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Simple blood tests for telomeric protein could provide a valuable screen for certain cancers

Once thought incapable of encoding proteins due to their simple monotonous repetitions of DNA, tiny telomeres at the tips of our chromosomes seem to hold a potent biological function that's potentially relevant to our understanding of cancer and aging.

21 Feb 2023

HKU research advances understanding of the fundamental biological processes of gene regulation

A research team from the University of Hong Kong led by Professor Xiang David Li from the Department of Chemistry in collaboration with Dr Yuanliang Zhai from the HKU School of Biological Sciences and Dr Jason Wing Hon Wong and Dr Xiucong Bao from the HKU School of Biomedical Sciences recently made a key breakthrough in understanding how genetic information encoded in our DNA is 'read' and why errors in 'reading' such information can often lead to developmental defects or cancers.

20 Feb 2023

Scientists identify miRNAs associated with type 2 diabetes in humans

MicroRNA (miRNA) molecules in pancreatic islets have been thought to play important roles in type 2 diabetes, but until now scientists have not confidently identified which miRNAs are associated with the disease in humans.

10 Feb 2023

New compound limits the replication of influenza viruses

Viruses use the molecular repertoire of the host cell to replicate. Researchers from the Cluster of Excellence ImmunoSensation2 at the University of Bonn, together with Japanese researchers, want to exploit this for the treatment of influenza.

9 Feb 2023

Increase in 'twisting' of retinal arteries could cause high blood pressure and heart disease

Research led by scientists at St George's, University of London has discovered 119 areas in the genome that help to determine the size and shape of blood vessels at the back of the eye, and that an increase in 'twisting' of the arteries could cause high blood pressure and heart disease.

9 Feb 2023

A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

Researchers developed a WGS method that read four canonical DNA bases, viz., adenine (A), cytosine (C), guanine (G), and thymine (T) plus 5mC and 5hmC, epigenetic variants of unmodified C to yield an accurate six-letter digital readout in a single workflow.

9 Feb 2023

New strategies to beat rare tumors of the adrenal gland

Only one in 100,000 people suffer from a pheochromocytoma, a tumor of the adrenal gland. If the tumor has already metastasized, a radioactive compound can be used to detect malignant cells that have spread to other parts of the body, and to irradiate them from the inside.

9 Feb 2023

Researchers identify new mechanism that causes hereditary diseases

Researchers from Charité – Universitätsmedizin Berlin, the Max Planck Institute for Molecular Genetics (MPIMG), and the University Hospital Schleswig-Holstein (UKSH) have investigated in detail how BPTA syndrome, an extremely rare hereditary condition, arises.

9 Feb 2023

Researchers discover a new hexameric structure of the RepB protein and how it binds to DNA

In all living organisms, DNA replication is essential to ensure the genetic fidelity of the next generation. However, bacteria can also transfer genetic information horizontally to other bacteria.

3 Feb 2023

Novel tool uses AI to predict the efficacy of genome-editing repair options

Researchers at the University of Zurich have developed a new tool that uses artificial intelligence to predict the efficacy of various genome-editing repair options.

2 Feb 2023

Effectiveness of exome and genome sequencing to detect undiagnosed syndromes

Scientists review existing literature to evaluate the advancements in genomic and exome sequencing for the accurate detection of undiagnosed syndromes.

1 Feb 2023

Cancer immunotherapy does not interfere with COVID-19 immunity in vaccinated patients, study shows

Research findings published in Frontiers in Immunology show that cancer immunotherapy does not interfere with COVID-19 immunity in previously vaccinated patients.

31 Jan 2023

Metastatic Melanoma: key protein identified that aids the spread of skin cancer

In this interview, News-Medical spoke to Dr. Jeremy Carlton and Professor Victoria Sanz-Moreno about their latest research into the spread of skin cancer.

20 Jan 2023

The loss of epigenetic information accelerates the aging process

A new study in the journal Cell aimed to determine whether epigenetic changes are a cause of mammalian aging.

15 Jan 2023

Researchers unveil new methods for DNA mosaic recognition

As humans, we each have trillions of cells. And each cell has a nucleus with individual genetic information –DNA – that can mutate to create an abnormality.

13 Jan 2023

Unique mass spectrometry-based approach to study specific changes in DNA after replication

A new method to study specific changes in DNA after replication has been published as a technical report in Nature Cell Biology.

12 Jan 2023

Researchers discover a protein that makes melanoma more aggressive

Research led by Queen Mary University of London, King's College London and the Francis Crick Institute has identified a protein that makes melanoma, the most serious type of skin cancer, more aggressive by giving cancer cells the ability to change the shape of their nucleus – a characteristic which allows the cells to migrate and spread around the body.

9 Jan 2023

Genetic Information News and Research

Simple blood tests for telomeric protein could provide a valuable screen for certain cancers

HKU research advances understanding of the fundamental biological processes of gene regulation

Scientists identify miRNAs associated with type 2 diabetes in humans

New compound limits the replication of influenza viruses

Increase in 'twisting' of retinal arteries could cause high blood pressure and heart disease

A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

New strategies to beat rare tumors of the adrenal gland

Researchers identify new mechanism that causes hereditary diseases

Researchers discover a new hexameric structure of the RepB protein and how it binds to DNA

Novel tool uses AI to predict the efficacy of genome-editing repair options

Effectiveness of exome and genome sequencing to detect undiagnosed syndromes

Cancer immunotherapy does not interfere with COVID-19 immunity in vaccinated patients, study shows

Metastatic Melanoma: key protein identified that aids the spread of skin cancer

The loss of epigenetic information accelerates the aging process

Researchers unveil new methods for DNA mosaic recognition

Unique mass spectrometry-based approach to study specific changes in DNA after replication

Researchers discover a protein that makes melanoma more aggressive

Scientists discover nearly 100,000 new types of viruses

Researchers design 3D structures made of DNA

PTSD, TBI, and a genetic variant show strong links with Alzheimer's Disease and related dementias

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