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Genetic defect leads to electrical instability and mechanical pump failure

In genetic mapping of a large family with several members affected by a type of heart failure called dilated cardiomyopathy (DCM), the Mayo Clinic team found a defect in a gene on chromosome 3 called SCN5A.

26 Jan 2005

Research may provide the basis for development of a new, extensive immunotherapy for human tumors

Scientists have made significant progress towards understanding how the immune system can be more specifically and efficiently targeted against cancer cells. The research, published in the January issue of Immunity, may provide the basis for development of a new, extensive immunotherapy for human tumors.

26 Jan 2005

Plant protein mimics hormone that mitigates diabetes and obesity

A common protein that protects plants from fungal infection mimics the activity of a hormone in mammals that is linked to weight loss and is believed to play a role in mitigating heart disease, obesity and diabetes, according to a team of researchers at Purdue University and several collaborating institutions.

25 Jan 2005

By age six, children of overweight mothers are fifteen times more likely to be obese

By age six, children of overweight mothers are fifteen times more likely to be obese than children of lean mothers. The research, at The Children's Hospital of Philadelphia and the University of Pennsylvania, showed the strength of genetic influences, and suggests that efforts to prevent obesity should focus on such children at risk, preferably by four years of age.

25 Jan 2005

Modern humans have sloppy gene control mechanisms which can make us susceptible to diseases

Our evolutionary ancestors’ lack of choice in the mating game has left modern humans exposed to disease, according to new research published in the journal PLOS Biology today.

25 Jan 2005

High blood pressure risk in African-Americans linked to genetics

National health records have shown that African-Americans are more prone to high blood pressure than Caucasians, but pinning down the roots of that difference has proven elusive. Now, researchers at the Stanford University School of Medicine have narrowed down the search for genes that contribute to this difference in disease risk.

24 Jan 2005

Scientists unravel first step in translating genetic information in order to build a protein

Timing is everything, it seems, even in science. A team led by Johns Hopkins scientists has unraveled the first step in translating genetic information in order to build a protein, only to find that it's not one step but two.

24 Jan 2005

Jeans too tight, then check your genes

If you're a middle-aged guy who's packed on the pounds and now is battling to take them off, it's a 50-50 shot that your jeans are fitting tighter because of your genes, according to a Saint Louis University School of Public Health study.

20 Jan 2005

ID Biomedical begins development of pandemic influenza vaccine

ID Biomedical announced today that it has begun development of an experimental ("mock") vaccine against a strain of the influenza virus, H5N1, that experts believe could cause a deadly worldwide epidemic (pandemic) of influenza.

19 Jan 2005

Cellular fuel gauge could hold clue to diabetes

A molecule in the body could hold the key to explaining why people who exercise regularly are less likely to have illnesses such as type 2 diabetes.

19 Jan 2005

Scientists identify fat gene

UCLA/VA scientists have identified a new gene that controls how the body produces and uses fat. Called lipin, the gene may provide a new target for therapies to control obesity, diabetes and other weight-related disorders. The first issue of the new journal Cell Metabolism publishes the findings in its January 2005 edition.

19 Jan 2005

Newly discovered virus, New Haven coronavirus

A newly discovered virus may be responsible for many respiratory tract illnesses in infants and children, and may be associated with an important multi-organ disease whose cause has remained a mystery for decades, according to articles in the Feb. 15 issue of The Journal of Infectious Diseases, now available online.

19 Jan 2005

Memory problems could be a clue to psychosis

University of Melbourne researchers have identified a variety of intellectual impairments, such as difficulties young people have in remembering new information, that could be a marker for later psychosis.

18 Jan 2005

Single gene mutation as the cause of around one in 25 cases of Parkinson’s disease worldwide

The studies suggest that the mutation, in a recently discovered gene called LRRK2, causes around 5% of inherited Parkinson’s cases and around 2% of isolated cases. Screening for the new mutation is likely to become a component of genetic testing for Parkinson’s disease in the near future.

17 Jan 2005

Animal study on vascular effects of COX-2 inhibition

In an article by Egan et al, titled, "Cyclooxygenases, Thromboxane, and Atherosclerosis," published in the Jan 17 issue of Circulation: Journal of the American Heart Association researchers examined some of the molecular mechanisms of drugs affecting prostaglandin and thromboxane production.

17 Jan 2005

Origins of racial health disparities can involve both genes and environment and the interactions between them

New understanding of the dynamic interplay between genes and environment, made possible by technologies arising from the Human Genome Project, helps support the individualization of medicine and makes focusing on racial or ethnic group differences in disease less relevant, say Penn State researchers.

17 Jan 2005

Research leads to new antiangiogenic drugs

Scientists have uncovered critical information that may lead to an urgently needed method for effective monitoring of antiangiogenic cancer therapies.

17 Jan 2005

Anti-seizure drugs slow aging in roundworms

Researchers at Washington University School of Medicine in St. Louis have discovered that a class of anti-seizure medications slows the rate of aging in roundworms. The worms, when exposed to drugs used to treat epilepsy in humans, lived longer and retained youthful functions longer than normal.

17 Jan 2005

Human Genome Project may have made traditional race-based measurements of human differences obsolete

New and sophisticated methods for studying the relationship between human genetic differences, the environment, health and behavior, all made possible by the completion of the Human Genome Project, have made traditional race-based measurements of human differences obsolete

17 Jan 2005

Missing sequence of the human Y chromosome may contain genes controlling stature and tumor development

Scientists have reported in the journal Genome Research that they have successfully cloned and characterized a previously intractable DNA sequence: a 554-kilobase-pair genomic segment near the centromere of the human Y chromosome. This sequence contains eight putatively active genes that could be implicated in sex-associated height differences and gonadal tumor development.

16 Jan 2005

Genetic News and Research

Genetic defect leads to electrical instability and mechanical pump failure

Research may provide the basis for development of a new, extensive immunotherapy for human tumors

Plant protein mimics hormone that mitigates diabetes and obesity

By age six, children of overweight mothers are fifteen times more likely to be obese

Modern humans have sloppy gene control mechanisms which can make us susceptible to diseases

High blood pressure risk in African-Americans linked to genetics

Scientists unravel first step in translating genetic information in order to build a protein

Jeans too tight, then check your genes

ID Biomedical begins development of pandemic influenza vaccine

Cellular fuel gauge could hold clue to diabetes

Scientists identify fat gene

Newly discovered virus, New Haven coronavirus

Memory problems could be a clue to psychosis

Single gene mutation as the cause of around one in 25 cases of Parkinson’s disease worldwide

Animal study on vascular effects of COX-2 inhibition

Origins of racial health disparities can involve both genes and environment and the interactions between them

Research leads to new antiangiogenic drugs

Anti-seizure drugs slow aging in roundworms

Human Genome Project may have made traditional race-based measurements of human differences obsolete

Missing sequence of the human Y chromosome may contain genes controlling stature and tumor development

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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