Immune System News and Research

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Study finds dimethyl fumarate was not associated with an improvement in clinical outcomes in adults hospitalized with COVID-19

Researchers evaluated the efficacy of the anti-inflammatory drug dimethyl fumarate in treating COVID-19 as part of an early phase, randomized, controlled assessment trial in the UK.

28 Sep 2022

One-time test predicts which hospitalized COVID-19 patients are likely to worsen, study finds

A one-time test could predict which people hospitalized with COVID-19 are likely to worsen significantly during their stay, even if they were admitted with relatively mild symptoms, according to a study of more than 2,500 people headed by researchers at Stanford Medicine.

27 Sep 2022

Food, vaccines, bacteria, and viruses may all prime our immune system to attack SARS-CoV-2

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, primarily causes mild to moderate upper-respiratory tract illness. However, some individuals with COVID-19 develop severe infections and require hospital admission.

27 Sep 2022

Giving immunotherapy before targeted therapy improves survival in patients with advanced melanoma

A clinical trial led by clinicians at Georgetown Lombardi Comprehensive Cancer Center showed a remarkable 20 percent advantage in the two-year overall survival rate for people with advanced melanoma who first received immunotherapy (72 percent survival rate) versus those who initially got targeted therapies (52 percent survival rate).

27 Sep 2022

How the gut microbiome could affect COVID-19 severity

Researchers review the potential role of the gut microbiome in determining severe COVID-19.

27 Sep 2022

Spectroscopy reveals a high abundance of microplastics in human placenta

Scientists have used a spectroscopy technique to identify and characterize microplastics in the human placenta. The study published in the journal Science of The Total Environment provides a detailed overview of the size, shape, and nature of microplastics found in the placenta.

27 Sep 2022

High-tech lab in Nigeria could be a game changer in tackling emerging and re-emerging diseases

Nigeria's Oligo synthesizer laboratory, the first in West Africa, could be a game changer in tackling emerging and re-emerging diseases in the region if harnessed to its full potential, laboratory scientists have said.

27 Sep 2022

Leducq Foundation awards $15 million to advance the understanding of atherosclerosis

The Leducq Foundation has awarded $15 million to researchers at UVA Health and their collaborators to advance our understanding of atherosclerosis, or hardening of the arteries, and find better ways to treat it. Diseases linked to atherosclerosis are the leading cause of death in the United States.

27 Sep 2022

Some pre-existing conditions matter a lot more when assessing COVID-19 outcomes

A new paper in Biology Methods & Protocols, published by Oxford University Press, indicates that some pre-existing conditions - including degenerative neurological diseases, dementia, and severe disabilities - matter a lot more than once thought when assessing who is at risk for death due to COVID-19.

27 Sep 2022

Transplantation tolerance associated with conventional T cells’ susceptibility to Treg suppression

Patients who receive organ transplants must take powerful medications to prevent the immune system from rejecting the organ.

27 Sep 2022

Researchers uncover a new way the immune system detects coronavirus infection

In a recent study posted to bioRxiv*, researchers in the United States demonstrated that the main protease (Mpro) of coronaviruses (CoVs) activates host inflammasome responses.

27 Sep 2022

Consumption of highly refined fiber may increase liver cancer risk in some people

Many people commonly consume fiber-enriched foods to promote weight loss and prevent chronic diseases such as diabetes and cancer.

26 Sep 2022

Study finds remdesivir-resistant version of COVID-19 in renal transplant recipients

Recent studies have shown that patients with weakened immune systems—which enables the virus that causes COVID-19 to remain longer in the body, copy itself, and continually change—may enable the development of new, slightly different versions of the virus (variants).

26 Sep 2022

Scientists identify immune targets for chemotherapy-resistant breast cancers

Scientists have identified immune cell types that could be targeted to develop specific immunotherapies in chemotherapy-resistant breast cancers.

26 Sep 2022

A good night's sleep promotes immunity

In a recent study published in the Journal of Experimental Medicine, researchers in the United States used mice models to understand how sleep fragmentation affects immunological responses and the epigenetic modifications of hematopoietic stem and progenitor cells (HSPCs). They also conducted a sleep restriction trial in humans to determine HPSC programming and hematopoiesis.

25 Sep 2022

Novel PTP1B inhibitor drug candidate can prevent lethal lung inflammation in mice

Neutrophils, the most abundant type of white blood cell, are the body's first line of defense against infection. Foreign pathogens can stress the body and activate neutrophils.

23 Sep 2022

Studies explore how differences in skin composition may lead to dermatological conditions

Why are certain body parts more prone to skin diseases than others? Two new UC Davis Health studies explored how differences in skin composition may lead to dermatological conditions, such as psoriasis and atopic dermatitis.

23 Sep 2022

Research reveals how carp virus uses a protein domain to inhibit host cell’s defense mechanisms

The team of Prof. Alain Vanderplasschen, virologist and immunologist at the University of Liège, has published an article in the journal Nucleic Acids Research, reporting ten years of research on how a carp virus has been using a protein domain called Zalpha (Zα) to inhibit the defense mechanisms of the host cell.

23 Sep 2022

Review: Cold water swimming may cut 'bad' body fat in men and reduce the risk of diabetes

Taking a dip in cold water may cut 'bad' body fat in men and reduce the risk of disorders such as diabetes, suggests a major scientific review published in the peer-reviewed International Journal of Circumpolar Health.

23 Sep 2022

UVA's new discovery could help ramp up production of blood-clotting platelets

A new discovery from the University of Virginia School of Medicine could let doctors ramp up production of blood-clotting platelets on demand, a timely finding following the Red Cross' declaration earlier this year of a national blood "crisis."

23 Sep 2022

Immune System News and Research

Study finds dimethyl fumarate was not associated with an improvement in clinical outcomes in adults hospitalized with COVID-19

One-time test predicts which hospitalized COVID-19 patients are likely to worsen, study finds

Food, vaccines, bacteria, and viruses may all prime our immune system to attack SARS-CoV-2

Giving immunotherapy before targeted therapy improves survival in patients with advanced melanoma

How the gut microbiome could affect COVID-19 severity

Spectroscopy reveals a high abundance of microplastics in human placenta

High-tech lab in Nigeria could be a game changer in tackling emerging and re-emerging diseases

Leducq Foundation awards $15 million to advance the understanding of atherosclerosis

Some pre-existing conditions matter a lot more when assessing COVID-19 outcomes

Transplantation tolerance associated with conventional T cells’ susceptibility to Treg suppression

Researchers uncover a new way the immune system detects coronavirus infection

Consumption of highly refined fiber may increase liver cancer risk in some people

Study finds remdesivir-resistant version of COVID-19 in renal transplant recipients

Scientists identify immune targets for chemotherapy-resistant breast cancers

A good night's sleep promotes immunity

Novel PTP1B inhibitor drug candidate can prevent lethal lung inflammation in mice

Studies explore how differences in skin composition may lead to dermatological conditions

Research reveals how carp virus uses a protein domain to inhibit host cell’s defense mechanisms

Review: Cold water swimming may cut 'bad' body fat in men and reduce the risk of diabetes

UVA's new discovery could help ramp up production of blood-clotting platelets

Understanding the DNA Damage Response in Innate Immunity eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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