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University of Nottingham to lead £6.5m research project that aims to develop next generation biomaterials

The University of Nottingham is to lead a £6.5m research project which aims to make the leap from 2D to 3D in the development of advanced materials and realise the true potential of regenerative medicine and medical devices for the future.

27 Aug 2015

Transplanting multi-layered sheet of liver cells into damaged liver improves function in test animals

Liver transplantation is currently the only established treatment for patients with end stage liver failure. However, this treatment is limited by the shortage of donors and the conditional integrity and suitability of the available organs. Transplanting donor hepatocytes (liver cells) into the liver as an alternative to liver transplantation also has drawbacks as the rate of survival of primary hepatocytes is limited and often severe complications can result from the transplantation procedure.

27 Aug 2015

ASTRO awards $675,000 to seven physician-researchers to advance radiation oncology research

The American Society for Radiation Oncology has selected seven leading physician-researchers to receive a total of $675,000 in awards and grants to advance radiation oncology research. Together, the seven funding grants, including ASTRO Junior Faculty Career Research Training Award, the ASTRO Residents/Fellows in Radiation Oncology Research Seed Award and the ASTRO/Radiation Oncology Institute Comparative Effectiveness Research Award, will support studies in radiation and cancer biology, radiation physics, translational research, outcomes/health services research and comparative effectiveness research within radiation oncology.

27 Aug 2015

Researchers evaluate use of human fetal progenitor tenocyte to repair tendon injuries

Tendon injuries, especially those acquired while engaging in sports, are not easily healed due to the fibrous nature of tendon tissues which transmit forces from muscle to bone and protect surrounding tissues against tension and compression. Tendon injuries to wrists, knees, elbows and rotator cuffs, often from over use when playing golf or tennis, are increasingly common for both professional and amateur athletes ("weekend warriors") alike.

21 Aug 2015

Synthorx employs synthetic DNA technology to produce proteins containing novel amino acids

Synthorx Inc. announced today that the company has employed its proprietary protein expression system to successfully produce proteins containing novel amino acids. Using a semi-synthetic DNA template (containing the synthetic base pair X and Y), Synthorx scientists were able to produce RNA containing X and Y, which was used with an otherwise fully natural biological system, to efficiently direct the incorporation of multiple novel amino acids at different sites in proteins.

19 Aug 2015

Researchers test new non-invasive technique that can accurately detect malignant melanoma

Researchers have developed a new non-invasive technique which can accurately detect malignant melanoma without a biopsy.

18 Aug 2015

Putaminal serotonergic innervation flags levodopa-induced dyskinesia risk

Increased serotonergic fibre innervation relative to dopaminergic fibre availability may be a potential marker of disease progression in Parkinson’s disease patients and a possible warning of levodopa-induced dyskinesia, indicates an in vivo imaging study.

17 Aug 2015

GlySens secures FDA approval to extend current human clinical evaluation of fully implanted CGM system

GlySens Incorporated announced today that it has secured FDA approval for extending the current human clinical evaluation of its fully implantable continuous glucose monitoring system (the ICGM System) from the originally approved six-month duration to the system's commercially-intended operational duration of twelve months.

17 Aug 2015

Researchers reveal how migrating tumour cells produce protein that helps set up home in bones

Cancer cells that migrate to the bone acquire a unique trait: They start to express the protein cathepsin K. Researchers from the University of Freiburg and the BIOSS Centre for Biological Signalling Studies have now solved why it is important for the migrating cells to produce this protein.

17 Aug 2015

Nitrogen oxides affect pollen of common ragweed plant

Pollen of the common ragweed (Ambrosia artemisiifolia) has higher concentrations of allergen when the plant is exposed to NO2 exhaust gases, according to findings of scientists of Helmholtz Zentrum München. In addition, the study published in the journal 'Plant, Cell & Environment' indicates the presence of a possible new allergen in the plant.

17 Aug 2015

Centenary Institute researchers take lead on promising new class of drugs for melanoma treatment

Researchers at Sydney’s Centenary Institute have taken the lead on a promising new class of drugs that may prove to be highly effective for the treatment of certain cases of melanoma.

14 Aug 2015

New endoscopic system differentiates between malignant and benign tumors in gastrointestinal tract

Cancer or no cancer? This question can usually only be answered after a days-long wait for a histological examination. With the use of a mass spectrometric technique, the answer may soon be available in real time.

13 Aug 2015

Scientists reveal how non-allergenic pollen mediators can increase allergic reactions

Scientists at Helmholtz Zentrum München and TU München discovered a new mechanism how non-allergenic pollen mediators can enhance allergic reactions. Especially the so-called B cells play a critical role in this process. The results were recently published in the Journal 'Allergy' and might lead to new approaches for therapies.

13 Aug 2015

Researcher study potential biomarker to determine patients at risk for aggressive breast cancer

Biomarkers are an important part in detecting certain cancers such as the BRCA gene in breast cancer and the PSA antigen in prostate cancer. They are easy to identify in a blood test and can help in diagnosing and giving a prognosis.

12 Aug 2015

Embryonic stem cells may help researchers to study physiological effects of environmental pollutants on human health

A recent study published in the Journal of Environmental Sciences shows that embryonic stem cells could serve as a model to evaluate the physiological effects of environmental pollutants efficiently and cost-effectively.

11 Aug 2015

LA BioMed's Nagendra Mishra to be honored with 2015 ICAAC Young Investigator Award

Nagendra Mishra, PhD, a Los Angeles Biomedical Research Institute researcher will be honored by the American Society of Microbiology with a 2015 Interscience Conference of Antimicrobial Agents and Chemotherapy Young Investigator Award during the conference Sept. 17-21 in San Diego.

11 Aug 2015

Novel treatment target found for RV failure in PAH

Researchers have identified a molecular pathway by which downregulation of microRNA-126 contributes to right ventricular failure in patients with pulmonary arterial hypertension.

10 Aug 2015

Turing Pharmaceuticals acquires rights to market Daraprim (pyrimethamine) in the U.S.

Turing Pharmaceuticals AG today announced that it has acquired the exclusive rights to market Daraprim (pyrimethamine) in the U.S. from Impax Laboratories, Inc. The acquisition by Turing is part of a strategic effort focused on treatments for toxoplasmosis and other serious infectious diseases. The company also announced plans to invest in the development of new drug candidates for toxoplasmosis.

10 Aug 2015

Vascular side effects prevent first-line ponatinib use in chronic phase CML

Ponatinib is highly active when given to patients within 6 months of developing chronic phase chronic myeloid leukaemia, phase II results show, but its toxicity profile is unacceptable for first-line treatment.

7 Aug 2015

Study may lead to effective antimicrobial treatment strategies for people with uncontrolled diabetes

Case Western Reserve scientists may have uncovered a molecular mechanism that sets into motion dangerous infection in the feet and hands often occurring with uncontrolled diabetes. It appears that high blood sugar unleashes destructive molecules that interfere with the body's natural infection-control defenses.

7 Aug 2015

in vivo News and Research

University of Nottingham to lead £6.5m research project that aims to develop next generation biomaterials

Transplanting multi-layered sheet of liver cells into damaged liver improves function in test animals

ASTRO awards $675,000 to seven physician-researchers to advance radiation oncology research

Researchers evaluate use of human fetal progenitor tenocyte to repair tendon injuries

Synthorx employs synthetic DNA technology to produce proteins containing novel amino acids

Researchers test new non-invasive technique that can accurately detect malignant melanoma

Putaminal serotonergic innervation flags levodopa-induced dyskinesia risk

GlySens secures FDA approval to extend current human clinical evaluation of fully implanted CGM system

Researchers reveal how migrating tumour cells produce protein that helps set up home in bones

Nitrogen oxides affect pollen of common ragweed plant

Centenary Institute researchers take lead on promising new class of drugs for melanoma treatment

New endoscopic system differentiates between malignant and benign tumors in gastrointestinal tract

Scientists reveal how non-allergenic pollen mediators can increase allergic reactions

Researcher study potential biomarker to determine patients at risk for aggressive breast cancer

Embryonic stem cells may help researchers to study physiological effects of environmental pollutants on human health

LA BioMed's Nagendra Mishra to be honored with 2015 ICAAC Young Investigator Award

Novel treatment target found for RV failure in PAH

Turing Pharmaceuticals acquires rights to market Daraprim (pyrimethamine) in the U.S.

Vascular side effects prevent first-line ponatinib use in chronic phase CML

Study may lead to effective antimicrobial treatment strategies for people with uncontrolled diabetes

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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