Preclinical News and Research

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Researchers use guide RNAs to improve base editing system

Researchers have used guide RNAs to improve the adenine base editing (ABE) system, used by scientists to alter genetic codes in animal models of disease.

1 Aug 2018

Gene linked to hair loss could be exploited to improve cancer immunotherapy

A gene that's associated with an autoimmune form of hair loss could be exploited to improve cancer immunotherapy, suggests a new mouse study by Columbia University Irving Medical Center (CUIMC) researchers.

31 Jul 2018

UCI receives $9 million grant to find long-term impact of cannabis exposure on adolescent brain

The National Institute on Drug Abuse, part of the National Institutes of Health, has awarded the University of California, Irvine School of Medicine, a 4-year, $9 million grant aimed at determining the long-term impact of cannabis exposure on the adolescent brain.

30 Jul 2018

Researchers investigate new treatment that is effective against recurrent breast cancers

What do one in five breast cancers have in common? Large amounts of a protein called HER2 (or human epidermal growth factor receptor 2).

30 Jul 2018

DFG to honor two researchers with Ursula M. Händel Animal Welfare Prize

Prof. Dr. Ellen Fritsche, a toxicologist from the Leibniz Research Institute for Environmental Medicine at Heinrich Heine University Düsseldorf, and PD Dr. Dr. Hamid Reza Noori, a mathematician, physicist and medical scientist from the Max Planck Institute for Biological Cybernetics in Tübingen, are to be presented with the Ursula M. Händel Animal Welfare Prize by the Deutsche Forschungsgemeinschaft.

27 Jul 2018

Experts describe role of quantitative systems pharmacology in first-in-human clinical trials

Certara, the global leader in model-informed drug development, regulatory science, market access and real-world evidence services, announced today that Clinical Pharmacology & Therapeutics has published its "Letter to the Editor" describing the important role that quantitative systems pharmacology can play in defining dosing criteria for first-in-human clinical trials, together with the European Medicines Agency's response.

26 Jul 2018

New mouse model shows great promise for Rett syndrome research

In an article released today from Jeannie T. Lee, MD PhD of Massachusetts General Hospital, there is hope on the horizon for future research specific to Rett syndrome, a rare childhood neurodevelopmental disorder.

26 Jul 2018

Omeros’ OMS721 receives positive opinion from EMA's COMP for treating hematopoietic stem cell transplant

Omeros Corporation announced today that the European Medicines Agency's Committee for Orphan Medicinal Products issued a positive opinion recommending orphan drug designation of OMS721 for treatment in hematopoietic stem cell transplantation.

25 Jul 2018

MODEL-AD Center releases eight new mouse models for Alzheimer's research

The MODEL-AD Center, an ambitious project to develop and distribute precise mouse models of late-onset Alzheimer's disease (AD), has released eight new models carrying genetic mutations found in patients.

23 Jul 2018

Sage launches new web-based tool that helps explore curated genomic analyses of Alzheimer's

Sage Bionetworks announces the launch of the Agora platform an interactive, web-based tool that allows researchers to explore curated genomic analyses of Alzheimer's Disease, including a list of early candidate target nominations for AD.

20 Jul 2018

PureTech Health collaborates with Roche to advance oral administration of antisense oligonucleotides

PureTech Health plc, a clinical-stage biopharmaceutical company developing novel medicines focused on the Brain-Immune-Gut Axis, today announced that it has entered into a multiyear collaboration with F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc., to advance PureTech's milk-derived exosome platform technology for the oral administration of Roche's antisense oligonucleotide platform.

20 Jul 2018

Study: Binge drinking impairs working memory in adolescent brain

A new study from researchers at Columbia University Irving Medical Center found that binge drinking impairs working memory in the adolescent brain. The study, in mice, explains why teenagers who binge drink are 15 times more likely to become alcoholics during adulthood.

19 Jul 2018

Kite collaborates with Gadeta to develop novel gamma delta TCR therapies for various cancers

Kite, a Gilead Company, and Gadeta B.V., a privately-held company focused on the discovery and development of novel cancer immunotherapies based on gamma delta T cell receptors, have entered into a strategic collaboration to develop novel gamma delta TCR therapies in various cancers.

19 Jul 2018

New review examines cannabinoids' potential for direct treatment of cancer

Previous research has shown that cannabinoids can help lessen side effects of anti-cancer therapies. Now a new British Journal of Pharmacology review has examined their potential for the direct treatment of cancer.

18 Jul 2018

Inflection Biosciences' dual mechanism inhibitor shows promise as treatment for CLL

Inflection Biosciences Ltd, a private company developing innovative therapeutics for cancer, today announced the publication of preclinical data showing the company's dual mechanism PIM/PI3 kinase inhibitor IBL-202 has promise as a treatment for chronic lymphocytic leukemia.

17 Jul 2018

MR Solutions’ 7T MRI imaging system installed at University of Hawaii

MR Solutions has installed Hawaii’s first preclinical cryogen-free MRI imaging system to help researchers improve the rate of kidney disease detection through research.

From MR Solutions 17 Jul 2018

Can-Fite BioPharma receives Australian and Chinese patents for new drug to treat erectile dysfunction

Can-Fite BioPharma Ltd., a biotechnology company advancing a pipeline of proprietary small molecule drugs that address liver diseases, inflammatory diseases and sexual dysfunction, today announced that the Australian and Chinese patent offices have granted the Company a patent for the utilization of A3 adenosine receptor ligands in the treatment of sexual dysfunction, in a patent (Australian, No. 2013301125ZL, Chinese No. 2013800472970) titled, "A3 adenosine receptor ligands for use in treatment of a sexual dysfunction."

17 Jul 2018

Researchers reduce size of tumors in mice by artificially activating the brain's reward system

By artificially activating the brain's reward system, researchers at the Technion-Israel Institute of Technology have dramatically reduced the size of cancerous tumors in mice. The findings were published recently in the journal Nature Communications.

16 Jul 2018

Researchers develop nanostructured surface to accelerate wound healing after dental implants

Vasodilating stents, "labs-on-chips" for analysis on smallest areas, 3D cell culturing systems for tissue reconstruction: microtechnology is gaining importance in the medical sector. It also opens up new potentials in the area of implantology.

16 Jul 2018

Traumatic brain injury biomarker could help predict patient prognosis

A preclinical study has shown that levels of lysophosphatidic acid (LPA) are significantly increased following traumatic brain injury (TBI).

16 Jul 2018

Preclinical News and Research

Researchers use guide RNAs to improve base editing system

Gene linked to hair loss could be exploited to improve cancer immunotherapy

UCI receives $9 million grant to find long-term impact of cannabis exposure on adolescent brain

Researchers investigate new treatment that is effective against recurrent breast cancers

DFG to honor two researchers with Ursula M. Händel Animal Welfare Prize

Experts describe role of quantitative systems pharmacology in first-in-human clinical trials

New mouse model shows great promise for Rett syndrome research

Omeros’ OMS721 receives positive opinion from EMA's COMP for treating hematopoietic stem cell transplant

MODEL-AD Center releases eight new mouse models for Alzheimer's research

Sage launches new web-based tool that helps explore curated genomic analyses of Alzheimer's

PureTech Health collaborates with Roche to advance oral administration of antisense oligonucleotides

Study: Binge drinking impairs working memory in adolescent brain

Kite collaborates with Gadeta to develop novel gamma delta TCR therapies for various cancers

New review examines cannabinoids' potential for direct treatment of cancer

Inflection Biosciences' dual mechanism inhibitor shows promise as treatment for CLL

MR Solutions’ 7T MRI imaging system installed at University of Hawaii

Can-Fite BioPharma receives Australian and Chinese patents for new drug to treat erectile dysfunction

Researchers reduce size of tumors in mice by artificially activating the brain's reward system

Researchers develop nanostructured surface to accelerate wound healing after dental implants

Traumatic brain injury biomarker could help predict patient prognosis

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