Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

New drug shows promise in driving insulin-producing beta cells to multiply

In a screen of more than 100,000 potential drugs, only one, harmine, drove human insulin-producing beta cells to multiply, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai, funded by JDRF and the National Institutes of Health, and published online today in Nature Medicine.

10 Mar 2015

Loyola's Genomics Facility uses next generation sequencing to study genetic make-up of organisms

Loyola University Chicago's Genomics Facility is using an advanced technology called next generation sequencing to assist a broad range of researchers studying the genetic make-up of organisms ranging from viruses to humans.

9 Mar 2015

1 in 5 of the UK population could be walking around with ‘ticking time bomb’

Kidney Research UK polled 2,000 adults across the UK to find out just how much people know about the disease. Startlingly, almost three quarters (74%) of those polled claim to have limited or no knowledge of kidney disease, its causes or its symptoms.

6 Mar 2015

Severe mortality-associated diseases less prevalent in members of long-lived families

Recent research from the Long Life Family Study (LLFS) confirms that severe mortality-associated diseases are less prevalent in the families of long-lived individuals than in the general population. The Journals of Gerontology, Series A will publish these findings in the article titled, "Are Members of Long-Lived Families Healthier than Their Equally Long-Lived Peers? Evidence from the Long Life Family Study" on March 5, 2015.

6 Mar 2015

Biomarker for compilation of Risk Score for non-alcoholic steatohepatitis

40 percent of people in the EU suffer from non-alcoholic steatohepatitis (fatty liver disease), a disease which is becoming increasingly more frequent as a result of diabetes and excess weight in an affluent society. Currently, it is not possible to forecast the further course of the disease - right up to cirrhosis and cancer of the liver. Furthermore, an increased risk of heart attack and kidney damage exists. In future, this should become possible using a Risk Score with different biomarkers.

6 Mar 2015

Mallinckrodt enters into definitive agreement to acquire Ikaria

Mallinckrodt plc, a leading global specialty biopharmaceutical company, and Ikaria, Inc. a privately-held critical care company, announced today that they have entered into a definitive agreement under which a subsidiary of Mallinckrodt will acquire Ikaria, Inc. from a Madison Dearborn-led investor group in a transaction valued at approximately $2.3 billion.

5 Mar 2015

New study assesses suicide risks in older, white males with advanced bladder cancer

Older, single white males with advanced bladder cancer have the highest suicide risk among those with other cancers of the male genitals and urinary system, researchers report.

5 Mar 2015

OTC medications, dietary and herbal supplements cause drug-induced acute liver failure

Drug-induced acute liver failure is uncommon, and over-the-counter medications and dietary and herbal supplements -- not prescription drugs -- are its most common causes, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

4 Mar 2015

New report: Prevalence of CKD in the U.S. projected to increase 16.7% by 2030

The prevalence of chronic kidney disease (CKD) will rise in the United States, according to a new report led by RTI International and published in the American Journal of Kidney Diseases during March's National Kidney Month.

3 Mar 2015

Teen-LABS study explores safety, health effects of surgical weight loss procedures

Cardiovascular risks of severe pediatric obesity, assessed among adolescents participating in the "Teen Longitudinal Assessment of Bariatric Surgery" (Teen-LABS) study, were published this week in JAMA Pediatrics. Teen-LABS is a multi-center clinical study funded by the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health that is examining the safety and health effects of surgical weight loss procedures.

3 Mar 2015

EMA's CHMP backs JINARC (tolvaptan) for autosomal dominant polycystic kidney disease

Otsuka Pharmaceutical Co., Ltd. announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has recommended JINARC (tolvaptan) for approval.

3 Mar 2015

Higher intake of lycopene may lower risk of renal cell carcinoma in postmenopausal women

A higher intake by postmenopausal women of the natural antioxidant lycopene, found in foods like tomatoes, watermelon and papaya, may lower the risk of renal cell carcinoma, a type of kidney cancer.

2 Mar 2015

U-M researchers reveal key role of two enzymes that help the body to remove cholesterol, other lipids

With the aid of X-ray crystallography, researchers at the University of Michigan have revealed the structures of two closely related enzymes that play essential roles in the body's ability to metabolize excess lipids, including cholesterol.

2 Mar 2015

Bionomics to present data from DisrupTOR-1 trial at ASCO Genitourinary Cancers Symposium

Bionomics Limited is to present important additional data from the DisrupTOR-1 trial of BNC105 in patients with metastatic renal cancer at the ASCO Genitourinary Cancers Symposium in Orlando, Florida. The data will be presented by Dr. Sumanta Pal of the City of Hope Comprehensive Cancer Center in California in his poster presentation.

28 Feb 2015

New medical device could revolutionise kidney disease care in the UK

A new medical device which combines nanotechnology with a pregnancy tester could help diagnose and treat the 1 million people in the UK who don’t know they have kidney disease, a new report by the Institution of Mechanical Engineers reveals today.

26 Feb 2015

Sorafenib, sunitinib provide no benefit to patients with locally advanced kidney cancer

Findings from a federally funded study suggest that patients with locally advanced kidney cancer should not be treated with either adjuvant (post-surgery) sorafenib or sunitinib. The average period to disease recurrence was similar between those who received sorafenib or sunitinib after surgery (5.6 years) and those treated with placebo (5.7 years).

25 Feb 2015

Accuray, Lancaster announces commercial availability of InCise MLC for CyberKnife M6 System

Accuray Incorporated and Lancaster General Health announced today that the first commercially available InCise Multileaf Collimator (MLC) for the CyberKnife M6 System has been received by Lancaster.

24 Feb 2015

Diets high in animal proteins can worsen progression of kidney disease

An estimated 26 million people in the United States have chronic kidney disease, which can lead to complete kidney failure. Once the kidneys fail, patients either need to undergo dialysis treatments three times a week or have a kidney transplant to remain alive.

24 Feb 2015

Two widely used targeted therapy drugs not effective in preventing return of kidney cancer

Two widely used targeted therapy drugs— approved by the FDA for use in metastatic kidney cancer —are no more effective than a placebo in preventing return of the disease to increase life spans of patients suffering from advanced kidney cancer after surgery, according to new results to be presented by a researcher at the University of Pennsylvania's Abramson Cancer Center during the 2015 Genitourinary Cancers Symposium.

24 Feb 2015

Study results report no benefit from use of sunitinib, sorafenib among patients with kidney cancer

Research results highlighted today at the press conference of a major medical meeting report no benefit from the use of either Sutent (sunitinib) or Nexavar (sorafenib) among patients with locally advanced renal cell carcinoma at high risk of recurrence, the ECOG-ACRIN Cancer Research Group announced.

24 Feb 2015

Nephrology News and Research

Further Reading

New drug shows promise in driving insulin-producing beta cells to multiply

Loyola's Genomics Facility uses next generation sequencing to study genetic make-up of organisms

1 in 5 of the UK population could be walking around with ‘ticking time bomb’

Severe mortality-associated diseases less prevalent in members of long-lived families

Biomarker for compilation of Risk Score for non-alcoholic steatohepatitis

Mallinckrodt enters into definitive agreement to acquire Ikaria

New study assesses suicide risks in older, white males with advanced bladder cancer

OTC medications, dietary and herbal supplements cause drug-induced acute liver failure

New report: Prevalence of CKD in the U.S. projected to increase 16.7% by 2030

Teen-LABS study explores safety, health effects of surgical weight loss procedures

EMA's CHMP backs JINARC (tolvaptan) for autosomal dominant polycystic kidney disease

Higher intake of lycopene may lower risk of renal cell carcinoma in postmenopausal women

U-M researchers reveal key role of two enzymes that help the body to remove cholesterol, other lipids

Bionomics to present data from DisrupTOR-1 trial at ASCO Genitourinary Cancers Symposium

New medical device could revolutionise kidney disease care in the UK

Sorafenib, sunitinib provide no benefit to patients with locally advanced kidney cancer

Accuray, Lancaster announces commercial availability of InCise MLC for CyberKnife M6 System

Diets high in animal proteins can worsen progression of kidney disease

Two widely used targeted therapy drugs not effective in preventing return of kidney cancer

Study results report no benefit from use of sunitinib, sorafenib among patients with kidney cancer

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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