Preclinical News and Research

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Novel grape-derived compounds could be developed as therapeutic agents for treatment of depression

In a study to be published online February 2 in Nature Communications, scientists from the Icahn School of Medicine at Mount Sinai describe an extensive analysis of novel grape-derived compounds, dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc),which might be developed as therapeutic agents for the treatment of depression.

2 Feb 2018

MR Solutions’ latest spectrometer offers advanced functionality for clinical MRI manufacturers

MR Solutions’ latest EVO2+ spectrometer now offers the most advanced levels of functionality and user control for constructors of clinical MRI scanners.

From MR Solutions 2 Feb 2018

Study unravels developmental splicing program that promotes neuronal maturation

Neurons, or nerve cells, in the brain communicate with each other by transmitting electric signals, or firing action potentials, through long processes named axons (which send out signals) and dendrites (which receive signals).

1 Feb 2018

Neuroscientists identify 'anxiety cells' in the brain's hippocampus

Do your palms sweat when you walk down a poorly lit street at night? That feeling may be traced to the firing of newly identified "anxiety" cells deep inside your brain, according to new research from neuroscientists at Columbia University Irving Medical Center and the University of California, San Francisco.

31 Jan 2018

Scientists discover how gene mutation affects T cell function to promote immune disorders

Scientists discovered how a gene mutation affects T cell function to promote immune disorders and then tested a treatment based on the discovery - successfully fixing donated immune cells from a 16-year-old boy with an abnormally low level of white blood cells called lymphopenia.

30 Jan 2018

Interrupted sleep could be an early sign of Alzheimer’s disease, finds new study

Disrupted circadian rhythm patterns could be an early sign of Alzheimer's disease, finds new study.

30 Jan 2018

Psychiatric drugs do not appear to be overprescribed for children, study reveals

A new study at Columbia University Irving Medical Center challenges the popular notion that psychiatric medications are overprescribed in children and adolescents in the U.S.

30 Jan 2018

Circadian rhythm disruptions occur much earlier in people at risk of Alzheimer's

People with Alzheimer's disease are known to have disturbances in their internal body clocks that affect the sleep/wake cycle and may increase risk of developing the disorder.

29 Jan 2018

Researchers win $6.5 million NIH grant to personalize diagnosis and treatment of psoriasis

An experienced interdisciplinary team of psoriasis and computational researchers from Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center has received a $6.5M, 5-year grant from the National Institute of Arthritis, Musculoskeletal and Skin Diseases.

29 Jan 2018

Study reveals existence of previously unknown immune defense mechanisms in bacteria

Until a decade ago, scientists were not aware that bacteria had complex immune systems – ones that could keep up with the pace of evolution in viruses called phages that infect bacteria.

27 Jan 2018

Researchers use biomimetic engineering approach to develop vascular grafts

When a patient with heart disease is in need of a vascular graft but doesn't have any viable veins or arteries in his or her own body, surgeons can rely on synthetic, tissue-engineering grafts.

24 Jan 2018

Researchers block common siren call of glioblastoma and metastatic breast cancer

Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

23 Jan 2018

Study identifies genes involved in latent asymptomatic state of breast cancer metastases

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumor) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body).

23 Jan 2018

New precision medicine approach for metastatic pancreatic cancer

A three-year grant has been awarded to fund a phase 1b clinical trial of a precision medicine approach to treating metastatic pancreatic cancer.

18 Jan 2018

Study to test new precision medicine approach for metastatic pancreatic cancer

The Lustgarten Foundation has awarded Columbia University's Herbert Irving Comprehensive Cancer Center a three-year grant, as part of its Translational Clinical Program, to test a new precision medicine approach to the treatment of metastatic pancreatic cancer.

18 Jan 2018

Research: Men who lack HSD17B4 gene may be more susceptible to treatment-resistant prostate cancer

Cleveland Clinic researchers have confirmed for the first time a mechanistic link between the gene HSD17B4 and deadly, treatment-resistant prostate cancer.

17 Jan 2018

Researchers identify new anti-inflammatory drug target

A new study suggests that parmodulins may provide anti-inflammatory and anti-thrombotic protection to endothelial cells, without interfering with clotting.

16 Jan 2018

Prostate cancer’s gene-determined ‘immune landscape’ dictates tumor progression

The field of immunotherapy - the harnessing of patients' own immune systems to fend off cancer - is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.

12 Jan 2018

Worsening of anxiety symptoms may be early indicator of Alzheimer's disease

A new study suggests an association between elevated amyloid beta levels and the worsening of anxiety symptoms. The findings support the hypothesis that neuropsychiatric symptoms could represent the early manifestation of Alzheimer's disease in older adults.

12 Jan 2018

New drug candidates may offer breakthrough in treatment of COPD

The study was a cooperative effort between the team headed by assistant professor Dr Jürgen Knobloch from the Medical Clinic III for Pneumology, Sleep and Respiratory Medicine at the Bergmannsheil University Hospital in Bochum, Germany, and Prof Dr Andrea Koch, member of the German Center for Lung Research, previously in Bochum, now at the Medical Clinic V for Pneumology at the LMU University Hospital in Munich, as well as a team from the company RespiVert Ltd, a subsidiary of Janssen Biotech Inc., and Prof Dr Erich Stoelben from the Lung Clinic in Köln-Merheim.

12 Jan 2018

Preclinical News and Research

Novel grape-derived compounds could be developed as therapeutic agents for treatment of depression

MR Solutions’ latest spectrometer offers advanced functionality for clinical MRI manufacturers

Study unravels developmental splicing program that promotes neuronal maturation

Neuroscientists identify 'anxiety cells' in the brain's hippocampus

Scientists discover how gene mutation affects T cell function to promote immune disorders

Interrupted sleep could be an early sign of Alzheimer’s disease, finds new study

Psychiatric drugs do not appear to be overprescribed for children, study reveals

Circadian rhythm disruptions occur much earlier in people at risk of Alzheimer's

Researchers win $6.5 million NIH grant to personalize diagnosis and treatment of psoriasis

Study reveals existence of previously unknown immune defense mechanisms in bacteria

Researchers use biomimetic engineering approach to develop vascular grafts

Researchers block common siren call of glioblastoma and metastatic breast cancer

Study identifies genes involved in latent asymptomatic state of breast cancer metastases

New precision medicine approach for metastatic pancreatic cancer

Study to test new precision medicine approach for metastatic pancreatic cancer

Research: Men who lack HSD17B4 gene may be more susceptible to treatment-resistant prostate cancer

Researchers identify new anti-inflammatory drug target

Prostate cancer’s gene-determined ‘immune landscape’ dictates tumor progression

Worsening of anxiety symptoms may be early indicator of Alzheimer's disease

New drug candidates may offer breakthrough in treatment of COPD

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