Protein C News and Research

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One-time CRISPR therapy safely lowers cholesterol and triglycerides in early trial

In a 15-patient, Phase 1 one, first-in-human trial, a one-time, CRISPR-Cas9 gene-editing therapy safely reduced LDL cholesterol and triglycerides in people with difficult-to-treat lipid disorders, according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

10 Nov 2025

Daily oral medication matches injectable therapies in reducing bad cholesterol

Among people with a previous heart attack or stroke, or who are at high risk for one, a daily oral medication may offer an effective alternative to injections of PCSK9 inhibitors to lower low-density lipoprotein (LDL or "bad" cholesterol), according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

10 Nov 2025

Weill Cornell scientists discover early step in fat cell inflammation leading to diabetes

Weill Cornell Medicine investigators have identified an early step in a cellular process that leads to inflammation in fat cells and may result in type 2 diabetes in people with obesity.

10 Nov 2025

Uppsala researchers develop Trojan horse approach for medulloblastoma treatment

The malignant pediatric brain tumor medulloblastoma is driven by proteins deep within the cancer cells, for which there are often no effective drugs available.

10 Nov 2025

New dietary supplement may efficiently treat iron deficiency and anemia

Iron deficiency is globally widespread. Women are particularly affected, with one in five in Europe suffering from iron deficiency.

10 Nov 2025

Abselion launches His-Tagged Protein Quantification Kit and Sensors for Amperia at PEGS Europe 2025

Abselion, a pioneering life sciences technology company focused on simplifying biomolecule quantification, has expanded its Amperia™ assay portfolio with the launch of its Tagged Protein Quantification Kit | His-tag and Tagged Protein Sensor | His-tag Quantification.

10 Nov 2025

Do dietary supplements really improve muscle health in non-athletes?

Dietary supplements can support muscle health, but their effectiveness varies. This review explores their role in physical activity and age-related muscle loss.

10 Nov 2025

Maternal type 1 diabetes may protect children from developing the disease

Findings suggest maternal T1D exposure leads to protective epigenetic alterations in children, influencing immune response and type 1 diabetes susceptibility.

10 Nov 2025

Drinking orange juice daily may fine-tune genes tied to cardiovascular wellness

Regular orange juice consumption reprograms immune-cell gene activity linked to blood pressure, lipid metabolism, and inflammation in healthy adults. The molecular effects differ by body weight, suggesting BMI-tailored benefits from this everyday beverage.

9 Nov 2025

Studies uncover two novel, critical strategies for bacterial surface movement

New studies from Arizona State University reveal surprising ways bacteria can move without their flagella - the slender, whip-like propellers that usually drive them forward.

8 Nov 2025

SGLT2 inhibitors show consistent cardio-renal protection in 70,000 patients

In late-breaking presentations at the American Society of Nephrology Kidney Week meeting and simultaneously published in two companion papers in JAMA, the findings are based on data from over 70,000 participants across 10 major randomised controlled trials. The meta-analyses were conducted by the SGLT2 Inhibitor Meta-analysis Cardio-Renal Trialists' Consortium (SMART-C), led by The George Institute for Global Health.

7 Nov 2025

Study links father's resilience to better prenatal health outcomes

A husband's optimism and confidence may play a crucial, if often unseen, role in helping babies arrive healthy and on time.

7 Nov 2025

Protein linked to cancer plays key role in wound healing

When doctors detect elevated levels of SerpinB3 in a blood test, it can signal that something is seriously wrong, from hard-to-treat cancers to severe inflammatory conditions.

7 Nov 2025

Mismatch in kidney tests may reveal hidden health risks

A mismatch between two common tests for kidney function may indicate a higher risk for kidney failure, heart disease, and death, a new study shows.

7 Nov 2025

New molecule offers a promising avenue to treat triple-negative breast cancer

A new molecule developed by researchers at Oregon Health & Science University offers a promising avenue to treat intractable cases of triple-negative breast cancer - a form of cancer that is notoriously aggressive and lacks effective treatments.

7 Nov 2025

Multiple protein forms from a single gene offer fresh insight into rare disease mechanisms

Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients through a collaboration with Boston Children's Hospital.

7 Nov 2025

Rockefeller scientists engineer next-generation antibody to replace IVIG therapy

Intravenous immunoglobulin (IVIG) therapy involves infusing patients with naturally occurring IgG antibodies to treat autoimmune conditions.

7 Nov 2025

New insights reveal how TCF and LEF proteins control Wnt signaling and disease progression

Researchers have unveiled the intricate molecular mechanisms governing TCF/LEF-mediated transcription in the canonical Wnt pathway, identifying these proteins as promising therapeutic targets for cancer and fibrotic diseases.

7 Nov 2025

Study reveals structural and cellular clues behind cancer-linked GnT-V enzyme selectivity

Glycans are important complex carbohydrates found on cell surfaces that serve crucial roles in cell-to-cell communication, structure, and protection.

7 Nov 2025

Scientists uncover mechanism driving efficient protein deacetylation by Sir2 enzyme

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation cycle of the Sir2 enzyme, reveal researchers from Science Tokyo.

7 Nov 2025

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Protein C News and Research

One-time CRISPR therapy safely lowers cholesterol and triglycerides in early trial

Daily oral medication matches injectable therapies in reducing bad cholesterol

Weill Cornell scientists discover early step in fat cell inflammation leading to diabetes

Uppsala researchers develop Trojan horse approach for medulloblastoma treatment

New dietary supplement may efficiently treat iron deficiency and anemia

Abselion launches His-Tagged Protein Quantification Kit and Sensors for Amperia at PEGS Europe 2025

Do dietary supplements really improve muscle health in non-athletes?

Maternal type 1 diabetes may protect children from developing the disease

Drinking orange juice daily may fine-tune genes tied to cardiovascular wellness

Studies uncover two novel, critical strategies for bacterial surface movement

SGLT2 inhibitors show consistent cardio-renal protection in 70,000 patients

Study links father's resilience to better prenatal health outcomes

Protein linked to cancer plays key role in wound healing

Mismatch in kidney tests may reveal hidden health risks

New molecule offers a promising avenue to treat triple-negative breast cancer

Multiple protein forms from a single gene offer fresh insight into rare disease mechanisms

Rockefeller scientists engineer next-generation antibody to replace IVIG therapy

New insights reveal how TCF and LEF proteins control Wnt signaling and disease progression

Study reveals structural and cellular clues behind cancer-linked GnT-V enzyme selectivity

Scientists uncover mechanism driving efficient protein deacetylation by Sir2 enzyme

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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