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Body fat may promote inflammation

Why does extra fat around the waist increase the risk of heart disease? A new study by Wake Forest University Baptist Medical Center researchers and colleagues suggests that inflammation may be the key.

28 Mar 2005

Gene variations explain drug dose required to control seizures

Determining which variants of particular genes patients with epilepsy carry might enable doctors to better predict the dose of drugs necessary to control their seizures, suggest basic findings by researchers at the Duke University Institute for Genome Sciences & Policy (IGSP) and the University College London.

28 Mar 2005

Variation in the gene ENPP1 may predict risk for diabetes

A particular gene variant that could serve as a predictor for type 2 diabetes has been identified by researchers at UT Southwestern Medical Center.

28 Mar 2005

Gene/yeast finding links processes in heart disease and cancer

By studying a little-known yeast too primitive to get diseases, Johns Hopkins researchers have uncovered a surprising link between two processes at play in heart disease and cancer in people.

28 Mar 2005

Three different leukemias are all caused by mutations that alter a specific enzyme controlling blood cell proliferation

Identifying the genetic malfunction that causes these disorders raises the hope that researchers may be able to devise a targeted therapy, just as they have done for chronic myelogenous leukemia (CML), which is presently treated with Gleevec. The three leukemias that share a common genetic cause are polycythemia vera (PV), essential thrombocythemia (ET) and myeloid metaplasia with myelofibrosis (MMM).

28 Mar 2005

Test that will prevent the needless loss of the thyroid gland in people with the noncancerous condition

New research suggests that physicians can distinguish between a type of thyroid cancer and an identical-looking, non-cancerous thyroid condition by simply determining the activity of three genes.

28 Mar 2005

New directions toward the treatment of bipolar disorder

While lithium treatment has proven to be a godsend for many of the two million Americans with bipolar disorder, it is not without its downside. People on the drug may develop hypothyroidism, tremors, cognitive impairment, and excessive thirst and urination and gain weight.

23 Mar 2005

New guidelines mean tailor-made drugs are on the way

Many experts believe a milestone has been reached with the issuing of guidelines for pharmaceutical companies to encourage them to gather and submit information about how genetic variations affect the way people respond to their drugs.

23 Mar 2005

Ultrafast laser detection of cancer cells also may improve understanding of stem cells

To investigate tumors, pathologists currently rely on labor-intensive microscopic examination, using century-old cell-staining methods that can take days to complete and may give false readings.

23 Mar 2005

Gene linked to bone mineral density

Sequenom has announced the discovery of a genetic variation in the gene encoding phosphodiesterase 4D (PDE4D) that is believed to affect osteoporosis risk. Fragility fractures caused by osteoporosis are a major cause of morbidity and mortality in the aging population.

23 Mar 2005

Docosahexaenoic acid may protect against the accumulation of a protein believed to be linked to Alzheimer's disease

Docosahexaenoic acid (DHA), an omega-3 fatty acid, may protect against the accumulation of a protein believed to be linked to Alzheimer's disease, according to the results of a new study published in the March 30, 2005 issue of The Journal of Neuroscience. The study used Martek DHA, which is produced from microalgae.

23 Mar 2005

1 out of 7 minority women lack important family history of breast cancer

Having your doctor ask you about your family breast health history can greatly increase the chances of identifying your risk for breast cancer.

23 Mar 2005

Gene named ATBF1 may contribute to the development of prostate cancer

A gene named ATBF1 may contribute to the development of prostate cancer through acquired mutations and/or loss of expression, according to research at Emory University School of Medicine and its Winship Cancer Institute.

23 Mar 2005

Scientists have found genetic regions that, when defective, allow the immune system to attack the pancreas

Scientists at Joslin Diabetes Center have found genetic regions that, when defective, allow the immune system to attack the pancreas -- the first in a series of mis-steps that lead to type 1 diabetes. Armed with these findings, published yesterday, March 22, in the journal Immunity, the researchers are now trying to hone in on the exact genes involved, in mice and in human patients.

23 Mar 2005

Preventing eye disease in retinitis pigmentosa

Retinitis pigmentosa (RP) is an inherited eye disease that causes visual disability leading to blindness. Over the last 15 years, researchers have pinpointed defects in dozens of genes causing different forms of RP.

22 Mar 2005

Study suggests combination therapy could stop spread, halt growth of melanomas

Researchers at Penn State College of Medicine have identified the mechanism by which the most mutated gene in melanoma, called v599EB-Raf, aids melanoma tumor development demonstrating its importance as a therapeutic target.

22 Mar 2005

Oral contraceptives may protect against breast cancer

Women at high genetic risk of breast cancer could reduce their risk of developing the disease at an early age by taking oral contraceptives, a new study has found. The findings contradict previous studies, which suggested oral contraceptive use would increase the risk of developing breast cancer.

22 Mar 2005

Tiny scaffolding allows stem cells to become working fat cells

Researchers here have used a new microscopic, three-dimensional scaffolding to coax mouse stem cells to transform themselves into fat cells, and then to function identical to how fat cells naturally do in the body.

22 Mar 2005

Genes TEL2 and MYC cooperate with each other to promote pediatric cases of the immune system cancer B-cell lymphoma

The genes TEL2 and MYC cooperate with each other to promote pediatric cases of the immune system cancer B-cell lymphoma. This finding, from investigators at St. Jude Children's Research Hospital, is published in the current issue of Molecular Cell Biology (MCB).

22 Mar 2005

Findings are expected to yield new diagnostic and therapeutic tools in the battle against cancer

New laboratory findings at the University of Illinois at Chicago suggest that what lies outside cancer cells is at least as important as the genes inside in explaining a tumor's malignancy.

22 Mar 2005