Cytotoxicity News and Research

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Study reveals how molecular mechanisms regulate lysosomal exocytosis by phagocytes

Lysosomes are filled with more than 50 different hydrolytic enzymes, which are capable of digesting most cellular components.

23 Dec 2018

Small populations of normal T cells could modify disease severity in patients with XLP1

Human SH2D1A mutations resulting in X-linked lymphoproliferative syndrome type 1 are associated with a unique susceptibility to the Epstein-Barr virus, which may lead to fatal infectious mononucleosis.

9 Nov 2018

Study reveals unknown mechanism that protects tumor cells from NK cell-mediated cytotoxicity

Cancer cells have evolved multiple escape strategies to circumvent the body's immune defenses such as the attack by Natural Killer (NK) cells which normally swiftly kill abnormal cells by releasing cytotoxic products.

24 Oct 2018

Using Galleria mellonella to assess acute toxicity of chemicals

TruLarv is considered a non-animal technology in the context of UK animal use regulations where procedures on this species are not regulated.

17 Oct 2018

Logos Biosystems Introduces the New CELENA X High Content Imaging System

Logos Biosystems has released the all-new CELENA® X integrated High Content Imaging System, providing the complete solution for rapid high content image acquisition and quantitative analysis.

From Logos Biosystems 20 Sep 2018

PolyU researchers design new self-fitting scaffold to induce bone regeneration

Researchers from The Hong Kong Polytechnic University have designed and fabricated a high performing self-fitting bone scaffold by combining a shape memory foam and hydroxyapatite (the principal mineral component of bone tissue).

17 Aug 2018

Researchers develop near-infrared fluorophores-based PDT to cure cancer with less side effects

A KAIST research team developed near-infrared fluorophores-based photodynamic therapy that reduced the downside of existing PDTs.

16 Jul 2018

Chemist begins new project to develop carbohydrate mimics to assist cancer therapies

Dr. Robert Britton firmly believes every molecule is important. This chemist doesn't want any molecule sitting unused on a laboratory shelf or in a fridge.

18 May 2018

ONC201 disrupts mitochondrial function and kills breast cancer cells, reveals study

TRAIL, a member of the TNF family of ligands, causes caspase-dependent apoptosis through activation of its receptors, death receptor 4 and DR5.

9 May 2018

Researchers analyze toxicity, other health risks of electronic tobacco heating system

The project was implemented in accordance with the request of the Government of Russian Federation on the evaluation of non-medicinal nicotine products. The inter-agency research group was based at the Semashko National Scientific Research Institute of Public Health.

7 May 2018

New optogenetic tools show promise in treating cardiovascular, neuropsychiatric disorders

You've heard of "nature versus nurture," and philosophers argue about which is more important. But how does this work on the cellular level?

27 Apr 2018

Can GAC Be Used to Control Priority Unregulated DBPs in Drinking Water?

In this interview, Prof. Susan Richardson discusses the use of GAC to control disinfection by-products.

From Pittcon 23 Apr 2018

New fluorescent probe identifies cancer stem cells

Cells with stem-cell characteristics appear to be especially important in the formation and metastasis of tumors. Scientists have now developed a universal fluorescent probe for these "cancer stem cells". As reported in the journal Angewandte Chemie, this dye also selectively kills off the cells.

4 Apr 2018

Topical solution may be less cytotoxic than cryosurgery for patients with seborrheic keratosis

Seborrheic keratosis is the most common noncancerous skin growth in adults seen by doctors in everyday practice.

29 Mar 2018

Researchers determine cause of difficult-to-control mitochondrial diseases

A Japanese research group has discovered that taurine is conjugated with mitochondrial transfer RNAs (tRNAs), small RNAs that decode genetic information, and that taurine deficiency in tRNA dramatically reduces both mitochondrial protein translation and impairs mitochondrial membrane integrity.

7 Mar 2018

Scientists develop water-soluble warped nanographene for bioimaging

An international team of scientists has developed a water-soluble "warped nanographene", a flexible molecule that is biocompatible and shows promise for fluorescent cell imaging.

19 Feb 2018

Scientists develop fluorescent probe to identify cancer stem cells

Cells with stem-cell characteristics appear to be especially important in the formation and metastasis of tumors. Scientists have now developed a universal fluorescent probe for these “cancer stem cells”. As reported in the journal Angewandte Chemie, this dye also selectively kills off the cells.

19 Feb 2018

Brazilian researchers identify genes linked to melanoma progression

When researchers at the University of São Paulo in Brazil treated human melanoma cell lines with a synthetic compound similar to curcumin, one of the pigments that give turmeric its orange color, they identified genes with altered expression in potentially invasive tumors and malignant cells resistant to chemotherapy.

6 Dec 2017

Penn study: New dental material kills bacteria and resists biofilm growth

Dentists rely on composite materials to perform restorative procedures, such as filling cavities. Yet these materials, like tooth enamel, can be vulnerable to the growth of plaque, the sticky biofilm that leads to tooth decay.

5 Dec 2017

Scientists develop unique CRISPR-based method for more precise, systematic gene tagging

The genome editing tool known as CRISPR/Cas9 has opened many doors for biomedical research by allowing scientists to precisely edit DNA sequences and alter function. The technology offers hope for correcting genetic defects and preventing disease.

24 Oct 2017