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ANU researchers develop cholesterol-based trojan horse method to target malaria parasites

More than a quarter of Australians over the age of 50 take cholesterol-lowering drugs to prevent heart disease and strokes, but our bodies also need cholesterol to survive.

13 Aug 2024

Researchers discover a novel pathway to wake up dormant neural stem cells

Scientists from Duke-NUS Medical School and the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) have discovered a novel pathway to wake up dormant neural stem cells, offering potential new therapies for neurodevelopmental disorders such as autism, learning disabilities, and cerebral palsy.

13 Aug 2024

Are personality traits linked to psychiatric disorders? Genome-wide study reveals genetic connections

Researchers identified 208 significant loci for neuroticism, revealing complex genetic influences on personality traits and their links to psychiatric conditions like depression and anxiety.

13 Aug 2024

New insights into lipid-induced senescence in dopaminergic neurons

A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 14 on July 19, 2024, entitled, "Lipid accumulation drives cellular senescence in dopaminergic neurons."

13 Aug 2024

Australia leads life expectancy among English-speaking nations

Australians outlive their peers in five other high-income English-speaking countries by 1 to 4 years, with most of this advantage seen between ages 45 and 84. Lower death rates from drug and alcohol misuse, treatable cancers, and cardiovascular diseases are key factors.

13 Aug 2024

New insights into the pharmacokinetics of remdesivir in treating SARS-CoV-2 in pregnant women

A new study provides important insights into the pharmacokinetics and safety of intravenous remdesivir in treating the SARS-CoV-2 coronavirus in pregnant women.

13 Aug 2024

Two studies uncover how immunotherapies work together to activate immune responses in melanoma

Two studies published in the latest issue of the journal Cell by University of Pittsburgh researchers uncover how immunotherapies targeting the immune checkpoints PD1 and LAG3 work together to activate immune responses.

13 Aug 2024

IU research sheds light on urea cycle defects and fatty liver disease

An Indiana University School of Medicine physician scientist is making strides in understanding the molecular origins of fatty liver disease, a leading cause of liver failure in the United States.

13 Aug 2024

AlphaFold accelerates discovery of potential antipsychotic drugs by outperforming traditional methods

Researchers used AlphaFold and homology modeling to identify potent TAAR1 agonists, showing AlphaFold's superior performance in drug discovery for neuropsychiatric conditions.

13 Aug 2024

Common antibiotics linked to severe skin reactions, study warns doctors to choose wisely

Research reveals that sulfonamides and cephalosporins significantly increase the risk of serious cutaneous adverse drug reactions, highlighting the importance of careful antibiotic selection in elderly patients.

12 Aug 2024

Researchers develop new method to study critical type of protein modification process

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability.

12 Aug 2024

Beyond neurons: Glial cells identified as key players in Alzheimer's disease

Memory loss, confusion, speech problems – Alzheimer's disease is the most common cause of dementia, affecting about 35 million people worldwide, and the number is growing.

12 Aug 2024

Novel exosome-based drug delivery system for synergistic cancer treatment

Ovarian cancer is one of the most common malignancies in women worldwide. Unlike breast cancer, ovarian cancer lacks early diagnostic markers and does not show noticeable symptoms until cancer metastases, leading to a low survival rate for ovarian cancer patients.

12 Aug 2024

MUSC researchers uncover the surprising role of the dorsal peduncular nucleus in opioid addiction

Opioids, like the commonly prescribed pain reliever oxycodone, are known for being highly addictive. In 2022, nearly 85,000 people died from an opioid overdose in the U.S. according to the Centers for Disease control.

12 Aug 2024

Study reveals how NPAS4 regulates drug-context associations and impacts relapse

Most people wouldn't think twice after seeing sugar spilled on a counter. But for someone with a history of cocaine use, this visual cue could trigger powerful associations with their past drug use and a compulsive urge to seek the drug.

9 Aug 2024

Breakthrough study identifies intestinal epithelium's role in celiac disease gluten response

People with celiac disease must navigate everyday life by avoiding gluten, a protein in wheat, rye and barley which can trigger painful symptoms in the gut, impede the absorption of nutrients and raise the risk of other serious long-term issues.

9 Aug 2024

Review explores potential for improved use of anti-angiogenic agents in cancer therapy

Most tumors release various signaling molecules to support their incessant growth, invasion, and metastasis.

9 Aug 2024

Breakthrough in the synthesis of fungal bioactive compounds for therapeutic applications

The natural world is rich in chemical compounds with remarkable medicinal properties. A notable example is penicillin, discovered by chance from the Penicillium mold.

9 Aug 2024

DeepPBS: A geometric AI model for accurate prediction of protein-DNA binding specificity

A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a technological advance that promises to reduce the time required to develop new drugs and other medical treatments.

9 Aug 2024

Korean researchers accelerate race for respiratory disease cures

The COVID-19 pandemic has profoundly impacted our lives, claiming nearly 7.1 million lives globally. Scientists and medical professionals have been working tirelessly to understand the virus, its transmission pathways, and effective treatments. The urgency of developing vaccines and treatments has never been greater, prompting calls for Korea to expedite its drug development efforts to match those of developed countries. Recently, a team of Korean researchers has made a breakthrough that will greatly enhance the efficiency of respiratory disease research, garnering attention.

9 Aug 2024

Drugs News and Research

ANU researchers develop cholesterol-based trojan horse method to target malaria parasites

Researchers discover a novel pathway to wake up dormant neural stem cells

Are personality traits linked to psychiatric disorders? Genome-wide study reveals genetic connections

New insights into lipid-induced senescence in dopaminergic neurons

Australia leads life expectancy among English-speaking nations

New insights into the pharmacokinetics of remdesivir in treating SARS-CoV-2 in pregnant women

Two studies uncover how immunotherapies work together to activate immune responses in melanoma

IU research sheds light on urea cycle defects and fatty liver disease

AlphaFold accelerates discovery of potential antipsychotic drugs by outperforming traditional methods

Common antibiotics linked to severe skin reactions, study warns doctors to choose wisely

Researchers develop new method to study critical type of protein modification process

Beyond neurons: Glial cells identified as key players in Alzheimer's disease

Novel exosome-based drug delivery system for synergistic cancer treatment

MUSC researchers uncover the surprising role of the dorsal peduncular nucleus in opioid addiction

Study reveals how NPAS4 regulates drug-context associations and impacts relapse

Breakthrough study identifies intestinal epithelium's role in celiac disease gluten response

Review explores potential for improved use of anti-angiogenic agents in cancer therapy

Breakthrough in the synthesis of fungal bioactive compounds for therapeutic applications

DeepPBS: A geometric AI model for accurate prediction of protein-DNA binding specificity

Korean researchers accelerate race for respiratory disease cures

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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