million grant aims to transform the global landscape of TB research

A $5.8 million grant led by Adrie Steyn, Ph.D., of the University of Alabama at Birmingham and the Africa Health Research Institute, or AHRI, in Durban, South Africa, will provide user-requested infected human lung tissue and analytical services to tuberculosis researchers worldwide.

23 Aug 2024

Cholinesterase inhibitors may slow cognitive decline in dementia with Lewy bodies

Dementia with Lewy bodies is a type of dementia that is similar to both Alzheimer's disease and Parkinson's disease but studies on long-term treatments are lacking.

23 Aug 2024

AI advances drug discovery for mental health disorders with new receptor models

Artificial intelligence (AI) can help identify molecules that could serve as new drugs for mental health disorders.

23 Aug 2024

Defective ZNRF3 gene causes opposing brain sizes and potential tumor risk

A gene called ZNRF3, known to be involved in cancer, also messes with the mind. The human brain relies on two copies of this gene to build a right-sized brain. If one of the copies is defective, the brain will be either too small or too large - known as mirror effect -, leading to various neurological symptoms.

23 Aug 2024

Memory cues may help reduce alcohol consumption, study finds

Researchers exploring the role memory plays in alcohol consumption believe it could help people drink less booze.

23 Aug 2024

Innovative drug reduces inflammation in rats by inhibiting neutrophil activation

A newly developed compound that reduces harmful inflammation in rats caused by overactive neutrophils shows great potential as a safer treatment for various inflammatory diseases in humans.

23 Aug 2024

Trump drastically inflates annual fentanyl death numbers

Former President Donald Trump claimed at a recent campaign rally that more than 300,000 Americans are dying each year from the synthetic opioid drug fentanyl, and that the number of fentanyl overdoses was the "lowest" during his administration and has skyrocketed since.

23 Aug 2024