Preclinical News and Research

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A new vaccine shows promise in protecting people from rabies, Lassa fever

A novel vaccine designed to protect people from both Lassa fever and rabies showed promise in preclinical testing, according to new research published in Nature Communications.

12 Oct 2018

DNA vaccine shown to provide long-term protection from Ebola

A synthetic DNA vaccine has been shown to provide complete and enduring protection from Ebola virus in preclinical studies.

11 Oct 2018

Columbia scientist and collaborators receive $11.3 million to find new targets against brain disease

Anthony Fitzpatrick, PhD, a Principal Investigator at Columbia's Zuckerman Institute and Columbia University Irving Medical Center, together with scientists from the Mayo Clinic and Boston Children's Hospital, has been awarded $11.3 million to map the three-dimensional structures of protein tangles that accumulate in the human brain.

11 Oct 2018

Otago scientists make a breakthrough in monkey malaria research

A breakthrough in monkey malaria research by University of Otago scientists encouraged the Bill & Melinda Gates Foundation to fund a special meeting in Dunedin recently.

11 Oct 2018

Phase 2 results on tazemetostat EZH2 inhibitor to be presented at ESMO 2018

Epizyme, Inc., a clinical-stage company developing novel epigenetic therapies, announced today that updated efficacy and safety data from the fully enrolled cohort of epithelioid sarcoma (ES) patients in its ongoing Phase 2 trial of tazemetostat will be presented in a poster discussion session at the European Society for Medical Oncology (ESMO) 2018 Congress to be held October 19-23 in Munich, Germany.

10 Oct 2018

Honey Analyses: Using NMR to Reduce Fraud

This interview with CEO of Sweetwater Labs, Jim Gawenis, explores the increasing importance of NMR in the detection of honey fraud.

From Bruker BioSpin Group 10 Oct 2018

Cleveland Clinic awarded $6 million NIH grant to study techniques used for ACL reconstruction

The National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health, has awarded Cleveland Clinic $6 million to study techniques used for anterior cruciate ligament reconstruction.

10 Oct 2018

Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage 3 melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early.

8 Oct 2018

NCCN adds COPIKTRA capsules to NCCN Guidelines for follicular lymphoma

Verastem, Inc., focused on developing and commercializing medicines to improve the survival and quality of life of cancer patients, today announced that the National Comprehensive Cancer Network added COPIKTRA (duvelisib) capsules to the Clinical Practice Guidelines in Oncology (NCCN Guidelines) for follicular lymphoma.

8 Oct 2018

Researchers show possibility to restore insulin cell function in type 2 diabetes

By blocking a protein, VDAC1, in the insulin-producing beta cells, it is possible to restore their normal function in case of type 2 diabetes. In preclinical experiments, the researchers behind a new study have also shown that it is possible to prevent the development of the disease.

8 Oct 2018

FDA and EMA accept Novartis' regulatory application for siponimod to treat SPMS in adults

Novartis today announced that both the US Food and Drug Administration and European Medicines Agency have accepted the company's New Drug Application and Marketing Authorization Application respectively, for investigational oral, once-daily siponimod (BAF312) for the treatment of secondary progressive multiple sclerosis in adults.

8 Oct 2018

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

A team of Medical University of South Carolina Hollings Cancer Center researchers received a three-year, $1.2 million grant from the U.S. Department of Defens to test a potential therapeutic antibody that could block breast cancer growth with fewer side effects, opening up potential for future drug development.

5 Oct 2018

Researchers identify sex-specific genetic risk factor for pancreatic cancer

In a new study from Lawson Health Research Institute and Western University's Schulich School of Medicine & Dentistry, researchers have found that mutation of a gene called ATRX may lead to increased risk of developing pancreatitis and pancreatic cancer in females.

5 Oct 2018

Study shows possibility of using PET imaging to manage chronic liver diseases

While liver biopsies are powerful and reliable, they are also invasive, painful, limited and subject to complications. These effects may soon be a thing of the past for some patients thanks to new research showing PET imaging with the 18F-FAC radiotracer can be used as a non-invasive substitute. The study is featured in the October issue of The Journal of Nuclear Medicine.

5 Oct 2018

MD Anderson and Cyclacel announce strategic alliance to evaluate novel drugs for hematological malignancies

The University of Texas MD Anderson Cancer Center and Cyclacel Pharmaceuticals, Inc., today announced a three-year strategic alliance agreement that will enable clinical evaluation for safety and efficacy of three Cyclacel medicines in patients with hematological malignancies, including chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and other advanced leukemias.

4 Oct 2018

Vaxart to present new data from Phase 2 Challenge Study of H1 influenza oral tablet vaccine

Vaxart, Inc., a clinical-stage biotechnology company developing oral recombinant vaccines that are administered by tablet rather than by injection, announced it will present new data from the Phase 2 Challenge Study of its H1 influenza oral tablet vaccine at IDWeek 2018 in San Francisco on Saturday, October 6, 2018.

4 Oct 2018

New ReFRAME drug repurposing collection offers hope for treating major diseases

Each year, millions of people worldwide suffer from potentially fatal infectious diseases that often leave survivors facing a lifetime of related health problems. But what if drugs against such diseases already existed but nobody knew it?

4 Oct 2018

Understanding immune system's balancing act could help in prevention, treatment of IBD

Australian researchers have uncovered clues in the immune system that reveal how the balance of 'good' gut bacteria is maintained. This information could help in the prevention and treatment of inflammatory bowel disease.

3 Oct 2018

Alnylam reports further progress on broadening the therapeutic potential of RNAi

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today further progress on the Company's platform efforts in extrahepatic delivery of novel siRNA conjugates, including central nervous system (CNS) and ocular delivery in rat and non-human primates (NHPs).

3 Oct 2018

HyFly research project aims to break chains of infection and prevent pandemics

Global air travel isn't restricted to people and goods - infectious agents, too, can make their way on board as unwelcome passengers and travel great distances within a matter of hours.

1 Oct 2018

Preclinical News and Research

A new vaccine shows promise in protecting people from rabies, Lassa fever

DNA vaccine shown to provide long-term protection from Ebola

Columbia scientist and collaborators receive $11.3 million to find new targets against brain disease

Otago scientists make a breakthrough in monkey malaria research

Phase 2 results on tazemetostat EZH2 inhibitor to be presented at ESMO 2018

Honey Analyses: Using NMR to Reduce Fraud

Cleveland Clinic awarded $6 million NIH grant to study techniques used for ACL reconstruction

Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

NCCN adds COPIKTRA capsules to NCCN Guidelines for follicular lymphoma

Researchers show possibility to restore insulin cell function in type 2 diabetes

FDA and EMA accept Novartis' regulatory application for siponimod to treat SPMS in adults

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

Researchers identify sex-specific genetic risk factor for pancreatic cancer

Study shows possibility of using PET imaging to manage chronic liver diseases

MD Anderson and Cyclacel announce strategic alliance to evaluate novel drugs for hematological malignancies

Vaxart to present new data from Phase 2 Challenge Study of H1 influenza oral tablet vaccine

New ReFRAME drug repurposing collection offers hope for treating major diseases

Understanding immune system's balancing act could help in prevention, treatment of IBD

Alnylam reports further progress on broadening the therapeutic potential of RNAi

HyFly research project aims to break chains of infection and prevent pandemics

Event guide: 4th LNP Formulation & Process Development Summit eBook

Latest eBooks

Editorial Focus eBook - Spatial and single-cell omics (1st edition)

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics