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Novel targeted therapy blocks metabolic pathways in cancer cells with specific genetic defects

Researchers at The University of Texas MD Anderson Cancer Center have developed a novel targeted therapy, called POMHEX, which blocks critical metabolic pathways in cancer cells with specific genetic defects.

23 Nov 2020

Basic concepts lay the foundation for personalized immunotherapy

Personalized Immunotherapy for Tumor Diseases and Beyond introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for the immunotherapy of patients.

23 Nov 2020

Analysis shows social distancing helped reduce nosocomial SARS-CoV-2 transmission in London

Recently, a team of researchers from the King's College London, Guy's and St Thomas' NHS Foundation Trust, and St Thomas' Hospital, London analyzed comprehensive epidemiological and viral nanopore sequence data from 574 patients with SARS-CoV-2 infection confirmed by a PCR test in March 2020.

22 Nov 2020

Researchers investigate SARS-CoV-2 transmission chain dynamics in the Nordic countries

To date, the coronavirus disease (COVID-19) pandemic has affected over 58.52 million individuals and led to more than 1.38 million deaths worldwide. Second waves of the pandemic are still ongoing in many countries with a massive impact on health care systems and economies.

22 Nov 2020

Researchers receive $8.3 million NIH grant to illuminate the causes of spina bifida

Researchers at University of California San Diego School of Medicine, in collaboration with Rady Children's Institute for Genomic Medicine, have been awarded a five-year, $8.3 million grant from the National Institutes of Health's Eunice Kennedy Shriver National Institute of Child Health and Human Development to further illuminate the causes of spina bifida, the most common structural defect of the central nervous system.

20 Nov 2020

Scientists explain potential reasons for SARS-CoV-2 re-infection

A study, which was published in the journal New Microbes and New Infections, focused on the possible reasons for SARS-CoV-2 reinfection.

20 Nov 2020

Cannabis use disorder may increase risk of COVID-19 hospitalization

Researchers in the United States have conducted a study suggesting that genetic vulnerability to a psychiatric syndrome called cannabis use disorder (CUD) may increase the risk of developing severe coronavirus disease 2019 (COVID-19) that requires hospitalization.

19 Nov 2020

TB researchers uncover crucial clue that explains antibiotic resistance in bacteria

For a slow-growing microbe that multiplies infrequently, Mycobacterium tuberculosis, the pathogen that causes tuberculosis (TB) has long puzzled researchers as to how it develops resistance to antibiotics so quickly, in a matter of weeks to months.

18 Nov 2020

Researchers use single-cell analysis to assess effects of aging on mice’s egg cells

Using the power of single-cell analysis, researchers at the Babraham Institute have assessed the effects of age on egg cells (oocytes) in mice, particularly looking to identify genomic and epigenetic factors that relate to reduced developmental competence.

18 Nov 2020

UTHSC and Regeneron partner to advance precision medicine

The University of Tennessee Health Science Center has entered into an agreement with the Regeneron Genetics Center, a subsidiary of Regeneron Pharmaceuticals, Inc., for the company to sequence DNA that has been voluntarily collected and stored as part of a biorepository initiative UTHSC is building in collaboration with its partner teaching hospitals.

18 Nov 2020

Researchers use proteogenomics to better understand the biological complexity of breast cancer

Researchers at Baylor College of Medicine, the Broad Institute of MIT and Harvard and other institutions have applied powerful proteogenomics approaches to better understand the biological complexity of breast cancer.

18 Nov 2020

Ancient East Asian peoples may have adapted to coronavirus-like epidemic up to 25,000 years ago

A new study by researchers at the University of Adelaide and Australian National University in Australia and the University of Arizona in the US shows that an ancient coronavirus-like epidemic drove the adaptation of East Asian peoples from 25,000 to 5,000 years ago.

18 Nov 2020

Accelerated biological aging not a risk factor for severe COVID-19, say researchers

A new study conducted by researchers at RWTH Aachen University in Germany has found no evidence to support the hypothesis that severe outcomes in cases of coronavirus disease 2019 (COVID-19) may be linked to accelerated biological aging.

17 Nov 2020

New rapid algorithm could help trace hospital-derived SARS-CoV-2 infections

A new study reports a rapid method that uses two different routes to swiftly trace the onset of infection to a putative hospital source. This could be immensely helpful for preventing and controlling infection, once validated.

17 Nov 2020

Sanger Institute and COG-UK get £12.2M funding to build genomic surveillance system for COVID-19

The Department for Health and Social Care Testing Innovation Fund has backed the Wellcome Sanger Institute and the COVID-19 Genomics UK Consortium in expanding whole genome sequencing of positive SARS-CoV-2 virus samples to map how COVID-19 spreads and evolves.

16 Nov 2020

UCLA Health collaborates with Regeneron Genetics Center to bring genomic medicine to patients

UCLA Health has entered into a collaborative research agreement with the Regeneron Genetics Center (RGC) to provide whole exome sequencing for 150,000 UCLA Health patients.

16 Nov 2020

Study reveals key role of IL-33 signaling molecule in parasite infections, other health conditions

De'Broski Herbert has a philosophy that's guided his career researching helminths, or parasitic worms, and their interaction with their hosts' immune systems: "Follow the worm."

15 Nov 2020

Peptide-conjugated morpholino oligomers effectively inhibit SARS-CoV-2 in vero cells

The hunt for antivirals has reached an unprecedented pace in light of the coronavirus 2019 (COVID-19) pandemic. The causal agent for this disease – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – has already infected over 52 million people worldwide, and has subsequently claimed over 1.3 million lives. However, among the innumerable promising drug candidates that help battle the virus and mitigate its damage, none have yet made it to the clinic.

12 Nov 2020

Rhesus monkeys and cats potential spillover reservoirs for COVID-19 virus

A team of researchers from Switzerland, Costa Rica and Germany has conducted a study showing which animal species could potentially serve as spillback reservoirs of severe acute repertory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

12 Nov 2020

Spike-based DNA vaccine shows excellent protection against SARS-CoV-2 in a hamster model

A study conducted at the United States Army Research Institute of Infectious Diseases shows how a relatively simple full-length DNA vaccine against spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can elicit neutralizing antibody response in an animal model – even after a single shot with simple jet injection technique.

11 Nov 2020

Genomic News and Research

Novel targeted therapy blocks metabolic pathways in cancer cells with specific genetic defects

Basic concepts lay the foundation for personalized immunotherapy

Analysis shows social distancing helped reduce nosocomial SARS-CoV-2 transmission in London

Researchers investigate SARS-CoV-2 transmission chain dynamics in the Nordic countries

Researchers receive $8.3 million NIH grant to illuminate the causes of spina bifida

Scientists explain potential reasons for SARS-CoV-2 re-infection

Cannabis use disorder may increase risk of COVID-19 hospitalization

TB researchers uncover crucial clue that explains antibiotic resistance in bacteria

Researchers use single-cell analysis to assess effects of aging on mice’s egg cells

UTHSC and Regeneron partner to advance precision medicine

Researchers use proteogenomics to better understand the biological complexity of breast cancer

Ancient East Asian peoples may have adapted to coronavirus-like epidemic up to 25,000 years ago

Accelerated biological aging not a risk factor for severe COVID-19, say researchers

New rapid algorithm could help trace hospital-derived SARS-CoV-2 infections

Sanger Institute and COG-UK get £12.2M funding to build genomic surveillance system for COVID-19

UCLA Health collaborates with Regeneron Genetics Center to bring genomic medicine to patients

Study reveals key role of IL-33 signaling molecule in parasite infections, other health conditions

Peptide-conjugated morpholino oligomers effectively inhibit SARS-CoV-2 in vero cells

Rhesus monkeys and cats potential spillover reservoirs for COVID-19 virus

Spike-based DNA vaccine shows excellent protection against SARS-CoV-2 in a hamster model

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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