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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Novel class of sulfonamides to block malaria transmission

Malaria is a devastating disease, with 247 million cases and 619,000 deaths reported in 2021 alone. Malaria causes fever and a flu-like illness that occurs when people are infected with the parasite Plasmodium falciparum, which is spread by mosquitoes.

30 Jan 2023

Serotonin can potentially accelerate degenerative mitral regurgitation, study says

Serotonin can impact the mitral valve of the heart and potentially accelerate a cardiac condition known as degenerative mitral regurgitation, according to a new study led by researchers at Columbia University's Department of Surgery in collaboration with the Pediatric Heart Valve Center at Children's Hospital of Philadelphia, the University of Pennsylvania, and the Valley Hospital Heart Institute.

29 Jan 2023

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

27 Jan 2023

Activated neutrophils can become potent cancer fighters

Elevated levels of immune cells, called neutrophils, in tumors have been associated with poor outcomes in people with cancer.

27 Jan 2023

Protein adduction and p53 tumor suppressor inhibition

Researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition.

27 Jan 2023

Research offers hope for patients affected by rare, hereditary metabolic disease

Methylmalonic aciduria (MMA) is a metabolic disorder that affects approximately one in 90,000 newborns; both parents must carry a genetic predisposition to the disease.

26 Jan 2023

Novel papillomaviruses identified in Malayan and Chinese pangolins

Researchers identify two novel lineages of papillomaviruses by mining the genome data of Chinese and Malayan pangolins.

26 Jan 2023

AI tool promises to accelerate the development of gene therapies on a large scale

An artificial intelligence (AI) program may enable the first simple production of customizable proteins called zinc fingers to treat diseases by turning genes on and off.

26 Jan 2023

Pancreatic cancer study reveals the cause of tumor cell resistance to immunotherapy

A new study that analyzed the tumor microenvironment of pancreatic cancer revealed the cause of tumor cell resistance to immunotherapy and resulted in new treatment strategies.

26 Jan 2023

Scientists receive $2.9 million NIH grant to better understand the genetics of IBD in Hispanics

After studying the genetic sequences of more than 100,000 people, researchers around the country have started to uncover the root causes of inflammatory bowel disease (IBD), Crohn's disease, and ulcerative colitis.

26 Jan 2023

Study identifies the DNA roots of resistance to targeted cancer therapy

A new clinical and preclinical study from UCLA Jonsson Comprehensive Cancer Center identifies the DNA roots of resistance to targeted cancer therapy, providing a possible strategy to address a vexing issue in cancer therapeutics.

26 Jan 2023

Study shows improved host health by modulating intestinal microbiota

Researchers presented intestinal microbiota modulation as a probable therapeutic option for diseases such as Crohn’s disease (CD).

26 Jan 2023

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital used a next-generation protein degradation technology to study CTCF.

26 Jan 2023

Scientists illuminate how blood cancer treatments can lead to therapy-related myeloid neoplasms

Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have illuminated how treatments for multiple myeloma and other aggressive blood cancers can lead to future malignancies, called therapy-related myeloid neoplasms (tMNs).

25 Jan 2023

Scientists reveal how genetic changes lead to differences in the size of cancer cells

Cancer cells can shrink or super-size themselves to survive drug treatment or other challenges within their environment, researchers have discovered.

25 Jan 2023

New method analyzes long-range interactions in the interactome

Researchers at the Josep Carreras Leukaemia Research Institute have developed a method to analyze long-range interactions in the DNA -the interactome- from a very low amount of starting material.

25 Jan 2023

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.

25 Jan 2023

An evaluation of pediatric Mpox specimens

In a recent study posted to the medRxiv* preprint server, researchers in the United States performed the clinical evaluation of pediatric monkeypox (mpox) specimens.

25 Jan 2023

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome - a cell's complete set of DNA - is most vulnerable while it is being duplicated before a cell divides. Cancer cells constantly are dividing, so their genomes are constantly in jeopardy.

24 Jan 2023

Mosaic RBD nanoparticles offer 100% protection against SARS-CoV-2 in animal model

A recent PNAS journal study has sought to address the above-stated drawback and developed a new strategy that involves a self-assembling scaffold of proliferating cell nuclear antigen (PCNA). This technique can develop nanoparticles containing evenly incorporated heterotypic antigens.

24 Jan 2023

DNA News and Research

Further Reading

Novel class of sulfonamides to block malaria transmission

Serotonin can potentially accelerate degenerative mitral regurgitation, study says

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

Activated neutrophils can become potent cancer fighters

Protein adduction and p53 tumor suppressor inhibition

Research offers hope for patients affected by rare, hereditary metabolic disease

Novel papillomaviruses identified in Malayan and Chinese pangolins

AI tool promises to accelerate the development of gene therapies on a large scale

Pancreatic cancer study reveals the cause of tumor cell resistance to immunotherapy

Scientists receive $2.9 million NIH grant to better understand the genetics of IBD in Hispanics

Study identifies the DNA roots of resistance to targeted cancer therapy

Study shows improved host health by modulating intestinal microbiota

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

Scientists illuminate how blood cancer treatments can lead to therapy-related myeloid neoplasms

Scientists reveal how genetic changes lead to differences in the size of cancer cells

New method analyzes long-range interactions in the interactome

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

An evaluation of pediatric Mpox specimens

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Mosaic RBD nanoparticles offer 100% protection against SARS-CoV-2 in animal model

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