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Evidence grows for pirtobrutinib as a safer and effective alternative for CLL and SLL

Pirtobrutinib, a non-covalent Bruton tyrosine kinase (BTK) inhibitor, met the primary endpoint for non-inferiority in terms of overall response rate in the first head-to-head comparison with ibrutinib, a covalent BTK inhibitor.

7 Dec 2025

Aza-ven shows superior outcomes compared to induction chemotherapy in AML patients

In a new trial, patients newly diagnosed with acute myeloid leukemia (AML) fared significantly better with a combined regimen of azacitidine and venetoclax compared with conventional induction chemotherapy.

7 Dec 2025

Walking speed before surgery predicts who thrives after hip replacement

This study shows that preoperative gait speed is a strong predictor of patient-reported pain relief, function, and joint awareness after total hip arthroplasty for osteoarthritis. A walking speed of at least 1.0 m/s before surgery independently predicts excellent postoperative outcomes.

7 Dec 2025

Fixed-duration therapy works as effectively as continuous treatment for chronic lymphocytic leukemia

According to a new trial, patients with chronic lymphocytic leukemia (CLL) show comparable outcomes whether they receive a single-agent treatment indefinitely or a combination treatment for a fixed period of time.

7 Dec 2025

Chemotherapy-based conditioning matches outcomes of total body irradiation for MRD-negative B-ALL

In a new trial, patients with B-acute lymphoblastic leukemia (B-ALL) who had no evidence of remaining cancer cells after prior treatment, experienced comparable outcomes whether they received chemotherapy-based conditioning or total body irradiation (TBI), the standard conditioning regimen used before hematopoietic cell transplantation.

7 Dec 2025

Black patients with AML experience earlier onset and poorer outcomes

Compared with white patients, Black patients with acute myeloid leukemia (AML) were on average more than five years younger at diagnosis, more than 30% more likely to die of their disease, and more than 20% more likely to die of any cause, according to an analysis of data conducted over a 34-year period and supported by the National Cancer Institute (NCI) is a component of the U.S. National Institutes of Health.

7 Dec 2025

Challenges and opportunities in delivering gene therapies for sickle cell disease and beta thalassemia

The first study assessing the real-world commercial roll-out of gene therapies for sickle cell disease and beta thalassemia offers lessons learned to inform best practices as manufacturers and medical centers prepare to meet growing demand for gene therapies in the coming years.

7 Dec 2025

New evidence shows hematopoietic cell transplantation offers durable relief for sickle cell disease

Patients who underwent hematopoietic cell transplantation for sickle cell disease saw high rates of survival without disease symptoms and low rates of severe side effects or complications years after their procedure, according to a new study.

7 Dec 2025

Exa-cel shows complete success in early pediatric trials for sickle cell disease and beta-thalassemia

Preliminary results from two trials of the gene therapy exagamglogene autotemcel (exa-cel) suggest the therapy offers an effective cure for beta-thalassemia and sickle cell disease in children younger than 12.

6 Dec 2025

$New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer$

New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer

A new targeted alpha therapy is showing promise for patients whose thyroid cancer no longer responds to radioactive iodine, the standard beta-emitting treatment. In a first-in-human study, investigators found that a single dose of the alpha-emitting radionuclide 211At (astatine) was both well-tolerated and effective, achieving disease control without molecularly targeted drugs.

5 Dec 2025

New rapid test distinguishes real HIV infections from vaccine-related false positives

Since the human immunodeficiency virus (HIV) was identified in 1983, roughly 91.4 million people around the world have contracted the virus and an additional 44.1 million have died from related causes.

3 Dec 2025

Study finds link between Pg-induced periapical disease and systemic metabolic dysfunction

New study examines the oral pathogen Porphyromonas gingivalis (Pg) and suggests its influence may extend beyond dental tissues.

3 Dec 2025

Breast cancer reshapes lymphatic vessels to support its spread

Breast cancer is able to modify the lymphatic vessels through which it travels to the draining lymph nodes. From there, it can then spread to other parts of the body.

3 Dec 2025

Stem cells reshape in response to electrical signals, study reveals

Scientists in Melbourne have discovered how tiny electrical pulses can steer stem cells as they grow, opening the door to new improved ways of creating new tissues, organs, nerves and bones.

3 Dec 2025

Experts call for comprehensive measures to reduce injury risks for female athletes

reating a safe, gender-specific, supportive environment-one that is free of body shaming and idealised female forms, for example-is key to minimising female athletes' future risks of injury and protecting their health, emphasizes the Female/woman/girl Athlete Injury pRevention (FAIR) Consensus Statement-the first of its kind-published online in the British Journal of Sports Medicine.

2 Dec 2025

Bone News and Research

Evidence grows for pirtobrutinib as a safer and effective alternative for CLL and SLL

Aza-ven shows superior outcomes compared to induction chemotherapy in AML patients

Walking speed before surgery predicts who thrives after hip replacement

Fixed-duration therapy works as effectively as continuous treatment for chronic lymphocytic leukemia

Chemotherapy-based conditioning matches outcomes of total body irradiation for MRD-negative B-ALL

Black patients with AML experience earlier onset and poorer outcomes

Challenges and opportunities in delivering gene therapies for sickle cell disease and beta thalassemia

New evidence shows hematopoietic cell transplantation offers durable relief for sickle cell disease

Exa-cel shows complete success in early pediatric trials for sickle cell disease and beta-thalassemia

New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer

New rapid test distinguishes real HIV infections from vaccine-related false positives

Study finds link between Pg-induced periapical disease and systemic metabolic dysfunction

Breast cancer reshapes lymphatic vessels to support its spread

Stem cells reshape in response to electrical signals, study reveals

Experts call for comprehensive measures to reduce injury risks for female athletes

Walking speed before hip replacement predicts long-term recovery success

A new generation of AML treatments brings hope for better survival

Study explores the impact of total knee replacement surgery cancellations across UK hospitals

Study finds surprising differences in knee injuries between men and women

Semaglutide helps older adults lose weight without immediate bone loss

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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