Preclinical News and Research

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Researchers develop highly specific apoptosis assay for pharmacodynamic analyses of tumor specimens

Existing microscopy-based methods of detecting apoptosis, such as TUNEL (terminal deoxynucleotidyl transferase dUTP nick-end labeling), have limited quantitative capabilities due to insufficient signal-to-noise ratios.

19 Apr 2018

High-resolution images of tumor vasculature using new technology

Thanks to a new method of analyzing ultrasound images, conventional scanners can be used for generating high-res images of blood vessels in tumors. This approach makes it easier to distinguish between different types of tumors, and it facilitates the tracking of the progress and success of chemotherapy.

18 Apr 2018

Researchers develop new method to study activity of inflammatory cells

The process that the body sets in motion in the event of inflammation is complex, but also impressive. The main role here is played by immune cells migrating from the blood into the tissue to fight the inflammation.

17 Apr 2018

Study reports promising novel approach to treat therapy resistant pediatric brain tumors

Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children.

17 Apr 2018

New faster, streamlined method for bowel cancer detection and treatment

Researchers at the South Australian Health and Medical Research Institute (SAHMRI) and the University of Adelaide have discovered a faster, more cost-effective way to determine which DNA mutations cause human bowel cancer.

17 Apr 2018

Two immune checkpoint inhibitors efficiently block leukemia development in preclinical tests

Chronic lymphocytic leukemia is a hematological malignancy that originates in the blood-forming cells of the bone marrow and spreads to other organs through the bloodstream.

17 Apr 2018

Precancerous colon polyps in Lynch syndrome patients display immune activation

Colon polyps from patients with Lynch syndrome, a hereditary condition that raises colorectal cancer risk, display immune system activation well before cancer development, according to research from The University of Texas MD Anderson Cancer Center.

16 Apr 2018

Finding ways to reverse obesity’s lingering, pro-cancer effects

Like exposure to too much sun and drinking alcohol, obesity is a risk factor for cancer. Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center are working to be a part of the solution -- they want to find ways to reverse obesity-linked biological changes in the body that are associated with cancer growth.

16 Apr 2018

Researchers find possible therapeutic strategy to block self-eating in pancreatic cancers

To get the extra energy they need to fuel their uncontrolled growth, cancer cells break down some of their own parts for fuel - a process known as autophagy, or "self-eating."

13 Apr 2018

Experimental molecular therapy to block matrix-forming protein may prevent heart failure

Scientists used an experimental targeted molecular therapy to block a matrix-forming protein in heart cells damaged by heart attack, reducing levels of scarred muscle tissue and saving mouse models from heart failure.

13 Apr 2018

KU Cancer Center to present evidence supporting anti-cancer drug at AACR 2018

The University of Kansas Cancer Center will present preclinical evidence supporting Ciclopirox Prodrug (CPX-POM), an anti-cancer agent currently in Phase I clinical trials, at the American Association for Cancer Research 2018 Annual Meeting in Chicago. Ciclopirox Prodrug was discovered by researchers at The University of Kansas Cancer Center and KU's Institute for Advancing Medical Innovation.

12 Apr 2018

Researchers review potential of targeted nanocarriers to revolutionize cancer care

A new Tel Aviv University study addresses the challenges of nanoparticle-based cancer-targeting strategies. It also suggests ways of refocusing the collaborative work of cancer researchers and clinicians to move the field forward from "the bench" to the patients.

12 Apr 2018

Dietary fats play varied roles in disease

This month's issue of the Journal of Lipid Research features studies examining how fats in the diet affect health, including whether the ketogenic diet is a reasonable cancer therapy; how the type of unsaturated fats in a mouse's chow affects inflammation; and how cells respond to nutrient signals.

12 Apr 2018

Experimental peptide drug shows promise against acute myeloid leukemia

In a study published online today in Science Translational Medicine, Albert Einstein College of Medicine researchers report that an experimental peptide drug shows promise against the often-lethal cancer acute myeloid leukemia and describe how the drug works at the molecular level.

11 Apr 2018

Research identifies link between rare gene variants and survival after blood and marrow transplant

Blood and marrow transplant, or BMT, is a lifesaving and effective treatment for many patients, but the procedure can cause serious and life-threatening complications.

10 Apr 2018

Scientists find new molecular target to treat idiopathic pulmonary fibrosis

Scientists searching for a therapy to stop the deadly and mostly untreatable lung disease, idiopathic pulmonary fibrosis (IPF), found a new molecular target that slows or stops the illness in preclinical laboratory tests.

10 Apr 2018

Researchers suggest alternative therapy for heart attack patients with beta blocker intolerance

Beta blockers have become a prescription drug staple for recovering heart attack patients. However, these blood pressure-reducing medications cannot be tolerated by many patients who are at higher risk for developing cardiovascular disease, including those with chronic obstructive pulmonary disease and asthma, the elderly, and diabetics.

10 Apr 2018

Houston Methodist-led research focuses on rare, inherited neurodegenerative disorder

A rare, inherited neurodegenerative disorder will soon be the focus of an international clinical research effort led by Houston Methodist and funded by the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health.

10 Apr 2018

Nosopharm and UIC reveal pharmacology of new class of antibiotics to combat drug resistance

Nosopharm, a company dedicated to the research and development of new anti-infective drugs, and the University of Illinois at Chicago today announce the publication of a study in Molecular Cell on the mechanism of action of odilorhabdins, a new class of antibiotics to combat antibiotic resistance.

9 Apr 2018

MILabs reports continuous growth in sales of preclinical imaging systems

MILabs B.V. reported that for the third year in a row, the rapidly-innovating molecular imaging company has continued on its trajectory of strong preclinical imaging systems sales with another year-to-year rise close to 50%.

9 Apr 2018

Preclinical News and Research

Researchers develop highly specific apoptosis assay for pharmacodynamic analyses of tumor specimens

High-resolution images of tumor vasculature using new technology

Researchers develop new method to study activity of inflammatory cells

Study reports promising novel approach to treat therapy resistant pediatric brain tumors

New faster, streamlined method for bowel cancer detection and treatment

Two immune checkpoint inhibitors efficiently block leukemia development in preclinical tests

Precancerous colon polyps in Lynch syndrome patients display immune activation

Finding ways to reverse obesity’s lingering, pro-cancer effects

Researchers find possible therapeutic strategy to block self-eating in pancreatic cancers

Experimental molecular therapy to block matrix-forming protein may prevent heart failure

KU Cancer Center to present evidence supporting anti-cancer drug at AACR 2018

Researchers review potential of targeted nanocarriers to revolutionize cancer care

Dietary fats play varied roles in disease

Experimental peptide drug shows promise against acute myeloid leukemia

Research identifies link between rare gene variants and survival after blood and marrow transplant

Scientists find new molecular target to treat idiopathic pulmonary fibrosis

Researchers suggest alternative therapy for heart attack patients with beta blocker intolerance

Houston Methodist-led research focuses on rare, inherited neurodegenerative disorder

Nosopharm and UIC reveal pharmacology of new class of antibiotics to combat drug resistance

MILabs reports continuous growth in sales of preclinical imaging systems

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