Preclinical News and Research

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Researchers create tool to determine patient's response to immunotherapy drugs

Understanding that not all bladder cancers are the same, researchers at the University of North Carolina Lineberger Comprehensive Cancer Center have created a tool that may help them to uncover why only a fraction of patients respond to new immune-based treatments.

21 May 2018

Rocket Pharma partners with Stanford University to advance FA and PKD gene therapy research

Rocket Pharmaceuticals, Inc., a leading U.S.-based multi-platform gene therapy company, and the Stanford University School of Medicine today announced a strategic collaboration to support the advancement of Fanconi Anemia and Pyruvate Kinase Deficiency gene therapy research.

17 May 2018

Doctors publish comprehensive proposal to ensure universal access to safe, affordable medications

The skyrocketing cost of prescription drugs is one of the biggest concerns for American voters. However, in his proposal last Friday, President Donald Trump failed to offer any new policies that would expand access, reduce costs, or increase the safety and efficacy of prescriptions.

17 May 2018

Alexo Therapeutics marks next significant milestone by initiating ALX148 combination cohorts

Alexo Therapeutics, a clinical-stage immuno-oncology company developing therapies to block the CD47 checkpoint mechanism, today announced it has initiated ALX148 combination dosing with targeted antibody therapies in its Phase 1 clinical program in patients with advanced solid tumors and lymphoma.

17 May 2018

Obsidian Therapeutics presents preclinical data on regulated IL12 and IL15 programs

Obsidian Therapeutics, Inc., a biotechnology company dedicated to the development of next-generation cell and gene therapies with pharmacologic operating systems, today announced that the company presented preclinical data on its regulated IL12 and IL15 programs at the Annual Meeting of the American Society of Gene and Cell Therapy in Chicago, IL.

17 May 2018

Researchers transplant retinal sheets derived from human embryonic stem cells in retinal degeneration mouse models

Researchers affiliated with the Kawasaki INnovation Gateway at SKYFRONT have developed new mouse models of retinal degeneration that enable transplantation of retinal sheets derived from human embryonic stem cells.

17 May 2018

Lowering blood cholesterol levels could enhance success of T-cell cancer immunotherapy

Cleveland Clinic researchers have demonstrated for the first time that lowering blood cholesterol levels could enhance the success of a specific type of T-cell immunotherapy in fighting cancer.

16 May 2018

Combination therapies targeting different cell types may be effective at treating colon cancer

Researchers in Germany have discovered that colon cancers are often resistant to existing drug treatments because they are composed of two different cell types that can replace each other when one cell type is killed.

16 May 2018

Tufts University, BioLabs announce the opening of new biotech facility for life sciences entrepreneurs

Tufts University and BioLabs today announced the opening of Tufts Launchpad | BioLabs, a full-service biotech facility supporting high-potential, early-stage life sciences startup ventures in the Boston area.

16 May 2018

New method generates detailed 3D images of the body's cancer cells

Making tumor cells glow: Medical physicists at Martin Luther University Halle-Wittenberg (MLU) have developed a new method that can generate detailed three-dimensional images of the body's interior.

16 May 2018

Study lays foundation for treating drug, alcohol addicts with noninvasive brain stimulation

In a study investigating the use of transcranial magnetic stimulation for drug addiction, researchers at Medical University of South Carolina are the first to demonstrate that the noninvasive brain stimulation technique can dampen brain activity in response to drug cues in chronic alcohol users and chronic cocaine users.

15 May 2018

Research suggests novel therapies to lower cardiovascular disease risk in rheumatoid arthritis patients

Preclinical and early clinical research conducted by teams at the University of Alabama at Birmingham and in Australia suggests that patients with rheumatoid arthritis could lower their risk of cardiovascular disease through cholesterol-lowering therapies, according to research published in the European Heart Journal.

15 May 2018

New drug reduces symptoms of Rett syndrome in preclinical models

A new article published in the Cell Reports describes how a new drug is able to reduce the symptoms and activate the dormant neurons characteristic of Rett Syndrome in preclinical models.

14 May 2018

LogicBio team to present data on preclinical effectiveness of GeneRide platform

LogicBio Therapeutics, Inc., a genetic medicine company founded to develop safe medicines with lasting therapeutic benefit for children with life-threatening diseases, today announced it will be presenting data on the company's technology and robust preclinical pipeline at the annual meeting of the American Society of Gene & Cell Therapy at the Hilton Chicago, from May 16-19, 2018.

14 May 2018

New study to explore link between diet, intestinal microbiota and cognitive decline

Are abnormal intestinal microorganisms a risk factor for developing cognitive impairment? Researchers at Rush University Medical Center are trying to answer that question with a new study that will explore how the intestinal microbiota – the bacteria in the intestine –influence the progression of cognitive decline and the development of Alzheimer's disease.

14 May 2018

Researchers identify serotonin receptor that could be targeted to boost memory

In a breakthrough that could one day help individuals with cognitive impairment, researchers at Columbia University Irving Medical Center identified a specific receptor related to the neurotransmitter serotonin that could be targeted with drugs to boost memory.

11 May 2018

Aravive Biologics demonstrates proof-of-mechanism for AVB-S6-500 in ongoing phase 1 study

Aravive Biologics, Inc. announced today that the company has demonstrated clinical proof-of-mechanism for AVB-S6-500 in neutralizing GAS6, based on analysis of the single ascending dose portion of the ongoing Phase 1 study.

10 May 2018

Columbia University Irving Medical Center and NewYork-Presbyterian launch new Mothers Center

In time for Mother's Day, NewYork-Presbyterian and Columbia University Irving Medical Center announced the opening of the Mothers Center, a new space that will provide comprehensive, multidisciplinary care before, during and after a high-risk pregnancy, starting later this month.

10 May 2018

Phase 2 study of dexpramipexole in hypereosinophilic syndromes meets its co-primary endpoints

Knopp Biosciences LLC today announced the publication of a report in the journal Blood that a Phase 2 study of dexpramipexole in hypereosinophilic syndromes met its co-primary endpoints.

10 May 2018

Newly developed technique allows researchers to study liver stage malaria

A newly developed technique allows researchers to more easily study malaria outside the human body during the earliest point of infection, the liver.

9 May 2018

Preclinical News and Research

Researchers create tool to determine patient's response to immunotherapy drugs

Rocket Pharma partners with Stanford University to advance FA and PKD gene therapy research

Doctors publish comprehensive proposal to ensure universal access to safe, affordable medications

Alexo Therapeutics marks next significant milestone by initiating ALX148 combination cohorts

Obsidian Therapeutics presents preclinical data on regulated IL12 and IL15 programs

Researchers transplant retinal sheets derived from human embryonic stem cells in retinal degeneration mouse models

Lowering blood cholesterol levels could enhance success of T-cell cancer immunotherapy

Combination therapies targeting different cell types may be effective at treating colon cancer

Tufts University, BioLabs announce the opening of new biotech facility for life sciences entrepreneurs

New method generates detailed 3D images of the body's cancer cells

Study lays foundation for treating drug, alcohol addicts with noninvasive brain stimulation

Research suggests novel therapies to lower cardiovascular disease risk in rheumatoid arthritis patients

New drug reduces symptoms of Rett syndrome in preclinical models

LogicBio team to present data on preclinical effectiveness of GeneRide platform

New study to explore link between diet, intestinal microbiota and cognitive decline

Researchers identify serotonin receptor that could be targeted to boost memory

Aravive Biologics demonstrates proof-of-mechanism for AVB-S6-500 in ongoing phase 1 study

Columbia University Irving Medical Center and NewYork-Presbyterian launch new Mothers Center

Phase 2 study of dexpramipexole in hypereosinophilic syndromes meets its co-primary endpoints

Newly developed technique allows researchers to study liver stage malaria

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