Transplant News and Research

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Tissue-engineered transplants safe and effective in the long term: Study

New results published in The Lancet today [Wednesday 23 October] reveal that five years after the first successful transplantation of a tissue-engineered airway (reported in The Lancet in 2008) the recipient continues to enjoy a good quality of life, and has not experienced any immunological complications or rejection of the implanted airway.

23 Oct 2013

Research: Low levels of vitamin D appear to increase child's risk of anemia

Low levels of the "sunshine" vitamin D appear to increase a child's risk of anemia, according to new research led by investigators at the Johns Hopkins Children's Center. The study, published online Oct. 10 in the Journal of Pediatrics, is believed to be the first one to extensively explore the link between the two conditions in children.

22 Oct 2013

New collaborative project aims to discover genes underlying rare genetic diseases

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21 Oct 2013

New study paves way for patient-specific regenerative therapies for inflammatory bowel diseases

A source of gut stem cells that can repair a type of inflammatory bowel disease when transplanted into mice has been identified by researchers at the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute at the University of Cambridge and at BRIC, the University of Copenhagen, Denmark.

18 Oct 2013

BWH, Case Western awarded $7.7M NIH grant to establish NHLBI National Sleep Research Resource

A $7.7 million grant from the National Institutes of Health to Brigham and Women's Hospital and Case Western Reserve University School of Medicine will establish the NHLBI National Sleep Research Resource, a comprehensive, easily accessible and well-annotated national repository of sleep data.

16 Oct 2013

NICE issues second draft guidance on PIXUVRI for treatment of aggressive B-cell NHL

Cell Therapeutics, Inc. today announced that the National Institute for Health and Care Excellence, a non-departmental public body of the Department of Health in the United Kingdom, issued second draft guidance on PIXUVRI (pixantrone) as a monotherapy for the treatment of adult patients with multiply relapsed or refractory aggressive B-cell non-Hodgkin lymphoma.

15 Oct 2013

Children who receive solid-organ transplants have risk of developing advanced kidney disease

Children who undergo transplants of solid organs have a high risk of developing advanced kidney disease, according to a new national study. Among these children, the highest risk is in those receiving lung or intestinal transplants, followed by heart and then liver transplants. The researchers say their findings reinforce the importance of continued screening of kidney function in pediatric transplant recipients.

14 Oct 2013

Scientists develop new method to create stem cells for human liver and pancreas

A new method for creating stem cells for the human liver and pancreas, which could enable both cell types to be grown in sufficient quantities for clinical use, has been developed by scientists.

11 Oct 2013

Scientists to combine NK cell therapy with immunocytokine to target childhood cancer

Researchers have made rapid advances in understanding how to manipulate the immune system safely to destroy cancer cells. Adoptive transfer of haploidentical natural killer cells has shown promise as a treatment option to target and kill cancer cells in a less toxic way than conventional therapies. Now for the first time, scientists will combine NK cell therapy with an immunocytokine to target children with relapsed/refractory disease including those with bulky tumors.

11 Oct 2013

Hispanics with kidney failure are less likely to receive kidney transplant due to living location

In the United States, Hispanics with kidney failure are less likely than non-Hispanic whites to receive a kidney transplant largely due to their blood type and because of where they live, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).

11 Oct 2013

Less educated, African Americans receive lower quality or marginal kidneys for transplantation

Among younger kidney transplant recipients, a disproportionate number of African Americans and individuals with less education receive organs that are of lower quality or are considered marginal, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The findings suggest that there are racial and social disparities in the allocation of transplanted organs that need to be addressed.

11 Oct 2013

Suppression of mitochondria: A dominant feature of diabetic kidney disease

Researchers at the University of California, San Diego School of Medicine have identified 13 metabolites - small molecules produced by cellular metabolism - that are significantly different in patients with diabetes and chronic kidney disease compared to healthy controls.

11 Oct 2013

Cleveland healthcare institutions receive $1M grant to develop Stroke Clinical Trials Coordinating Center

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11 Oct 2013

Liposorber LA-15 System to treat pediatric patients with primary FSGS gets FDA approval

The U.S. Food and Drug Administration today approved Liposorber LA-15 System to treat pediatric patients with primary focal segmental glomerulosclerosis either before transplant, or after renal (kidney) transplantation in which there is recurrence of FSGS.

11 Oct 2013

Combining gene therapy with stem cells leads to faster healing of burns

Johns Hopkins researchers, working with elderly mice, have determined that combining gene therapy with an extra boost of the same stem cells the body already uses to repair itself leads to faster healing of burns and greater blood flow to the site of the wound.

10 Oct 2013

Promedior starts Phase 2 clinical trial to evaluate PRM-151 in patients with myelofibrosis

Promedior, Inc., a clinical stage biotechnology company developing novel biologic therapeutics for the treatment of fibrosis, announced today that it has initiated a Phase 2 clinical trial to evaluate PRM-151, its lead product candidate, in patients with myelofibrosis.

10 Oct 2013

Compugen drug candidate prevents autoimmune type I diabetes in animal model

Compugen Ltd., announced today that CGEN-15001, an Fc fusion protein drug candidate derived from a novel immune checkpoint protein discovered by Compugen, has been shown to be highly efficient in preventing the development of disease in a well-accepted animal model of autoimmune type I diabetes, known also as juvenile diabetes.

9 Oct 2013

New method for improving cord blood transplant success

Starting with a discovery in zebrafish in 2007, Harvard Stem Cell Institute researchers have published initial results of a Phase Ib human clinical trial of a therapeutic that has the potential to improve the success of blood stem cell transplantation.

9 Oct 2013

New research identifies protein that controls formation of different types of mature blood cells

New research in the Journal of Experimental Medicine identifies a protein that controls the formation of different types of mature blood cells - a finding that could be important to developing new treatments for blood diseases and helping realize the potential of regenerative medicine.

8 Oct 2013

Kiadis Pharma signs Services Agreement with GRCBDS for Phase II clinical study with ATIR

Kiadis Pharma B.V., a clinical stage biopharmaceutical company developing treatments for blood cancers, announced today that a Services Agreement has been signed with the German Red Cross Blood Donor Service Baden-Wuerttemberg-Hessen (GRCBDS) whereby GRCBDS will provide pharmaceutical development and GMP manufacturing services for Kiadis Pharma's ongoing Phase II clinical study with ATIR™.

7 Oct 2013

Transplant News and Research

Tissue-engineered transplants safe and effective in the long term: Study

Research: Low levels of vitamin D appear to increase child's risk of anemia

New collaborative project aims to discover genes underlying rare genetic diseases

New study paves way for patient-specific regenerative therapies for inflammatory bowel diseases

BWH, Case Western awarded $7.7M NIH grant to establish NHLBI National Sleep Research Resource

NICE issues second draft guidance on PIXUVRI for treatment of aggressive B-cell NHL

Children who receive solid-organ transplants have risk of developing advanced kidney disease

Scientists develop new method to create stem cells for human liver and pancreas

Scientists to combine NK cell therapy with immunocytokine to target childhood cancer

Hispanics with kidney failure are less likely to receive kidney transplant due to living location

Less educated, African Americans receive lower quality or marginal kidneys for transplantation

Suppression of mitochondria: A dominant feature of diabetic kidney disease

Cleveland healthcare institutions receive $1M grant to develop Stroke Clinical Trials Coordinating Center

Liposorber LA-15 System to treat pediatric patients with primary FSGS gets FDA approval

Combining gene therapy with stem cells leads to faster healing of burns

Promedior starts Phase 2 clinical trial to evaluate PRM-151 in patients with myelofibrosis

Compugen drug candidate prevents autoimmune type I diabetes in animal model

New method for improving cord blood transplant success

New research identifies protein that controls formation of different types of mature blood cells

Kiadis Pharma signs Services Agreement with GRCBDS for Phase II clinical study with ATIR

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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