Cell Proliferation News and Research

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Scientists identify key driver in BRAF inhibitor resistant melanoma

Targeted therapy with BRAF-MEK inhibitors is an effective treatment for patients with advanced melanoma that cannot be surgically removed or has spread to other areas of the body.

2 Sep 2020

SARS-CoV-2-RNA viremia is a robust marker of critical illness in COVID-19

A new study by a large team of Spanish researchers and published on the preprint server medRxiv* in August 2020 reports that the presence of viral RNA in the blood is a useful marker of impending acute disease and can help triage COVID-19 disease patients who will require hospital care.

1 Sep 2020

New dual CAR T cell immunotherapy shows enhanced therapeutic potency to fight HIV

A recent study published in the journal Nature Medicine, led by researchers Todd Allen, PhD, a professor of Medicine at Harvard Medical School and group leader at the Ragon Institute of MGH, MIT and Harvard, and Jim Riley, PhD, a professor of Microbiology in the Perelman School of Medicine at the University of Pennsylvania, describes a new Dual CAR T cell immunotherapy that can help fight HIV infection.

31 Aug 2020

Newly designed hydrogels allow the culture of T-cells for use in cancer immunotherapy

A team with the participation of researchers from the Spanish National Research Council has designed new hydrogels that allow the culture of T-cells or T-lymphocytes, cells of the immune system that are used in cancer immunotherapy since they have the capacity to destroy tumor cells.

31 Aug 2020

Researchers identify RNA molecule that aids in lung cancer immune evasion

Researchers in Spain have identified a non-coding RNA molecule that helps lung cancer cells proliferate and avoid being killed by the body's immune cells.

27 Aug 2020

Study identifies a novel regulatory pathway in bladder cancer

Researchers from Johns Hopkins University in collaboration with Insilico Medicine announce the publication of a new research paper titled "GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma" in Science Signaling.

20 Aug 2020

Whey protein from human breastmilk inhibits SARS-CoV-2 infection

Many scientists have reported the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on pregnancy and the virus has been detected in breastmilk. Now a new study published on the preprint server bioRxiv* in August 2020 shows that whey protein in human breastmilk efficiently prevents infection with SARS-CoV-2 as well as post-entry viral replication.

20 Aug 2020

Researchers develop implantable hydrogels based on plant polysaccharides

Far Eastern Federal University (FEFU) scientists have developed implantable hydrogels based on plant polysaccharides (pectins). They can play the role of an artificial extracellular matrix, a special network of molecules that fills the space between body cells.

14 Aug 2020

Oxygen-deprived breast cancer cells send out messages that promote cancer progression

According to a study by The Wistar Institute, breast cancer cells starved for oxygen send out messages that induce oncogenic changes in surrounding normal epithelial cells.

11 Aug 2020

DHODH inhibitor PTC299 shows potential as a COVID-19 therapeutic

As COVID-19 continues to take a heavy toll on human health and life in many parts of the world, there is still no effective antiviral drug or vaccine. This has fueled an intensive search for small molecules and proteins that can inhibit viral entry and replication.

10 Aug 2020

Nanomedicine-based strategy enhances anti-PD1 therapy to eradicate PTEN-negative GBM

A nanomedicine-based strategy for chemo-immunotherapy (CIT) of glioblastoma (GBM), which has the worst prognosis among brain tumors, was successfully developed.

7 Aug 2020

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

A new alpha-radioimmunotherapy, 212Pb-anti-CD38, has proven effective in preventing tumor growth and increasing survival in multiple myeloma tumor-bearing mice, according to new research published in the July issue of the Journal of Nuclear Medicine. Given the long half-life, central production and worldwide distribution of 212Pb-anti-CD38, researchers have determined that the α-radioimmunotherapy is not only effective but also clinically feasible as a multiple myeloma treatment.

6 Aug 2020

Hyperbaric oxygen therapy can enhance the cognitive performance of healthy older adults

The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center, together with the Sackler School of Medicine and Sagol School of Neuroscience at Tel Aviv University, announced today that a peer-reviewed study has demonstrated for the first time that hyperbaric oxygen therapy (HBOT) can significantly enhance the cognitive performance of healthy older adults.

15 Jul 2020

Aspirin and flavonoids in fruits and vegetables could help prevent colorectal cancer

A diet rich in fruits and vegetables and a daily dose of aspirin have one thing in common-;both can help prevent colorectal cancer. Yet scientists have struggled for decades to find the source of their ability to inhibit cancer cell growth.

7 Jul 2020

Research shows IQGAP1 as a common target in variants of triple negative breast cancer

The cover for issue 26 of Oncotarget features Figure 6, "Mislocalization of IQGAP1-BRCA1 in human TNBC tumors phenocopies the dominant mutants and the TNBC cells," by Osman, et al. and reported that IQGAP1 is a signaling scaffold implicated in TNBC, but its mechanism is unknown.

30 Jun 2020

Genes associated with SARS-CoV-2 human lung cell infection

Now, a new study published on the preprint server bioRxiv in June 2020 attempts to make sense of this data to identify viral genes that are explicitly expressed in the cells infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This could help reveal new therapeutic targets.

26 Jun 2020

Protein profile in serum reflects COVID-19 severity

The wide range of manifestations of COVID-19 has continued to baffle investigators. Now, a new study published on the preprint server medRxiv in June 2020 shows that blood proteins in COVID-19 patients change over time, and these can possibly predict or reflect the severity of disease. More, they may present targets for treatment.

25 Jun 2020

Novel treatment provides cardioprotection after heart attack in animal models

A novel treatment reduces heart damage after serious heart attacks in two animal models. Injections of two chemicals in a slow-release form significantly reduced the size of the dead heart tissue, known as the infarct, and improved the function of the left ventricle, as compared to untreated subjects.

23 Jun 2020

USC researchers unlock fatal vulnerability in many cancer cells

Like any cells in the body, cancer cells need sugar - namely glucose - to fuel cell proliferation and growth.

17 Jun 2020

Combination of antibodies and internal radiation can help fight cervical cancer

The sugar coating on cancer cells helps them thrive, and a new study indicates patients with cervical cancer who make antibodies to those sugars appear to do better when they also receive internal radiation therapy.

16 Jun 2020