Preclinical News and Research

RSS

Molecules formed when the body metabolizes omega-3 fatty acids may inhibit cancer

A class of molecules formed when the body metabolizes omega-3 fatty acids could inhibit cancer's growth and spread, University of Illinois researchers report in a new study in mice.

16 Jul 2018

Fruit fly research leads to potential drug for debilitating diseases caused by parasitic worms

River blindness and elephantiasis are debilitating diseases caused by parasitic worms that infect as many as 150 million people worldwide.

13 Jul 2018

Researchers identify new region in mouse brain that affects appetite and body weight

Researchers at A*STAR's Singapore Bioimaging Consortium have identified a new region of the mouse brain called the Tuberal Nucleus, which affects appetite and body weight

13 Jul 2018

New technique measures how well cancer drugs reach their targets

Scientists have developed a technique that allows them to measure how well cancer drugs reach their targets inside the body.

13 Jul 2018

Sodium nitroprusside treatment prevents schizophrenia symptoms in animal model

Researchers at the Federal University of São Paulo in Brazil have tested a treatment with sodium nitroprusside in a strain of rats that spontaneously develop some of the symptoms associated with schizophrenia.

12 Jul 2018

Fighting cancer with engineered cancer cells

Researchers at Brigham and Women's Hospital have engineered cancer cells that track and kill cancer cells. The modified cancer cells have demonstrated anti-cancer efficacy in preclinical studies, destroying both primary and metastatic tumours.

12 Jul 2018

Clinical trial examines impact of high-dose omega-3 and vitamin D on halting type 1 diabetes

Scientists from the Diabetes Research Institute at the University of Miami Miller School of Medicine today announced the launch of a new clinical trial that will assess the impact of high-dose omega-3 fatty acids and vitamin D supplementation on halting the progression of type 1 diabetes.

12 Jul 2018

New clinical trial to evaluate virotherapy and immunotherapy combination for ovarian, colorectal cancers

Ludwig Cancer Research and the Cancer Research Institute announce the initiation of a clinical trial to evaluate the combination of ONCOS-102, an experimental anti-tumor virotherapy, with the checkpoint blockade antibody IMFINZI (durvalumab) for advanced ovarian and colorectal cancers.

12 Jul 2018

Researchers elucidate role of mutations in deadly brain cancer

Researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have discovered how different mutations in a specific gene help drive glioblastoma, the most lethal form of brain cancer.

11 Jul 2018

Researchers develop biofilm formulations that protect from necrotizing enterocolitis

Most of the time, we think biofilms are bad news. And when pathogenic microbes form biofilms, they are.

11 Jul 2018

Cleara Biotech creates three public-private partnerships to discover and develop new therapeutics

Cleara Biotech B.V., a Netherlands-based biopharmaceutical company, announced today the creation of three public-private partnerships to discover and develop new therapeutics.

6 Jul 2018

Seeing the Unexpected: Regulatory T Cells and Basophils

Dr. Jagadeesh Bayry from INSERM discusses his recent research in the field of immunology, and how T regulatory cells activate, rather than suppress, basophils.

4 Jul 2018

U.S. researchers recommend development of anti-cancer drugs based on mechanism of Namodenoson

Can-Fite BioPharma Ltd., a biotechnology company advancing a pipeline of proprietary small molecule drugs that address cancer, liver and inflammatory diseases, today announced that U.S. researchers published scientific findings recommending development of anti-Liver Cancer Drugs based on a mechanism of action utilized by Namodenoson.

2 Jul 2018

Streamlining and translating basic science discoveries into the clinic

To make sure that good ideas to enhance healthcare are not lost due to a lack of resources, a growing number of centers at Penn Medicine organize forums to pitch ideas to improve medical devices and technology, hold annual competitions to fund studies to improve patient care while keeping costs down, and sponsor seed grants for programs focused on patients who need individualized tailoring of their treatment.

2 Jul 2018

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

The California Institute for Regenerative Medicine board has awarded City of Hope $3.7 million to develop a phase 1 clinical trial for glioblastoma patients that will genetically engineer their stem cells to better tolerate chemotherapy's side effects, allowing them to receive higher doses of the therapy.

30 Jun 2018

Even mild sleep disturbances can increase blood pressure in women

It is well known that chronic sleep deprivation can affect cardiovascular health. But according to a new study from Columbia University Irving Medical Center, even mild sleep problems, such as having trouble falling asleep, can raise blood pressure in women.

27 Jun 2018

Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

In preclinical experiments, Laurie Harrington, Ph.D., and colleagues at the University of Alabama at Birmingham have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease.

27 Jun 2018

Phase 1 clinical trial of poliovirus therapy shows long-term survival benefit for recurrent glioblastoma

A genetically modified poliovirus therapy developed at Duke Cancer Institute shows significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent in a phase 1 clinical trial.

26 Jun 2018

MILabs announces innovative PET imaging features in its new VECTor6 system

The new VECTor6 imaging system is packed with exclusive preclinical PET imaging features including 0.6 mm 18F resolution, the elimination of positron-range blurring for e.g. 124I, simultaneous multi-isotope PET and PET/SPECT tomography, and α- and β-radiotherapy imaging.

26 Jun 2018

Unbiased approach reveals how to restore breast cancer drugs’ tumor-killing potential

More than 60 percent of breast cancer cases involve defects in the same biochemical chain of events within cancer cells-- known as the PI3 kinase (PI3K) pathway--but efforts to develop therapies targeting this pathway have met with little success after hundreds of mostly failed clinical trials. And researchers still don't understand why.

26 Jun 2018

Preclinical News and Research

Molecules formed when the body metabolizes omega-3 fatty acids may inhibit cancer

Fruit fly research leads to potential drug for debilitating diseases caused by parasitic worms

Researchers identify new region in mouse brain that affects appetite and body weight

New technique measures how well cancer drugs reach their targets

Sodium nitroprusside treatment prevents schizophrenia symptoms in animal model

Fighting cancer with engineered cancer cells

Clinical trial examines impact of high-dose omega-3 and vitamin D on halting type 1 diabetes

New clinical trial to evaluate virotherapy and immunotherapy combination for ovarian, colorectal cancers

Researchers elucidate role of mutations in deadly brain cancer

Researchers develop biofilm formulations that protect from necrotizing enterocolitis

Cleara Biotech creates three public-private partnerships to discover and develop new therapeutics

Seeing the Unexpected: Regulatory T Cells and Basophils

U.S. researchers recommend development of anti-cancer drugs based on mechanism of Namodenoson

Streamlining and translating basic science discoveries into the clinic

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

Even mild sleep disturbances can increase blood pressure in women

Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

Phase 1 clinical trial of poliovirus therapy shows long-term survival benefit for recurrent glioblastoma

MILabs announces innovative PET imaging features in its new VECTor6 system

Unbiased approach reveals how to restore breast cancer drugs’ tumor-killing potential

Event guide: 4th LNP Formulation & Process Development Summit eBook

Latest eBooks

Editorial Focus eBook - Spatial and single-cell omics (1st edition)

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics