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Research provides new insights on the architecture of yeast nuclear pore complex

Nuclear pore complexes (NPCs) are massive multi-protein complexes that act as passageways for the transport of molecules into and out of the nucleus.

3 Jan 2022

Alzheimer’s disease risk genes disturb the brain protective mechanism

The brain has a natural protective mechanism against Alzheimer's disease, and researchers at Baylor College of Medicine, Texas Children's Hospital and collaborating institutions have discovered that gene variants associated with risk of developing the disease disturb the protective mechanism in ways that can lead to neurodegeneration.

3 Jan 2022

SARS-CoV-2 Omicron study on hamsters, shows virus results in a less severe disease

Researchers investigate the ability of immunity acquired from SARS-CoV-2 wild-type infection to protect against the Omicron variant in Syrian hamster models.

3 Jan 2022

Study shows structural and functional aspects of antibody neutralization of SARS-CoV-2 Omicron variant

Researchers investigated the potency of trimeric human nephrocystin SH3, TriSb92, a domain-derived antibody, against a conserved region in the receptor-binding domain (RBD) of the spike protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.

31 Dec 2021

New technique combines bioprinting with cryopreservation to construct frozen structures

A new technique takes bioprinting - in which an ink of cells is printed, layer by layer, to form a structure - to a whole new, and icy level. Investigators from the Zhang lab at Brigham and Women's Hospital have developed a technology that they term "cryobioprinting," a method that uses a bioink embedded with cells to print frozen, complex structures that can be easily stored for later use.

31 Dec 2021

An integrated computational methodology for COVID drug prioritization

Researchers recently published a study in the journal Briefings in Bioinformatics wherein they integrated multiple bioinformatics and cheminformatics-based methods to prioritize drugs for the treatment of COVID-19.

29 Dec 2021

3-dose vaccines deemed ultrapotent against diverse and highly transmissible SARS-CoV-2 Omicron and other variants

A new study found that the presence of a subset of antibodies with broad neutralizing activities against all circulating variants of concern in the three-dose vaccines' memory B-derived antibody repertoire suggests that the Omicron/future variants infection may elicit selective and rapid recall of humoral responses, conferring secondary protection directed by memory etched in the immune system.

29 Dec 2021

Significant gaps found in nutrition-related care for patients with kidney disease

Dietary and nutritional changes are needed when patients develop kidney disease; however, new research published in CJASN reveals that in many countries, there are significant gaps in care related to the importance of nutrition for maintaining kidney health.

29 Dec 2021

Researchers investigate the effect of emerging SARS-CoV-2 mutations on ACE2 binding

Now in new research, scientists from the University of Leicester have been investigating how these mutations alter the affinities of RBDs to ACE2.

28 Dec 2021

Structural blueprint of nanoparticles developed to target neutrophils responsible for acute lung inflammation

The COVID-19 pandemic highlighted the devastating impact of acute lung inflammation (ALI), which is part of the acute respiratory distress syndrome (ARDS) that is the dominant cause of death in COVID-19.

28 Dec 2021

Researchers discover antibodies that neutralize omicron and other SARS-CoV-2 variants

An international team of scientists have identified antibodies that neutralize omicron and other SARS-CoV-2 variants. These antibodies target areas of the virus spike protein that remain essentially unchanged as the viruses mutate.

28 Dec 2021

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

Using a short, synthetic chain of chemically modified nucleotides engineered in the RNA Therapeutics Institute at UMass Chan Medical School, Robert H. Brown Jr., DPhil, MD, Jonathan Watts, PhD, and colleagues have shown the ability to suppress mutant forms of an ALS gene known as C9ORF72 in a single-patient pilot study.

24 Dec 2021

New study provides a mutational analysis of SARS-CoV-2

A new study investigates mutational waves in structural and non-structural protein evolutions of SARS-CoV-2 to better understand the virus’s evolution and epidemiology.

24 Dec 2021

Recently evolved region of the ‘dark genome’ provides clues to treatment of schizophrenia, bipolar disorder

Scientists investigating the DNA outside our genes - the 'dark genome' - have discovered recently evolved regions that code for proteins associated with schizophrenia and bipolar disorder.

23 Dec 2021

Omicron has enhanced infectivity that is only weakly neutralized by vaccination or prior infection

Scientists used virus-like particles and found that Omicron showed increased infectivity, relative to the B.1 and B.1.1 strains, which was similar to the Delta variant.

23 Dec 2021

New insights into how red meat-rich diet increases cardiovascular disease risk

A Cleveland Clinic-led study has revealed new insights into how a diet rich in red meat increases risk for cardiovascular disease. The findings were published in Nature Microbiology and build on more than a decade of research by lead author Stanley Hazen, MD, PhD.

23 Dec 2021

The transmission dynamics of SARS-CoV2 Omicron variant

In a recent study posted to the medRxiv* preprint server, researchers developed a coronavirus disease (COVID-19) model-inference system in South Africa to determine transmission dynamics and immune evasion associated with severe acute respiratory syndrome-associated coronavirus disease (SARS-CoV-2) Omicron variant.

22 Dec 2021

World leaders meet to discuss about COVID-19 vaccines, therapeutics and diagnostics

The heads of the International Monetary Fund, World Bank Group, World Health Organization and World Trade Organization held high-level consultations with Gavi and UNICEF on 17 December, 2021 aimed at increasing the use of COVID-19 vaccines and other critical medical countermeasures in low-income (LIC) and lower middle-income (LMIC) countries and supporting countries to be better prepared, resourced, and ready to roll out vaccines.

22 Dec 2021

Researchers receive NIH grants to develop new treatments for neglected tropical diseases

Researchers at Washington University School of Medicine in St. Louis have received two grants from the National Institutes of Health totaling more than $5.5 million to develop new treatments for two types of devastating parasitic infections common in sub-Saharan Africa and Central and South America: river blindness and intestinal worm infections.

22 Dec 2021

Scientists identify a panel of nanobodies with good neutralizing efficacy against SARS-CoV-2 variants of concern

A team of scientists from Canada has recently characterized a panel of nanobodies against the spike protein of SARS-CoV-2.

22 Dec 2021

Therapeutics News and Research

Research provides new insights on the architecture of yeast nuclear pore complex

Alzheimer’s disease risk genes disturb the brain protective mechanism

SARS-CoV-2 Omicron study on hamsters, shows virus results in a less severe disease

Study shows structural and functional aspects of antibody neutralization of SARS-CoV-2 Omicron variant

New technique combines bioprinting with cryopreservation to construct frozen structures

An integrated computational methodology for COVID drug prioritization

3-dose vaccines deemed ultrapotent against diverse and highly transmissible SARS-CoV-2 Omicron and other variants

Significant gaps found in nutrition-related care for patients with kidney disease

Researchers investigate the effect of emerging SARS-CoV-2 mutations on ACE2 binding

Structural blueprint of nanoparticles developed to target neutrophils responsible for acute lung inflammation

Researchers discover antibodies that neutralize omicron and other SARS-CoV-2 variants

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

New study provides a mutational analysis of SARS-CoV-2

Recently evolved region of the ‘dark genome’ provides clues to treatment of schizophrenia, bipolar disorder

Omicron has enhanced infectivity that is only weakly neutralized by vaccination or prior infection

New insights into how red meat-rich diet increases cardiovascular disease risk

The transmission dynamics of SARS-CoV2 Omicron variant

World leaders meet to discuss about COVID-19 vaccines, therapeutics and diagnostics

Researchers receive NIH grants to develop new treatments for neglected tropical diseases

Scientists identify a panel of nanobodies with good neutralizing efficacy against SARS-CoV-2 variants of concern

Event guide: The Non-Opioid Pain Therapeutics Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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