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Harnessing cell's natural delivery system for targeted drug delivery

Each cell in the body has its own unique delivery system that scientists are working on harnessing to move revolutionary biological drugs - molecules like proteins, RNA and combinations of the two - to specific diseased parts of the body.

17 Jul 2024

Semaglutide shows no higher 12-month risk of adverse neuropsychiatric outcomes than other antidiabetic drugs, study suggests

Researchers evaluated the 12-month neurological and psychiatric outcomes of semaglutide use in patients with type 2 diabetes mellitus using a propensity-score matched cohort.

17 Jul 2024

Active commuters may have lower risks of mental and physical ill health

Commuters who cycle or walk to and from work or study may have lower risks of mental and physical ill health than those who don't rely on these options, finds a large long term study published in the open access journal BMJ Public Health.

17 Jul 2024

Weill Cornell researchers define three Parkinson's subtypes with machine learning

Researchers at Weill Cornell Medicine have used machine learning to define three subtypes of Parkinson's disease based on the pace at which the disease progresses.

16 Jul 2024

CePA: Novel nanomedicine for alleviating MASH via mTOR repression

Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common chronic liver diseases, primarily caused by metabolic disorders and systemic inflammatory responses.

16 Jul 2024

E. coli genomic analysis uncovers antibiotic resistance mechanisms in dogs

Researchers studying antimicrobial-resistant E. coli – the leading cause of human death due to antimicrobial resistance worldwide – have identified a mechanism in dogs that may render multiple antibiotic classes ineffective.

16 Jul 2024

Bridging chemistry and computing to combat cancer

Vincent Zoete is developing computer tools to fight cancer. The chemist, who heads two groups at the University of Lausanne and the Swiss Institute of Bioinformatics, predicts the effects of new drugs.

16 Jul 2024

Chronic Urticaria: Addressing unmet needs, emerging therapies, and advances in personalized treatment approaches

Emerging personalized treatment approaches for chronic urticari.

16 Jul 2024

Study shows oral semaglutide matches DPP-4i in adherence and persistence for type 2 diabetes

Researchers found that adherence and persistence in T2D patients using oral semaglutide is similar to DPP-4i, but semaglutide users required fewer concurrent medications, indicating higher long-term efficacy.

16 Jul 2024

Harnessing brain proteins for enhanced diabetes and weight-loss drugs

A network of proteins found in the central nervous system could be harnessed to increase the effectiveness and reduce the side effects of popular diabetes and weight-loss drugs, according to new research from the University of Michigan.

15 Jul 2024

Cannabigerol shows promise in reducing anxiety and enhancing memory without side effects

Researchers at Washington State University found that cannabigerol (CBG) reduces anxiety and improves verbal memory without causing intoxication or impairments in healthy adults.

15 Jul 2024

Breakthrough biosensors illuminate opioid dynamics in the brain

New research from a Max Planck Florida Institute for Neuroscience researcher could transform how we understand the way opioids affect the brain.

15 Jul 2024

SH2B1 gene defends against obesity via the paraventricular hypothalamus

Obesity is a complicated condition, caused by a combination of genetics, the food environment, behavior, and other factors.

15 Jul 2024

ARPA-H funding boosts Wyss Institute's RNA therapeutic project

With the award for up to $27 million from the Advanced Research Projects Agency for Health (ARPA-H), a collaborative research project at the Wyss Institute for Biologically Inspired Engineering at Harvard University will advance a disease-agnostic novel RNA therapeutic with the potential to treat diverse diseases, and to be effectively and rapidly deployable.

15 Jul 2024

Mechanism behind propofol-induced unconsciousness revealed

There are many drugs that anesthesiologists can use to induce unconsciousness in patients. Exactly how these drugs cause the brain to lose consciousness has been a longstanding question, but MIT neuroscientists have now answered that question for one commonly used anesthesia drug.

15 Jul 2024

Innovative approaches in polymer nanoparticle synthesis for RNA therapeutics

RNA therapy with polymer nanoparticles is considered a promising approach for the treatment of various illnesses.

15 Jul 2024

New research aims to help lessen the risk of opioid misuse and overdose

New research aims to help reduce the quantity of unused prescription opioids after emergency department visits and lessen the risk of opioid misuse and overdose.

15 Jul 2024

California health care pioneer goes national, girds for partisan skirmishes

When then-Gov. Arnold Schwarzenegger called for nearly all Californians to buy health insurance or face a penalty, Anthony Wright slammed the 2007 proposal as "unwarranted, unworkable, and unwise" — one that would punish those who could least afford coverage.

15 Jul 2024

Twincretin drug Tirzepatide shows unmatched efficacy in weight loss and diabetes management

Tirzepatide, a novel twincretin drug, significantly improves weight loss and glycemic control in obese and type 2 diabetes patients, outperforming traditional treatments in clinical trials.

15 Jul 2024

Poll: Majority of Brits fear cancer diagnosis more than any other condition

Two-thirds of the public say they are very or somewhat worried about being told they have the disease – higher than for any other medical condition, including dementia and having a heart attack – according to polling released today.

14 Jul 2024