Sclerosis News and Research

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Viewpoints: Playing chicken on entitlements; 'Getting serious' about mental illness; Hospital labs devastated by Sandy

This is no time for a Grand Bargain, because the Republican Party, as now constituted, is just not an entity with which the president can make a serious deal. If we're going to get a grip on our nation's problems - of which the budget deficit is a minor part - the power of the G.O.P.'s extremists, and their willingness to hold the economy hostage if they don't get their way, needs to be broken. And somehow I don't think that's going to happen in the next few days (Paul Krugman, 12/20).

21 Dec 2012

FUS RNA binding ability essential for development of Amyotrophic Lateral Sclerosis

Research led by Dr. Udai Pandey, Assistant Professor of Genetics at LSU Health Sciences Center New Orleans, has found that the ability of a protein made by a gene called FUS to bind to RNA is essential to the development of Amyotrophic Lateral Sclerosis (ALS). This discovery identifies a possible therapeutic target for the fatal neurological disease.

20 Dec 2012

Scientists uncover TDP-43 protein as possible target for treatment of ALS, FTD

Neuroscientists at Georgetown University Medical Center say they have new evidence that challenges scientific dogma involving two fatal neurodegenerative diseases - amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD) - and, in the process, have uncovered a possible therapeutic target as a novel strategy to treat both disorders.

20 Dec 2012

Lou Gehrig's disease may be treatable using neural stem cells

Promising new research provides evidence that ALS, amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, may be treatable using neural stem cells.

20 Dec 2012

Lymphocyte clue to multiple sclerosis drug response

Patients with rapid recovery of CD4-positive T cells after alemtuzumab treatment for multiple sclerosis are at risk for disease progression or relapse, research suggests.

18 Dec 2012

BubR1 and its associated regulators promising targets for aging disorders and cancer

A new series of studies in mouse models by Mayo Clinic researchers uncovered that the aging process is characterized by high rates of whole-chromosome losses and gains in various organs, including heart, muscle, kidney and eye, and demonstrate that reducing these rates slows age-related tissue deterioration and promotes a healthier life span. The findings appear in today's online issue of Nature Cell Biology.

18 Dec 2012

Fingolimod associated with modest, rapid increase in macular volume

Patients with multiple sclerosis treated with fingolimod undergo a modest but rapid increase in macular volume, research shows.

13 Dec 2012

Patients with multiple sclerosis have low levels of Egr2/3 protein in T lymphocytes

Researchers from Queen Mary, University of London have discovered that two proteins which are believed to play a key role in controlling the body's immune response are found in lower levels in T lymphocytes from patients with multiple sclerosis (MS).

13 Dec 2012

Lack of TDP-43 protein can lead to frontotemporal dementia/ALS

Researchers at Mayo Clinic in Florida have uncovered a toxic cellular process by which a protein that maintains the health of neurons becomes deficient and can lead to dementia.

11 Dec 2012

FoxP3 gene expression identifies ALS disease progression in 80% of patients

The debilitating symptoms of amyotrophic lateral sclerosis, or ALS, appear to be increased by a lack of inflammation-reducing T cells, report scientists from the Methodist Neurological Institute in an upcoming print issue of The EMBO Molecular Medicine Journal.

10 Dec 2012

Kessler Foundation to study effects of intellectual enrichment on cognitive decline in people with MS

The National Multiple Sclerosis (MS) Society awarded Victoria Leavitt, Ph.D., a $44,000 grant to study the effects of intellectual enrichment on cognitive decline in individual with multiple sclerosis.

7 Dec 2012

RedHill Biopharma completes $6.5M private placement

RedHill Biopharma Ltd., an Israeli biopharmaceutical company focusing primarily on development and acquisition of late clinical stage, patent-protected, new formulations and combinations of existing drugs, reported the completion of a private placement in a total amount of approximately $6.5 million.

6 Dec 2012

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

Despite researchers' best efforts, no drug exists that can slow, halt or reverse the onslaught of Alzheimer's disease. A progressive and fatal neurodegenerative disorder, Alzheimer's has stolen the memories and livelihoods of millions-leaving patients and their families struggling to cope with the disease's devastating consequences. But today, scientists at the Gladstone Institutes propose a new research avenue that has the potential to change all that.

6 Dec 2012

Scientists develop MitoFish for in vivo studies of mitochondria transport in nerve cells

Scientists have demonstrated a new way to investigate mechanisms at work in Alzheimer's and other neurodegenerative diseases, which also could prove useful in the search for effective drugs. For new insights, they turned to the zebrafish, which is transparent in the early stages of its life. The researchers developed a transgenic variety, the "MitoFish," that enables them to see - within individual neurons of living animals - how brain diseases disturb the transport of mitochondria, the power plants of the cell.

6 Dec 2012

Vitamin D and women’s risk for multiple sclerosis

Women who have high vitamin D levels are at a decreased risk for developing multiple sclerosis, shows research.

5 Dec 2012

UK and U.S.researchers collaborate to determine long-term outcomes of children with epilepsy

In the first study of its kind, researchers from five institutions from the UK and U.S. collaborating to determine the long-term outcomes of children with epilepsy found that outcomes varied despite similar short-term morbidity among the originally surveyed children when they were followed up within 10 years post-occurrence.

4 Dec 2012

New laser surgical technique appears to be safe and effective in treating epilepsy

A developing new laser surgical technique for epilepsy appears to be safe and effective and reduces hospital stays to one or two days, according to two research reports presented today during the American Epilepsy Society 66th Annual Meting at the San Diego Convention Center.

3 Dec 2012

Reduced production of myelin may play role in development of mental illness: Study

Reduced production of myelin, a type of protective nerve fiber that is lost in diseases like multiple sclerosis, may also play a role in the development of mental illness, according to researchers at the Graduate School of Biomedical Sciences at Mount Sinai School of Medicine.

1 Dec 2012

Scientists identify two genes involved in establishing neuronal circuits required for breathing

Scientists at NYU Langone Medical Center have identified two genes involved in establishing the neuronal circuits required for breathing. They report their findings in a study published in the December issue of Nature Neuroscience.

30 Nov 2012

German Research Foundation to establish new CRC at Mainz University Medical Center

On January 1, 2013, the German Research Foundation (DFG) will establish a new Collaborative Research Center (CRC) at the University Medical Center of Johannes Gutenberg University Mainz (JGU).

30 Nov 2012

Sclerosis News and Research

Viewpoints: Playing chicken on entitlements; 'Getting serious' about mental illness; Hospital labs devastated by Sandy

FUS RNA binding ability essential for development of Amyotrophic Lateral Sclerosis

Scientists uncover TDP-43 protein as possible target for treatment of ALS, FTD

Lou Gehrig's disease may be treatable using neural stem cells

Lymphocyte clue to multiple sclerosis drug response

BubR1 and its associated regulators promising targets for aging disorders and cancer

Fingolimod associated with modest, rapid increase in macular volume

Patients with multiple sclerosis have low levels of Egr2/3 protein in T lymphocytes

Lack of TDP-43 protein can lead to frontotemporal dementia/ALS

FoxP3 gene expression identifies ALS disease progression in 80% of patients

Kessler Foundation to study effects of intellectual enrichment on cognitive decline in people with MS

RedHill Biopharma completes $6.5M private placement

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

Scientists develop MitoFish for in vivo studies of mitochondria transport in nerve cells

Vitamin D and women’s risk for multiple sclerosis

UK and U.S.researchers collaborate to determine long-term outcomes of children with epilepsy

New laser surgical technique appears to be safe and effective in treating epilepsy

Reduced production of myelin may play role in development of mental illness: Study

Scientists identify two genes involved in establishing neuronal circuits required for breathing

German Research Foundation to establish new CRC at Mainz University Medical Center

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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