Preclinical News and Research

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Aravive Biologics gains Fast Track Designation for AVB-S6-500 from U.S. FDA

Aravive Biologics, Inc. announced today that the U.S. Food and Drug Administration has granted Fast Track Designation to AVB-S6-500 as a potential treatment for platinum-resistant recurrent ovarian cancer.

20 Aug 2018

GBCA creates model for developing scientist-advocate collaborations in cancer research

At Georgetown Lombardi Comprehensive Cancer Center, a group of breast cancer advocates say they've created a model for developing productive, successful, and sustainable collaborations between advocates and scientists in cancer research. They describe their efforts in an article published online August 17 in the journal Cancer Research.

20 Aug 2018

Study offers possibility of squelching a focal epilepsy seizure before symptoms appear

Patients with focal epilepsy that does not respond to medications badly need alternative treatments.

17 Aug 2018

Ology Bioservices wins $8.4 million worth agreement to manufacture anti-Ebola monoclonal antibody

Ology Bioservices, Inc., a biologics contract development and manufacturing organization, announced today that it was awarded an Other Transaction Agreement to support the Joint Project Manager Medical Countermeasure Systems, a component of the Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense for advanced biologics manufacturing services—specifically, to manufacture an anti-Ebola monoclonal antibody.

17 Aug 2018

Researchers describe promising strategy to remove melanoma's most powerful defenses

Immunotherapies use the immune system to fight cancer. But cancers like melanoma have found ways to turn off the immune system, allowing them to resist treatments and often leading to recurrence.

16 Aug 2018

A class of proteins shown to be effective in reducing drug-seeking behaviors

A class of proteins that has generated significant interest for its potential to treat diseases, has for the first time, been shown to be effective in reducing relapse, or drug-seeking behaviors, in a preclinical study.

14 Aug 2018

New strategy accelerates, automates process of prototype molecule optimization

The search for new medicinal molecules with predetermined properties is a rather complex, expensive and time-consuming process, especially in oncology.

14 Aug 2018

Scientists uncover mechanisms responsible for development of fibrosis

Idiopathic pulmonary fibrosis is an incurable lung disease of unknown origin with limited treatment options. Research suggests that the signaling molecule WNT5A plays a key role in the pathogenic process.

10 Aug 2018

New laboratory-synthesized molecule appears to fight malaria effectively

A novel laboratory-synthesized molecule based in natural compounds found in marine gliding bacteria - known as marinoquinolines - is a strong candidate for the development of a new antimalarial drug.

10 Aug 2018

Cleveland Clinic awarded $4.7 million grant to study prevention of cancer-associated blood clots

The National Heart, Lung and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $4.7 million grant to Cleveland Clinic to study the prevention of life-threatening, cancer-associated blood clots.

9 Aug 2018

Researchers develop and test new MRI coil for preclinical studies

Researchers from ITMO University developed and tested an MRI coil providing high-resolution imaging of the whole body of a mouse.

9 Aug 2018

New findings pave way for novel, improved drugs to treat psychiatric disorders

Researchers at Columbia University Irving Medical Center have found new evidence of how certain transport proteins are working at the molecular level, paving the way for new, improved drugs to treat psychiatric disorders.

9 Aug 2018

Scientists identify drug that could reverse pulmonary arterial hypertension

Scientists at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago took a major step toward developing a new treatment for pulmonary arterial hypertension, a severe lung disease with a five-year survival rate of 50 percent.

9 Aug 2018

Researchers develop drug-delivery system that allows rapid response to heart attacks

Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed a drug-delivery system that allows rapid response to heart attacks without surgical intervention.

7 Aug 2018

Scientists create unique polymeric materials to repair traumatized human organs

Tissue engineering is the future of medicine. Under Project 5-100, the Polymer Materials for Tissue Engineering and Transplantology Laboratory of Peter the Great St. Petersburg Polytechnic University created unique polymeric materials for medical purposes that repair traumatized human organs.

7 Aug 2018

Cocaine relapse is reduced in preclinical model with BDNF administration

Cocaine relapse was significantly reduced in a preclinical model when brain-derived neurotropic factor was applied to the nucleus accumbens deep in the brain immediately before cocaine-seeking behavior, report investigators at the Medical University of South Carolina in an article published online in June 2018 by Addiction Biology.

3 Aug 2018

Regenacy Pharmaceuticals partners with CMTA to advance ricolinostat for treating hereditary neuropathy

Regenacy Pharmaceuticals, LLC, a clinical-stage biopharmaceutical company developing breakthrough treatments for diabetic and other peripheral neuropathies, today announced a collaboration with the Charcot-Marie-Tooth Association, a registered non-profit organization serving the hereditary neuropathy patient community, to validate the role of HDAC6 in multiple forms of Charcot-Marie-Tooth disease and evaluate the efficacy of ricolinostat, a selective HDAC6 inhibitor, in animal models.

2 Aug 2018

Tumor suppressor gene PTEN may be potential Achilles heel for breast cancer cells

In an article published July 17, 2018 by Nature Communications, a highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report that normal breast cells can prevent successful radiation treatment of breast cancer due to dysregulation between tumor suppressors and oncogenes.

2 Aug 2018

Researchers discover key piece for slowing colorectal cancer subtype

Inhibiting the Jagged 1 protein in mice prevents the proliferation and growth of colon and rectal tumors. What is more, this approach to the disease permits the removal of existing tumors.

2 Aug 2018

New treatment may be on the horizon for Parkinson's disease

More of us are susceptible to Parkinson's as we age, as evidenced by actor Alan Alda's recent diagnosis. A new treatment may be on the horizon.

2 Aug 2018

Preclinical News and Research

Aravive Biologics gains Fast Track Designation for AVB-S6-500 from U.S. FDA

GBCA creates model for developing scientist-advocate collaborations in cancer research

Study offers possibility of squelching a focal epilepsy seizure before symptoms appear

Ology Bioservices wins $8.4 million worth agreement to manufacture anti-Ebola monoclonal antibody

Researchers describe promising strategy to remove melanoma's most powerful defenses

A class of proteins shown to be effective in reducing drug-seeking behaviors

New strategy accelerates, automates process of prototype molecule optimization

Scientists uncover mechanisms responsible for development of fibrosis

New laboratory-synthesized molecule appears to fight malaria effectively

Cleveland Clinic awarded $4.7 million grant to study prevention of cancer-associated blood clots

Researchers develop and test new MRI coil for preclinical studies

New findings pave way for novel, improved drugs to treat psychiatric disorders

Scientists identify drug that could reverse pulmonary arterial hypertension

Researchers develop drug-delivery system that allows rapid response to heart attacks

Scientists create unique polymeric materials to repair traumatized human organs

Cocaine relapse is reduced in preclinical model with BDNF administration

Regenacy Pharmaceuticals partners with CMTA to advance ricolinostat for treating hereditary neuropathy

Tumor suppressor gene PTEN may be potential Achilles heel for breast cancer cells

Researchers discover key piece for slowing colorectal cancer subtype

New treatment may be on the horizon for Parkinson's disease

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