Clinical Trial News and Research

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The effects of taurine supplementation on biomarkers of oxidative stress in women aged 55 to 70

Researchers investigated the effects of supplementing taurine on the biomarkers of oxidative stress in females.

8 Sep 2022

Plants and plant-derived preparations as co-treatments for COVID-19

A recent Journal of Medicinal Food study proposed a comprehensive guideline for applying plants and plant-derived formulations to co-treat severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and other viral infections.

8 Sep 2022

Administering immunotherapy drug before surgery for oral cavity cancer did not increase complications

A University of Cincinnati study found administering an immunotherapy drug before surgery for oral cavity cancer did not lead to increased rates of complications during and after surgery.

7 Sep 2022

New research focuses on restoring movement after spinal cord injury

People with spinal cord injuries often experience life-long movement impairment or paralysis, for which there is no cure. When coupled with rehabilitative exercise, electrical spinal cord stimulation can help restore some movement, though the mechanisms of how the nerves in the spinal cord recover are unknown.

6 Sep 2022

Combined stem cell and gene therapy shows promise to treat patients with ALS

Cedars-Sinai investigators have developed an investigational therapy using support cells and a protective protein that can be delivered past the blood-brain barrier.

5 Sep 2022

Study investigates the effect of vitamin D and fish oil on croup

Babies and children under three years old are less likely to develop croup if their mothers took fish oil and vitamin D supplements during pregnancy, according to new results from a clinical trial. The findings are from a randomised controlled trial – the 'gold standard' for medical research – that will be presented at the European Respiratory Society International Congress in Barcelona, Spain. It is the first large study of its kind to investigate the effects of vitamin D and fish oil on croup.

5 Sep 2022

MHRA approves bivalent COVID-19 booster vaccine made by Pfizer/BioNTech

A second, "bivalent" vaccine has today been approved as a booster by the Medicines and Healthcare products Regulatory Agency (MHRA) after it was found to meet the UK regulator's standards of safety, quality and effectiveness.

3 Sep 2022

Clinical trial shows efficacy and safety of belimumab in East Asian adults with lupus nephritis

This prespecified subgroup analysis of East Asian adults who participated in a phase 3 clinical trial of belimumab added to standard therapy vs. placebo added to standard therapy for lupus nephritis shows earlier and more sustained improvement in kidney outcomes with the addition of belimumab.

2 Sep 2022

Men with low testosterone may have higher risk of COVID-19 hospitalization

Men with low testosterone who develop COVID-19 are at elevated risk of becoming seriously ill and ending up in the hospital, according to a study by researchers at Washington University School of Medicine in St. Louis and Saint Louis University School of Medicine.

2 Sep 2022

What is the risk of BA.5 infection among persons with documented infection with past variants?

A recent correspondence discussed a study in which researchers assessed the infection risk for the SARS-CoV-2 Omicron BA.5 subvariant in vaccinated people exposed to previous SARS-CoV-2 variants.

2 Sep 2022

GnRH therapy could improve cognitive deficits in men with Down syndrome

Gonadotropin-releasing hormone (GnRH) therapy improves cognitive function in Down syndrome (DS) mouse models and male patients with DS, according to a new study.

1 Sep 2022

Study shows encouraging therapeutic options for patients with relapsed multiple myeloma

Mount Sinai researchers have published results that show encouraging therapeutic options for patients with the blood cancer multiple myeloma after first-line treatment with bispecific antibodies fails.

1 Sep 2022

Immune cells beyond CAR-T cells affect the durability of response to BCMA CAR T therapy in myeloma

Patients with myeloma whose tumor immune microenvironments had a more diverse baseline T-cell repertoire, fewer markers of immune cell exhaustion, and distinct changes to immune cell populations were more likely to have longer progression-free survival (PFS) after treatment with BCMA-targeted T-cell therapy.

30 Aug 2022

Using human tissue models to improve treatment and diagnosis of heart attacks

A heart attack, or myocardial infarction, is one of the leading causes of mortality worldwide, resulting in 18 million deaths per year.

30 Aug 2022

Cedars-Sinai investigators create new blood test for early detection of common liver cancer

Cedars-Sinai Cancer investigators have created a blood test that uses a technology made commonly available during the COVID-19 pandemic to detect the most common form of liver cancer - at an early enough stage that cure is possible.

30 Aug 2022

AI proves to be more accurate in diagnosing cardiac function than sonographers

In a first-of-its-kind randomized clinical trial led by researchers at the Smidt Heart Institute and the Division of Artificial Intelligence in Medicine at Cedars-Sinai, artificial intelligence (AI) proved more successful in assessing and diagnosing cardiac function when compared to echocardiogram assessments made by sonographers.

29 Aug 2022

Implanted brain-stimulating device disrupts craving-related signals and reduces bingeing episodes

A small device that detects food craving-related brain activity in a key brain region, and responds by electrically stimulating that region, has shown promise in a pilot clinical trial in two patients with loss-of-control binge eating disorder (BED), according to researchers at the Perelman School of Medicine at the University of Pennsylvania.

29 Aug 2022

Full-dose anticoagulation lowers the risk of blood clotting complications in COVID-19 patients

A clinical trial of patients with COVID-19 led by investigators at the TIMI Study Group at Brigham and Women's Hospital and the Critical Care Cardiology Trials Network has found that full-dose anticoagulation lowers the risk of blood clotting complications compared with standard-dose prophylactic anticoagulation.

29 Aug 2022

New risk assessment tool predicts mortality for atrial fibrillation patients after completion of TAVR

A large-scale international study led by Mount Sinai has yielded the first risk score that can help predict mortality for patients with atrial fibrillation (AFib) who have undergone a successful transcatheter aortic valve replacement (TAVR) and discharged home.

29 Aug 2022

Trial shows superiority of AI in assessing cardiac function to sonographer assessment

In patients undergoing echocardiographic evaluation of cardiac function, preliminary assessment by artificial intelligence (AI) is superior to initial sonographer assessment, according to late breaking research presented in a Hot Line session today at ESC Congress 2022.

28 Aug 2022

Clinical Trial News and Research

The effects of taurine supplementation on biomarkers of oxidative stress in women aged 55 to 70

Plants and plant-derived preparations as co-treatments for COVID-19

Administering immunotherapy drug before surgery for oral cavity cancer did not increase complications

New research focuses on restoring movement after spinal cord injury

Combined stem cell and gene therapy shows promise to treat patients with ALS

Study investigates the effect of vitamin D and fish oil on croup

MHRA approves bivalent COVID-19 booster vaccine made by Pfizer/BioNTech

Clinical trial shows efficacy and safety of belimumab in East Asian adults with lupus nephritis

Men with low testosterone may have higher risk of COVID-19 hospitalization

What is the risk of BA.5 infection among persons with documented infection with past variants?

GnRH therapy could improve cognitive deficits in men with Down syndrome

Study shows encouraging therapeutic options for patients with relapsed multiple myeloma

Immune cells beyond CAR-T cells affect the durability of response to BCMA CAR T therapy in myeloma

Using human tissue models to improve treatment and diagnosis of heart attacks

Cedars-Sinai investigators create new blood test for early detection of common liver cancer

AI proves to be more accurate in diagnosing cardiac function than sonographers

Implanted brain-stimulating device disrupts craving-related signals and reduces bingeing episodes

Full-dose anticoagulation lowers the risk of blood clotting complications in COVID-19 patients

New risk assessment tool predicts mortality for atrial fibrillation patients after completion of TAVR

Trial shows superiority of AI in assessing cardiac function to sonographer assessment

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